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| PMID |
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| TITLE |
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| Family-based genome-wide association studies. |
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| ABSTRACT |
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| In the last 2 years, the effort to identify genes affecting common diseases and complex traits has been accelerated through the use of genome-wide association studies (GWAS). The availability of existing large collections of linkage data paved the way for the use of family-based GWAS. Although most published GWAS used population-based designs, family-based designs have played an important role, particularly in replication stages. Family-based designs offer advantages in terms of quality control, the robustness to population stratification and the ability to perform genetic analyses that cannot be achieved using a sample of unrelated individuals, such as testing for the effect of imprinted genes on phenotypes, testing whether a genetic variant is inherited or de novo and combined linkage and association analysis. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| entrez |
2009/02/12 09:00 |
| pubmed |
2009/02/12 09:00 |
| medline |
2009/05/19 09:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Benyamin B |
|
Benyamin |
Beben |
B |
|
Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, QLD 4029, Australia. bebenB@qimr.edu.au |
| Visscher PM |
|
Visscher |
Peter M |
PM |
|
|
| McRae AF |
|
McRae |
Allan F |
AF |
|
|
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| INVESTIGATORS |
|
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| JOURNAL |
|
| VOLUME: 10 |
| ISSUE: 2 |
| TITLE: Pharmacogenomics |
| ISOABBREVIATION: Pharmacogenomics |
| YEAR: 2009 |
| MONTH: Feb |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1744-8042 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Pharmacogenomics |
| COUNTRY: England |
| ISSNLINKING: 1462-2416 |
| NLMUNIQUEID: 100897350 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
| Review |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Chromosome Mapping |
|
| Family |
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| Female |
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| Genetic Diseases, Inborn |
genetics |
| Genetic Variation |
genetics |
| Genome, Human |
genetics |
| Genome-Wide Association Study |
methods |
| Genomic Imprinting |
methods |
| Humans |
methods |
| Male |
methods |
| Pedigree |
methods |
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| SUPPLEMENTARY MESH |
|
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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