Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
19418212
TITLE
Genetic covariation between theAuthor Recognition Test and reading and verbal abilities: what can we learn from the analysis of high performance?
ABSTRACT
The Author Recognition Test (ART) measures print exposure and is a unique predictor of phonological and orthographic processes in reading. In a sample of adolescent and young adult twins and siblings (216 MZ/430 DZ pairs, 307 singletons; aged 11-29 years) ART scores were moderately heritable (67%) and correlated with reading and verbal abilities, with genes largely accounting for the covariance. We also examine whether high (and low) (i.e. 1SD above the mean) represents a quantitative extreme of the normal distribution. Heritability for high ART was of similar magnitude to the full sample, but, a specific genetic factor, independent from both low ART performance and high reading ability, accounted for 53-58% of the variance. This suggests a distinct genetic etiology for high ART ability and we speculate that the specific genetic influence is on orthographical processing, a critical factor in developing word recognition skills.
DATE PUBLISHED
2009 Jul
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2008/11/25
accepted 2009/04/20
entrez 2009/05/07 09:00
pubmed 2009/05/07 09:00
medline 2009/10/06 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Martin NW Martin Nicolas W NW Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, QLD, Australia. nico.martin@qimr.edu.au
Hansell NK Hansell Narelle K NK
Wainwright MA Wainwright Mark A MA
Shekar SN Shekar Sri N SN
Medland SE Medland Sarah E SE
Bates TC Bates Timothy C TC
Burt JS Burt Jennifer S JS
Martin NG Martin Nicholas G NG
Wright MJ Wright Margaret J MJ
INVESTIGATORS
JOURNAL
VOLUME: 39
ISSUE: 4
TITLE: Behavior genetics
ISOABBREVIATION: Behav Genet
YEAR: 2009
MONTH: Jul
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1573-3297
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Behav Genet
COUNTRY: United States
ISSNLINKING: 0001-8244
NLMUNIQUEID: 0251711
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
CZB/4/536 Chief Scientist Office United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Analysis of Variance
Aptitude
Aptitude Tests
Child
Child, Gifted psychology
Epistasis, Genetic genetics
Female genetics
Genotype genetics
Humans genetics
Intelligence genetics
Male genetics
Models, Genetic genetics
Phenotype genetics
Phonetics genetics
Queensland genetics
Reading genetics
Recognition, Psychology genetics
Siblings psychology
Social Environment psychology
Twins, Dizygotic genetics
Twins, Monozygotic genetics
Verbal Learning genetics
Vocabulary genetics
Young Adult genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's