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| PMID |
|
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| TITLE |
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| Flexible Mx specification of various extended twin kinship designs. |
|
| ABSTRACT |
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| The extended twin kinship design allows the simultaneous testing of additive and nonadditive genetic, shared and individual-specific environmental factors, as well as sex differences in the expression of genes and environment in the presence of assortative mating and combined genetic and cultural transmission (Eaves et al., 1999). It also handles the contribution of these sources of variance to the (co)variation of multiple phenotypes. Keller et al. (2008) extended this comprehensive model for family resemblance to allow or a flexible specification of assortment and vertical transmission. As such, it provides a general framework which can easily be reduced to fit subsets of data such as twin-parent data, children-of-twins data, etc. A flexible Mx specification of this model that allows handling of these various designs is presented in detail and applied to data from the Virginia 30,000. Data on height, body mass index, smoking status, church attendance, and political affiliation were obtained from twins and their families. Results indicate that biases in the estimation of variance components depend both on the types of relative available for analysis, and on the underlying genetic and environmental architecture of the phenotype of interest. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| entrez |
2009/02/13 09:00 |
| pubmed |
2009/02/13 09:00 |
| medline |
2009/08/19 09:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Maes HH |
|
Maes |
Hermine H |
HH |
|
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298-0003, United States of America. hmaes@vcu.edu |
| Neale MC |
|
Neale |
Michael C |
MC |
|
|
| Medland SE |
|
Medland |
Sarah E |
SE |
|
|
| Keller MC |
|
Keller |
Matthew C |
MC |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
| Heath AC |
|
Heath |
Andrew C |
AC |
|
|
| Eaves LJ |
|
Eaves |
Lindon J |
LJ |
|
|
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| INVESTIGATORS |
|
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| JOURNAL |
|
| VOLUME: 12 |
| ISSUE: 1 |
| TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res Hum Genet |
| YEAR: 2009 |
| MONTH: Feb |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1832-4274 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Twin Res Hum Genet |
| COUNTRY: England |
| ISSNLINKING: 1832-4274 |
| NLMUNIQUEID: 101244624 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
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| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
| Cites |
Behav Genet. 1997 Mar;27(2):113-20 |
9145549 |
|
| Cites |
Twin Res. 1999 Jun;2(2):99-107 |
10480744 |
|
| Cites |
Twin Res. 1999 Jun;2(2):169-79 |
10480751 |
|
| Cites |
Psychol Med. 2004 Oct;34(7):1251-61 |
15697051 |
|
| Cites |
Twin Res Hum Genet. 2005 Jun;8(3):201-13 |
15989748 |
|
| Cites |
Twin Res Hum Genet. 2009 Feb;12(1):8-18 |
19210175 |
|
| Cites |
Twin Res Hum Genet. 2009 Feb;12(1):19-25 |
19210176 |
|
| Cites |
Behav Genet. 2000 May;30(3):223-33 |
11105396 |
|
| Cites |
Am J Hum Genet. 1979 Mar;31(2):176-98 |
453202 |
|
| Cites |
Behav Genet. 1985 Jan;15(1):15-30 |
4039132 |
|
| Cites |
Genet Epidemiol. 1985;2(1):35-53 |
4054591 |
|
| Cites |
Behav Genet. 1994 Jan;24(1):35-49 |
8192619 |
|
| Cites |
Behav Genet. 1994 Mar;24(2):119-39 |
8024529 |
|
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| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| R01 MH068521-04 |
NIMH NIH HHS |
United States |
| DA018673 |
NIDA NIH HHS |
United States |
| R01 AA007535 |
NIAAA NIH HHS |
United States |
| CA093423 |
NCI NIH HHS |
United States |
| DA022989 |
NIDA NIH HHS |
United States |
| R01 AA007728 |
NIAAA NIH HHS |
United States |
| R01 DA024413 |
NIDA NIH HHS |
United States |
| DA024413 |
NIDA NIH HHS |
United States |
| R01 CA085739 |
NCI NIH HHS |
United States |
| T32 MH020030 |
NIMH NIH HHS |
United States |
| MH020030 |
NIMH NIH HHS |
United States |
| GM30250 |
NIGMS NIH HHS |
United States |
| U01 DA024413 |
NIDA NIH HHS |
United States |
| AA06781 |
NIAAA NIH HHS |
United States |
| MH40828 |
NIMH NIH HHS |
United States |
| R01 MH068521 |
NIMH NIH HHS |
United States |
| U01 DA024413-02 |
NIDA NIH HHS |
United States |
| R37 DA018673 |
NIDA NIH HHS |
United States |
| R01 AA006781 |
NIAAA NIH HHS |
United States |
| CA085739 |
NCI NIH HHS |
United States |
| MH068521 |
NIMH NIH HHS |
United States |
| R01 DA016977-03 |
NIDA NIH HHS |
United States |
| AA07728 |
NIAAA NIH HHS |
United States |
| DA016977 |
NIDA NIH HHS |
United States |
| R25 CA093423 |
NCI NIH HHS |
United States |
| R25 CA093423-05 |
NCI NIH HHS |
United States |
| R37 DA018673-02 |
NIDA NIH HHS |
United States |
| R01 DA018673 |
NIDA NIH HHS |
United States |
| AG04954 |
NIA NIH HHS |
United States |
| R37 AA007728 |
NIAAA NIH HHS |
United States |
| R01 DA016977 |
NIDA NIH HHS |
United States |
| R01 MH040828 |
NIMH NIH HHS |
United States |
| GM32732 |
NIGMS NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
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| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Analysis of Variance |
|
| Body Height |
genetics |
| Body Mass Index |
genetics |
| Databases, Genetic |
genetics |
| Environment |
genetics |
| Family |
genetics |
| Female |
genetics |
| Humans |
genetics |
| Male |
genetics |
| Models, Genetic |
genetics |
| Phenotype |
genetics |
| Smoking |
genetics |
| Socioeconomic Factors |
genetics |
| Twins |
genetics |
| Virginia |
genetics |
|
| SUPPLEMENTARY MESH |
|
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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