Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
19459177
TITLE
Education, occupation and retirement age effects on the age of onset of Alzheimer's disease.
ABSTRACT
OBJECTIVE NlmCategory: OBJECTIVE
To determine the effects of early life education, mid life employment and later life retirement age on the age of onset (AOO) of Alzheimer's disease (AD).
METHODS NlmCategory: METHODS
Multiple regression analyses were carried out using data for 1320 probable AD cases, of which 382 were males with employment and retirement age data, using informant based information on education and employment.
RESULTS NlmCategory: RESULTS
No relation was found between years of education, best qualification obtained, or employment variables in males and the AOO of AD. A significant effect of later retirement age in delaying the AOO of AD was seen in males.
CONCLUSIONS NlmCategory: CONCLUSIONS
In this study no effect of education or employment was seen, although this may be due to limited variance in the study population. The significant effect of retirement age may have several explanations, the most interesting of which would be the suggestion that active employment later in life allows an individual to prolong their cognitive assets above the threshold for dementia.
(c) 2009 John Wiley & Sons, Ltd.
DATE PUBLISHED
2010 Jan
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2009/05/22 09:00
pubmed 2009/05/22 09:00
medline 2011/01/14 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Lupton MK Lupton Michelle K MK Department of Neuroscience, Institute of Psychiatry, Kings College London, UK. michelle.lupton@iop.kcl.ac.uk
Stahl D Stahl Daniel D
Archer N Archer Nicola N
Foy C Foy Catherine C
Poppe M Poppe Michaela M
Lovestone S Lovestone Simon S
Hollingworth P Hollingworth Paul P
Williams J Williams Julie J
Owen MJ Owen Micheal J MJ
Dowzell K Dowzell Kimberley K
Abraham R Abraham Richard R
Sims R Sims Rebecca R
Brayne C Brayne Carol C
Rubinsztein D Rubinsztein David D
Gill M Gill Michael M
Lawlor B Lawlor Brian B
Lynch A Lynch Aoibhinn A
Powell JF Powell John F JF
INVESTIGATORS
JOURNAL
VOLUME: 25
ISSUE: 1
TITLE: International journal of geriatric psychiatry
ISOABBREVIATION: Int J Geriatr Psychiatry
YEAR: 2010
MONTH: Jan
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1099-1166
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Int J Geriatr Psychiatry
COUNTRY: England
ISSNLINKING: 0885-6230
NLMUNIQUEID: 8710629
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
064354 Wellcome Trust United Kingdom
G0300429 Medical Research Council United Kingdom
Medical Research Council United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Age Factors
Age of Onset
Aged
Aged, 80 and over
Alzheimer Disease psychology
Cohort Studies psychology
Educational Status psychology
Employment psychology
Female psychology
Humans psychology
Male psychology
Middle Aged psychology
Regression Analysis psychology
Retirement psychology
Risk Factors psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's