Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
19265028
TITLE
Geographical structure and differential natural selection among North European populations.
ABSTRACT
Population structure can provide novel insight into the human past, and recognizing and correcting for such stratification is a practical concern in gene mapping by many association methodologies. We investigate these patterns, primarily through principal component (PC) analysis of whole genome SNP polymorphism, in 2099 individuals from populations of Northern European origin (Ireland, United Kingdom, Netherlands, Denmark, Sweden, Finland, Australia, and HapMap European-American). The major trends (PC1 and PC2) demonstrate an ability to detect geographic substructure, even over a small area like the British Isles, and this information can then be applied to finely dissect the ancestry of the European-Australian and European-American samples. They simultaneously point to the importance of considering population stratification in what might be considered a small homogeneous region. There is evidence from F(ST)-based analysis of genic and nongenic SNPs that differential positive selection has operated across these populations despite their short divergence time and relatively similar geographic and environmental range. The pressure appears to have been focused on genes involved in immunity, perhaps reflecting response to infectious disease epidemic. Such an event may explain a striking selective sweep centered on the rs2508049-G allele, close to the HLA-G gene on chromosome 6. Evidence of the sweep extends over a 8-Mb/3.5-cM region. Overall, the results illustrate the power of dense genotype and sample data to explore regional population variation, the events that have crafted it, and their implications in both explaining disease prevalence and mapping these genes by association.
DATE PUBLISHED
2009 May
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2009/03/05
entrez 2009/03/07 09:00
pubmed 2009/03/07 09:00
medline 2009/09/23 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
McEvoy BP McEvoy Brian P BP Queensland Institute of Medical Research, Brisbane, Queensland, Australia. brian.mcevoy@qimr.edu.au
Montgomery GW Montgomery Grant W GW
McRae AF McRae Allan F AF
Ripatti S Ripatti Samuli S
Perola M Perola Markus M
Spector TD Spector Tim D TD
Cherkas L Cherkas Lynn L
Ahmadi KR Ahmadi Kourosh R KR
Boomsma D Boomsma Dorret D
Willemsen G Willemsen Gonneke G
Hottenga JJ Hottenga Jouke J JJ
Pedersen NL Pedersen Nancy L NL
Magnusson PK Magnusson Patrik K E PK
Kyvik KO Kyvik Kirsten Ohm KO
Christensen K Christensen Kaare K
Kaprio J Kaprio Jaakko J
Heikkilä K Heikkilä Kauko K
Palotie A Palotie Aarno A
Widen E Widen Elisabeth E
Muilu J Muilu Juha J
Syvänen AC Syvänen Ann-Christine AC
Liljedahl U Liljedahl Ulrika U
Hardiman O Hardiman Orla O
Cronin S Cronin Simon S
Peltonen L Peltonen Leena L
Martin NG Martin Nicholas G NG
Visscher PM Visscher Peter M PM
INVESTIGATORS
JOURNAL
VOLUME: 19
ISSUE: 5
TITLE: Genome research
ISOABBREVIATION: Genome Res.
YEAR: 2009
MONTH: May
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1088-9051
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Genome Res
COUNTRY: United States
ISSNLINKING: 1088-9051
NLMUNIQUEID: 9518021
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
Department of Health United Kingdom
Biotechnology and Biological Sciences Research Council United Kingdom
Wellcome Trust United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Europe
European Continental Ancestry Group genetics
Genetics, Population genetics
Genome-Wide Association Study genetics
Genotype genetics
Geography genetics
Humans genetics
Polymorphism, Single Nucleotide genetics
Principal Component Analysis genetics
Selection, Genetic genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC2675969 NLM