Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
19193628
TITLE
ADH single nucleotide polymorphism associations with alcohol metabolism in vivo.
ABSTRACT
We have previously found that variation in alcohol metabolism in Europeans is linked to the chromosome 4q region containing the ADH gene family. We have now typed 103 single nucleotide polymorphisms (SNPs) across this region to test for allelic associations with variation in blood and breath alcohol concentrations after an alcohol challenge. In vivo alcohol metabolism was modelled with three parameters that identified the absorption and rise of alcohol concentration following ingestion, and the rate of elimination. Alleles of ADH7 SNPs were associated with the early stages of alcohol metabolism, with additional effects in the ADH1A, ADH1B and ADH4 regions. Rate of elimination was associated with SNPs in the intragenic region between ADH7 and ADH1C, and across ADH1C and ADH1B. SNPs affecting alcohol metabolism did not correspond to those reported to affect alcohol dependence or alcohol-related disease. The combined SNP associations with early- and late-stage metabolism only account for approximately 20% of the total genetic variance linked to the ADH region, and most of the variance for in vivo alcohol metabolism linked to this region is yet to be explained.
DATE PUBLISHED
2009 Apr 15
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2009/02/04
entrez 2009/02/06 09:00
pubmed 2009/02/06 09:00
medline 2009/07/07 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Birley AJ Birley Andrew J AJ Genetic Epidemiology Unit, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia.
James MR James Michael R MR
Dickson PA Dickson Peter A PA
Montgomery GW Montgomery Grant W GW
Heath AC Heath Andrew C AC
Martin NG Martin Nicholas G NG
Whitfield JB Whitfield John B JB
INVESTIGATORS
JOURNAL
VOLUME: 18
ISSUE: 8
TITLE: Human molecular genetics
ISOABBREVIATION: Hum. Mol. Genet.
YEAR: 2009
MONTH: Apr
DAY: 15
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1460-2083
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Hum Mol Genet
COUNTRY: England
ISSNLINKING: 0964-6906
NLMUNIQUEID: 9208958
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Prog Nucleic Acid Res Mol Biol. 2000;64:295-341 10697413
Cites J Biol Chem. 2006 Jul 21;281(29):19809-21 16675441
Cites Br J Clin Pharmacol. 2000 May;49(5):399-408 10792196
Cites Am J Hum Genet. 1999 Oct;65(4):1148-60 10486334
Cites Alcohol Clin Exp Res. 2001 Sep;25(9):1257-63 11584143
Cites J Korean Med Sci. 2001 Dec;16(6):745-50 11748356
Cites Nat Genet. 2002 Jan;30(1):97-101 11731797
Cites Am J Hum Genet. 2002 Nov;71(5):1247-50; author reply 1250-1 12452180
Cites J Stud Alcohol. 2003 Mar;64(2):176-81 12713190
Cites Alcohol Clin Exp Res. 2004 Jan;28(1):10-4 14745297
Cites Clin Pharmacol Ther. 1971 Mar-Apr;12(2):192-201 5102974
Cites Eur J Clin Pharmacol. 1977;11(5):337-44 560303
Cites Eur J Clin Pharmacol. 1984;26(5):619-26 6468479
Cites Alcohol. 1985 Jan-Feb;2(1):53-6 3893465
Cites Alcohol. 1984 Sep-Oct;1(5):385-91 6537224
Cites Hepatology. 1986 May-Jun;6(3):502-10 3519419
Cites Behav Genet. 1985 Mar;15(2):93-109 3838073
Cites Arukoru Kenkyuto Yakubutsu Ison. 1993 Feb;28(1):13-25 8512495
Cites Br J Clin Pharmacol. 1994 May;37(5):427-31 8054248
Cites Eur J Biochem. 1994 Sep 1;224(2):549-57 7925371
Cites Alcohol Alcohol. 1994 Nov;29(6):707-10 7695788
Cites Alcohol Clin Exp Res. 1995 Dec;19(6):1494-9 8749816
Cites Br J Psychiatry. 1996 Jun;168(6):762-7 8773821
Cites Alcohol Alcohol Suppl. 1994;2:29-34 8974313
Cites Am J Med Genet. 1998 May 8;81(3):207-15 9603606
Cites Am J Med Genet. 1998 May 8;81(3):216-21 9603607
Cites Alcohol Clin Exp Res. 1998 Oct;22(7):1463-9 9802529
Cites Am J Hum Genet. 1999 Apr;64(4):1147-57 10090900
Cites Pharmacogenetics. 1999 Feb;9(1):25-30 10208639
Cites Hum Mutat. 2005 Feb;25(2):150-5 15643610
Cites Drug Alcohol Depend. 2006 Sep 15;84(2):195-200 16600530
Cites Alcohol Clin Exp Res. 2007 Feb;31(2):216-20 17250612
Cites Alcohol Res Health. 2007;30(1):22-7 17718397
Cites Nat Genet. 2007 Oct;39(10):1202-7 17873877
Cites Hum Mol Genet. 2008 Jan 15;17(2):179-89 17921519
Cites Alcohol Clin Exp Res. 2008 May;32(5):785-95 18331377
Cites Nat Genet. 2008 Jun;40(6):707-9 18500343
Cites PLoS Biol. 2008 May 6;6(5):e107 18462017
Cites Hum Mol Genet. 2009 Feb 1;18(3):580-93 18996923
Cites Bioinformatics. 2005 Aug 15;21(16):3445-7 15947021
Cites Hum Mutat. 2005 Sep;26(3):224-34 16086315
Cites Heredity (Edinb). 2005 Sep;95(3):184-97 16121213
Cites Behav Genet. 2005 Sep;35(5):509-24 16184481
Cites Hum Mol Genet. 2006 May 1;15(9):1539-49 16571603
Cites Hum Genet. 2006 Jun;119(5):558-70 16604350
Cites Am J Hum Genet. 2006 Jun;78(6):973-87 16685648
Cites Hepatology. 2000 Apr;31(4):984-9 10733556
GRANTS
GRANTID AGENCY COUNTRY
A014041 PHS HHS United States
AA007535 NIAAA NIH HHS United States
AA007728 NIAAA NIH HHS United States
AA011998 NIAAA NIH HHS United States
AA013321 NIAAA NIH HHS United States
AA013326 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Alcohol Dehydrogenase genetics
Alcoholism genetics
Humans genetics
Polymorphism, Single Nucleotide genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
EC 1.1.1.1 ADH1B protein, human
EC 1.1.1.1 ADH1C protein, human
EC 1.1.1.1 ADH7 protein, human
EC 1.1.1.1 Alcohol Dehydrogenase
OTHER ID's
OTHERID SOURCE
PMC2664151 NLM
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