Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
About GenEpi
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
19265028
TITLE
Geographical structure and differential natural selection among North European populations.
ABSTRACT
Population structure can provide novel insight into the human past, and recognizing and correcting for such stratification is a practical concern in gene mapping by many association methodologies. We investigate these patterns, primarily through principal component (PC) analysis of whole genome SNP polymorphism, in 2099 individuals from populations of Northern European origin (Ireland, United Kingdom, Netherlands, Denmark, Sweden, Finland, Australia, and HapMap European-American). The major trends (PC1 and PC2) demonstrate an ability to detect geographic substructure, even over a small area like the British Isles, and this information can then be applied to finely dissect the ancestry of the European-Australian and European-American samples. They simultaneously point to the importance of considering population stratification in what might be considered a small homogeneous region. There is evidence from F(ST)-based analysis of genic and nongenic SNPs that differential positive selection has operated across these populations despite their short divergence time and relatively similar geographic and environmental range. The pressure appears to have been focused on genes involved in immunity, perhaps reflecting response to infectious disease epidemic. Such an event may explain a striking selective sweep centered on the rs2508049-G allele, close to the HLA-G gene on chromosome 6. Evidence of the sweep extends over a 8-Mb/3.5-cM region. Overall, the results illustrate the power of dense genotype and sample data to explore regional population variation, the events that have crafted it, and their implications in both explaining disease prevalence and mapping these genes by association.
DATE PUBLISHED
2009 May
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2009/03/05
entrez 2009/03/07 09:00
pubmed 2009/03/07 09:00
medline 2009/09/23 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
McEvoy BP McEvoy Brian P BP Queensland Institute of Medical Research, Brisbane, Queensland, Australia. brian.mcevoy@qimr.edu.au
Montgomery GW Montgomery Grant W GW
McRae AF McRae Allan F AF
Ripatti S Ripatti Samuli S
Perola M Perola Markus M
Spector TD Spector Tim D TD
Cherkas L Cherkas Lynn L
Ahmadi KR Ahmadi Kourosh R KR
Boomsma D Boomsma Dorret D
Willemsen G Willemsen Gonneke G
Hottenga JJ Hottenga Jouke J JJ
Pedersen NL Pedersen Nancy L NL
Magnusson PK Magnusson Patrik K E PK
Kyvik KO Kyvik Kirsten Ohm KO
Christensen K Christensen Kaare K
Kaprio J Kaprio Jaakko J
Heikkilä K Heikkilä Kauko K
Palotie A Palotie Aarno A
Widen E Widen Elisabeth E
Muilu J Muilu Juha J
Syvänen AC Syvänen Ann-Christine AC
Liljedahl U Liljedahl Ulrika U
Hardiman O Hardiman Orla O
Cronin S Cronin Simon S
Peltonen L Peltonen Leena L
Martin NG Martin Nicholas G NG
Visscher PM Visscher Peter M PM
INVESTIGATORS
JOURNAL
VOLUME: 19
ISSUE: 5
TITLE: Genome research
ISOABBREVIATION: Genome Res.
YEAR: 2009
MONTH: May
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1088-9051
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Genome Res
COUNTRY: United States
ISSNLINKING: 1088-9051
NLMUNIQUEID: 9518021
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Nat Genet. 2006 Oct;38(10):1166-72 16998491
Cites Eur J Hum Genet. 2008 Dec;16(12):1413-29 19020537
Cites Tissue Antigens. 2007 Mar;69(3):207-11 17493143
Cites Nature. 2007 Jun 7;447(7145):661-78 17554300
Cites PLoS Genet. 2006 Dec;2(12):e190 17194218
Cites Nature. 2007 Oct 18;449(7164):851-61 17943122
Cites Nature. 2000 Mar 23;404(6776):351-2 10746711
Cites Genetics. 2000 Jun;155(2):945-59 10835412
Cites Am J Hum Genet. 2000 Dec;67(6):1526-43 11078479
Cites Biometrics. 1999 Dec;55(4):997-1004 11315092
Cites Nature. 2002 Oct 24;419(6909):832-7 12397357
Cites Curr Biol. 2003 May 27;13(11):979-84 12781138
Cites Genetics. 2003 Aug;164(4):1567-87 12930761
Cites Genome Res. 2003 Sep;13(9):2129-41 12952881
Cites Twin Res. 2003 Oct;6(5):354-60 14624719
Cites Nat Genet. 2004 May;36(5):512-7 15052271
Cites Am J Hum Genet. 2004 Jun;74(6):1111-20 15114531
Cites Am J Hum Genet. 2004 Oct;75(4):693-702 15309688
Cites Cancer Res. 1967 Feb;27(2):209-20 6018555
Cites Am J Hum Genet. 2005 Feb;76(2):349-57 15611928
Cites Nature. 2005 Oct 27;437(7063):1299-320 16255080
Cites J Infect Dis. 2006 Jan 15;193(2):298-301 16362895
Cites Bioinformatics. 2006 Mar 1;22(5):626-7 16418238
Cites PLoS Biol. 2006 Mar;4(3):e72 16494531
Cites Am J Hum Genet. 2006 Apr;78(4):629-44 16532393
Cites Nat Genet. 2006 Aug;38(8):904-9 16862161
Cites Hum Mol Genet. 2006 Oct 15;15 Spec No 2:R176-81 16987881
Cites PLoS Genet. 2006 Sep 15;2(9):e143 17044734
Cites Nature. 2007 Oct 18;449(7164):913-8 17943131
Cites PLoS Genet. 2008 Jan;4(1):e236 18208327
Cites PLoS Genet. 2008 Jan;4(1):e4 18208329
Cites PLoS Genet. 2008 Jan;4(1):e5 18208330
Cites Am J Hum Genet. 2008 Feb;82(2):424-31 18252222
Cites Hum Mol Genet. 2008 Mar 1;17(5):768-74 18057069
Cites Nat Genet. 2008 Mar;40(3):340-5 18246066
Cites Nat Genet. 2008 May;40(5):646-9 18425127
Cites Curr Biol. 2008 Aug 26;18(16):1241-8 18691889
Cites Nature. 2008 Nov 6;456(7218):98-101 18758442
Cites Am J Hum Genet. 2007 May;80(5):948-56 17436249
GRANTS
GRANTID AGENCY COUNTRY
Department of Health United Kingdom
Biotechnology and Biological Sciences Research Council United Kingdom
Wellcome Trust United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Europe
European Continental Ancestry Group genetics
Genetics, Population genetics
Genome-Wide Association Study genetics
Genotype genetics
Geography genetics
Humans genetics
Polymorphism, Single Nucleotide genetics
Principal Component Analysis genetics
Selection, Genetic genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC2675969 NLM
Designed by: GenEpi IT
Maintained by: GenEpi IT
Feedback: webmaster
Copyright © 2007 QIMR
For more information Contact Us
epiit@qimr.edu.au
Last Modified: Oct 15 2007