Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
19446645
TITLE
Mapping the regional influence of genetics on brain structure variability--a tensor-based morphometry study.
ABSTRACT
Genetic and environmental factors influence brain structure and function profoundly. The search for heritable anatomical features and their influencing genes would be accelerated with detailed 3D maps showing the degree to which brain morphometry is genetically determined. As part of an MRI study that will scan 1150 twins, we applied Tensor-Based Morphometry to compute morphometric differences in 23 pairs of identical twins and 23 pairs of same-sex fraternal twins (mean age: 23.8+/-1.8 SD years). All 92 twins' 3D brain MRI scans were nonlinearly registered to a common space using a Riemannian fluid-based warping approach to compute volumetric differences across subjects. A multi-template method was used to improve volume quantification. Vector fields driving each subject's anatomy onto the common template were analyzed to create maps of local volumetric excesses and deficits relative to the standard template. Using a new structural equation modeling method, we computed the voxelwise proportion of variance in volumes attributable to additive (A) or dominant (D) genetic factors versus shared environmental (C) or unique environmental factors (E). The method was also applied to various anatomical regions of interest (ROIs). As hypothesized, the overall volumes of the brain, basal ganglia, thalamus, and each lobe were under strong genetic control; local white matter volumes were mostly controlled by common environment. After adjusting for individual differences in overall brain scale, genetic influences were still relatively high in the corpus callosum and in early-maturing brain regions such as the occipital lobes, while environmental influences were greater in frontal brain regions that have a more protracted maturational time-course.
DATE PUBLISHED
2009 Oct 15
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2008/12/06
revised 2009/05/04
accepted 2009/05/05
aheadofprint 2009/05/14
entrez 2009/05/19 09:00
pubmed 2009/05/19 09:00
medline 2009/10/27 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Brun CC Brun Caroline C CC Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, 635 Charles Young Drive South Suite 225, Los Angeles, CA 90095-7334, USA.
Leporé N Leporé Natasha N
Pennec X Pennec Xavier X
Lee AD Lee Agatha D AD
Barysheva M Barysheva Marina M
Madsen SK Madsen Sarah K SK
Avedissian C Avedissian Christina C
Chou YY Chou Yi-Yu YY
de Zubicaray GI de Zubicaray Greig I GI
McMahon KL McMahon Katie L KL
Wright MJ Wright Margaret J MJ
Toga AW Toga Arthur W AW
Thompson PM Thompson Paul M PM
INVESTIGATORS
JOURNAL
VOLUME: 48
ISSUE: 1
TITLE: NeuroImage
ISOABBREVIATION: Neuroimage
YEAR: 2009
MONTH: Oct
DAY: 15
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1095-9572
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Neuroimage
COUNTRY: United States
ISSNLINKING: 1053-8119
NLMUNIQUEID: 9215515
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
R01 HD050735 NICHD NIH HHS United States
R01 HD050735 NICHD NIH HHS United States
R01 HD050735-02 NICHD NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Brain anatomy & histology
Environment anatomy & histology
Female anatomy & histology
Humans anatomy & histology
Image Processing, Computer-Assisted anatomy & histology
Magnetic Resonance Imaging methods
Male methods
Models, Neurological methods
Organ Size methods
Phenotype methods
Sequence Analysis, DNA methods
Twins, Dizygotic methods
Twins, Monozygotic methods
Young Adult methods
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS126680 NLM
PMC2859973 NLM
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Last Modified: Oct 15 2007