Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
19183129
TITLE
Can we identify genes for alcohol consumption in samples ascertained for heterogeneous purposes?
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Previous studies have identified evidence of genetic influence on alcohol use in samples selected to be informative for alcoholism research. However, there are a growing number of genome-wide association studies (GWAS) using samples unselected for alcohol consumption (i.e., selected on other traits and forms of psychopathology), which nevertheless assess consumption as a risk factor. Is it reasonable to expect that genes contributing to variation in alcohol consumption can be identified in such samples?
METHODS NlmCategory: METHODS
An exploratory approach was taken to determine whether linkage analyses for heaviness of alcohol consumption, using a sample collected for heterogeneous purposes, could replicate previous findings. Quantity and frequency measures of consumption were collected in telephone interviews from community samples. These measures, and genotyping, were available for 5,441 individuals (5,067 quasi-independent sibling pairs). For 1,533 of these individuals, data were collected on 2 occasions, about 8.2 years apart, providing 2 datasets that maximize data collected at either a younger or an older age. Analyses were conducted to address the question of whether age and heavier levels of alcohol consumption effects outcome. Linkage results were compared in the younger and older full samples, and with samples in which approximately 10, 20, and 40 of drinkers from the lower end of the distribution of alcohol consumption were dropped.
RESULTS NlmCategory: RESULTS
Linkage peaks varied for the age differentiated samples and for percentage of light drinkers retained. Larger peaks (LOD scores >2.0) were typically found in regions previously identified in linkage studies and/or containing proposed candidate genes for alcoholism including AGT, CARTPT, OPRD1, PIK3R1, and PDYN.
CONCLUSIONS NlmCategory: CONCLUSIONS
The results suggest that GWAS assessing alcohol consumption as a covariate for other conditions will have some success in identifying genes contributing to consumption-related variation. However, sample characteristics, such as participant age, and trait distribution, may have substantial effects on the strength of the genetic signal. These results can inform forthcoming GWAS where the same restrictions apply.
DATE PUBLISHED
2009 Apr
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2009/01/22
entrez 2009/02/03 09:00
pubmed 2009/02/03 09:00
medline 2009/07/08 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Hansell NK Hansell Narelle K NK Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia. Narelle.Hansell@qimr.edu.au
Agrawal A Agrawal Arpana A
Whitfield JB Whitfield John B JB
Morley KI Morley Katherine I KI
Gordon SD Gordon Scott D SD
Lind PA Lind Penelope A PA
Pergadia ML Pergadia Michele L ML
Montgomery GW Montgomery Grant W GW
Madden PA Madden Pamela A F PA
Todd RD Todd Richard D RD
Heath AC Heath Andrew C AC
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 33
ISSUE: 4
TITLE: Alcoholism, clinical and experimental research
ISOABBREVIATION: Alcohol. Clin. Exp. Res.
YEAR: 2009
MONTH: Apr
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1530-0277
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Alcohol Clin Exp Res
COUNTRY: England
ISSNLINKING: 0145-6008
NLMUNIQUEID: 7707242
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Am J Med Genet B Neuropsychiatr Genet. 2005 Apr 5;134B(1):48-55 15704214
Cites Twin Res Hum Genet. 2006 Apr;9(2):194-7 16611487
Cites Bioinformatics. 2005 Aug 15;21(16):3445-7 15947021
Cites Twin Res Hum Genet. 2005 Aug;8(4):362-7 16176721
Cites Twin Res Hum Genet. 2005 Dec;8(6):616-32 16363087
Cites Genome. 2006 Jan;49(1):1-7 16462896
Cites Behav Genet. 2006 Jan;36(1):7-11 16502136
Cites Behav Genet. 2006 Jan;36(1):4-6 16523245
Cites Addict Biol. 2006 Sep;11(3-4):386-96 16961766
Cites Mol Psychiatry. 2006 Nov;11(11):1016-24 16924269
Cites Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141B(8):844-53 16894614
Cites Pharmacogenomics J. 2007 Aug;7(4):222-56 17033615
Cites Addict Biol. 2007 Sep;12(3-4):496-502 17559549
Cites Alcohol Res Health. 2007;30(1):5-13 17718394
Cites Am J Hum Genet. 1999 Dec;65(6):1733-40 10577928
Cites Am J Med Genet B Neuropsychiatr Genet. 2007 Oct 5;144B(7):877-84 17503481
Cites Biochem Pharmacol. 2008 Jan 1;75(1):98-111 17764662
Cites Drug Alcohol Depend. 2008 Jan 11;93(1-2):12-20 17942244
Cites J Intern Med. 2008 Jan;263(1):16-27 18088250
Cites Eur J Cancer Prev. 2008 Apr;17(2):116-24 18287868
Cites Nat Rev Drug Discov. 2008 Mar;7(3):221-30 18274536
Cites PLoS One. 2008;3(3):e1769 18335044
Cites Eur J Hum Genet. 2008 Apr;16(4):516-24 18197190
Cites PLoS Med. 2008 Mar 4;5(3):e52 18318597
Cites Mol Psychiatry. 2008 May;13(5):531-43 17622222
Cites Am J Med. 2008 May;121(5):406-18 18456037
Cites Eur J Epidemiol. 2008;23(6):395-401 18409007
Cites Twin Res Hum Genet. 2008 Jun;11(3):287-305 18498207
Cites Hum Mol Genet. 2009 Feb 1;18(3):580-93 18996923
Cites Am J Hum Genet. 2000 Nov;67(5):1219-31 11032786
Cites Alcohol Clin Exp Res. 2000 Dec;24(12):1873-82 11141048
Cites FASEB J. 2001 Jul;15(9):1640-2 11427512
Cites Bioinformatics. 2001 Aug;17(8):742-3 11524377
Cites Nat Genet. 2002 Jan;30(1):97-101 11731797
Cites Am J Hum Genet. 2002 Aug;71(2):238-53 12111667
Cites Alcohol Clin Exp Res. 2002 Oct;26(10):1453-60 12394277
Cites J Neurosci Res. 2003 Jun 15;72(6):756-67 12774316
Cites BMC Psychiatry. 2002 Jul 3;2:8 12095426
Cites BMC Genet. 2003;4 Suppl 1:S106 14975174
Cites Am J Hum Genet. 2004 Apr;74(4):705-14 15024690
Cites Am J Med Genet B Neuropsychiatr Genet. 2004 Jul 1;128B(1):102-13 15211641
Cites Neurosci Lett. 2004 Jul 15;365(1):54-7 15234472
Cites Neurosci Res. 2004 Aug;49(4):379-85 15236863
Cites J Neurosci Methods. 2004 Sep 30;138(1-2):173-88 15325126
Cites Behav Genet. 1972 Mar;2(1):3-19 4157472
Cites Alcohol Clin Exp Res. 1993 Feb;17(1):99-106 8095774
Cites Genet Epidemiol. 1993;10(3):201-13 8349101
Cites Ann N Y Acad Sci. 1994 Feb 28;708:72-85 8154691
Cites J Stud Alcohol. 1994 Mar;55(2):149-58 8189735
Cites Am J Med Genet. 1998 May 8;81(3):207-15 9603606
Cites Am J Med Genet. 1998 May 8;81(3):216-21 9603607
Cites Arch Gen Psychiatry. 2004 Dec;61(12):1246-56 15583116
Cites Psychiatr Genet. 2005 Mar;15(1):71-5 15722961
Cites BMC Genet. 2005;6 Suppl 1:S112 16451569
Cites BMC Genet. 2005;6 Suppl 1:S8 16451694
Cites J Neurochem. 2005 Apr;93(2):359-70 15816859
GRANTS
GRANTID AGENCY COUNTRY
AA014041 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
AA10248 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
AA13320 NIAAA NIH HHS United States
AA13321 NIAAA NIH HHS United States
AA13326 NIAAA NIH HHS United States
DA019951 NIDA NIH HHS United States
DA023668 NIDA NIH HHS United States
DA12854 NIDA NIH HHS United States
K08 DA019951 NIDA NIH HHS United States
K08 DA019951-04 NIDA NIH HHS United States
P50 AA011998 NIAAA NIH HHS United States
P50 AA011998-10 NIAAA NIH HHS United States
R01 AA010249 NIAAA NIH HHS United States
R01 AA010249-04 NIAAA NIH HHS United States
R01 AA013320-04 NIAAA NIH HHS United States
R01 AA013321 NIAAA NIH HHS United States
R01 AA013321-05 NIAAA NIH HHS United States
R01 AA013326-05 NIAAA NIH HHS United States
R01 AA014041-05 NIAAA NIH HHS United States
R01 DA012854 NIDA NIH HHS United States
R01 DA012854-05 NIDA NIH HHS United States
R01 DA023668 NIDA NIH HHS United States
R01 DA023668-02 NIDA NIH HHS United States
R37 AA007728 NIAAA NIH HHS United States
R37 AA007728-20 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Age Factors
Aged
Aged, 80 and over
Alcohol Drinking genetics
Angiotensinogen genetics
Australia genetics
Data Collection genetics
Enkephalins genetics
Female genetics
Genetic Heterogeneity genetics
Genetic Linkage genetics
Genetic Predisposition to Disease genetics
Genotype genetics
Humans genetics
Interviews as Topic genetics
Linear Models genetics
Male genetics
Middle Aged genetics
Protein Precursors genetics
Receptors, Opioid, delta genetics
Young Adult genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 AGT protein, human
0 Enkephalins
0 OPRD1 protein, human
0 Protein Precursors
0 Receptors, Opioid, delta
11002-13-4 Angiotensinogen
93443-35-7 preproenkephalin
OTHER ID's
OTHERID SOURCE
NIHMS314587 NLM
PMC3164813 NLM