Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
19180564
TITLE
Genetic linkage findings for DSM-IV nicotine withdrawal in two populations.
ABSTRACT
Nicotine withdrawal (NW) is both an important contributor to difficulty quitting cigarettes and because of mood-related withdrawal symptoms a problem of particular relevance to psychiatry. Twin-studies suggest that genetic factors influence NW (heritability = 45%). Only one previous linkage study has published findings on NW [Swan et al. (2006); Am J Med Genet Part B 141B:354-360; LOD = 2.7; Chr. 6 at 159 cM]. As part of an international consortium, genome-wide scans (using over 360 autosomal microsatellite markers) and telephone diagnostic interviews were conducted on 289 Australian (AUS) and 161 Finnish (FIN, combined (COMB) N = 450 families) families ascertained from twin registries through index-cases with a lifetime history of cigarette smoking. The statistical approach used an affected-sib-pair design (at least two adult full siblings reported a history of DSM-IV NW) and conducted the linkage analyses using MERLIN. Linkage signals with LOD scores >1.5 were found on two chromosomes: 6 (FIN: LOD = 1.93 at 75 cM) and 11 at two different locations (FIN: LOD = 3.55 at 17 cM, and AUS: LOD = 1.68 with a COMB: LOD = 2.30 at 123 cM). The multipoint LOD score of 3.55 on chromosome 11p15 in FIN met genomewide significance (P = 0.013 with 1,000 simulations). At least four strong candidate genes lie within or near this peak on chromosome 11: DRD4, TPH, TH, and CHRNA10. Other studies have reported that chromosome 11 may harbor genes associated with various aspects of smoking behavior. This study adds to that literature by highlighting evidence for NW.
(c) 2009 Wiley-Liss, Inc.
DATE PUBLISHED
2009 Oct 5
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2009/01/31 09:00
pubmed 2009/01/31 09:00
medline 2009/12/29 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Pergadia ML Pergadia Michele L ML Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri 63110, USA. pergadim@psychiatry.wustl.edu
Agrawal A Agrawal Arpana A
Loukola A Loukola Anu A
Montgomery GW Montgomery Grant W GW
Broms U Broms Ulla U
Saccone SF Saccone Scott F SF
Wang JC Wang Jen C JC
Todorov AA Todorov Alexandre A AA
Heikkilä K Heikkilä Kauko K
Statham DJ Statham Dixie J DJ
Henders AK Henders Anjali K AK
Campbell MJ Campbell Megan J MJ
Rice JP Rice John P JP
Todd RD Todd Richard D RD
Heath AC Heath Andrew C AC
Goate AM Goate Alison M AM
Peltonen L Peltonen Leena L
Kaprio J Kaprio Jaakko J
Martin NG Martin Nicholas G NG
Madden PA Madden Pamela A F PA
INVESTIGATORS
JOURNAL
VOLUME: 150B
ISSUE: 7
TITLE: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
ISOABBREVIATION: Am. J. Med. Genet. B Neuropsychiatr. Genet.
YEAR: 2009
MONTH: Oct
DAY: 5
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1552-485X
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Am J Med Genet B Neuropsychiatr Genet
COUNTRY: United States
ISSNLINKING: 1552-4841
NLMUNIQUEID: 101235742
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Nicotine Tob Res. 2007 Aug;9(8):821-33 17654295
Cites J Public Health (Oxf). 2008 Dec;30(4):407-14 18003652
Cites Nat Rev Genet. 2000 Dec;1(3):182-90 11252747
Cites Am J Med Genet. 2001 Jul 8;105(5):479-84 11449402
Cites Am J Med Genet. 2001 Aug 8;105(6):518-20 11496367
Cites Nat Genet. 2002 Jan;30(1):97-101 11731797
Cites MMWR Morb Mortal Wkly Rep. 2002 Apr 12;51(14):300-3 12002168
Cites Nat Genet. 2002 Jul;31(3):241-7 12053178
Cites J Abnorm Psychol. 2003 Feb;112(1):14-27 12653410
Cites Am J Med Genet A. 2004 Jan 1;124A(1):19-27 14679582
Cites BMC Genet. 2003;4 Suppl 1:S101 14975169
Cites BMC Genet. 2003;4 Suppl 1:S102 14975170
Cites BMC Genet. 2003;4 Suppl 1:S103 14975171
Cites BMC Genet. 2003;4 Suppl 1:S105 14975173
Cites Hum Mutat. 2004 Jun;23(6):540-5 15146457
Cites Am J Med Genet B Neuropsychiatr Genet. 2004 Jul 1;128B(1):94-101 15211640
Cites Pharmacogenomics J. 2004;4(4):274-82 15170444
Cites Prev Med. 1985 Mar;14(2):195-202 4048082
Cites Br J Addict. 1989 Jul;84(7):791-9 2758152
Cites Br J Addict. 1991 Sep;86(9):1119-27 1932883
Cites Br J Psychiatry. 1991 Nov;159:653-8 1756341
Cites Alcohol. 1991 Sep-Oct;8(5):409-16 1839129
Cites Am J Psychiatry. 1992 Apr;149(4):464-9 1554030
Cites Lancet. 1992 May 23;339(8804):1268-78 1349675
Cites J Stud Alcohol. 1994 Mar;55(2):149-58 8189735
Cites Am J Hum Genet. 1997 Aug;61(2):423-9 9311748
Cites Genet Epidemiol. 1999;17 Suppl 1:S55-60 10597412
Cites Genet Epidemiol. 1999;17 Suppl 1:S139-44 10597426
Cites Addiction. 1999 Sep;94(9):1361-70 10615721
Cites Am J Hum Genet. 2000 Mar;66(3):1076-94 10712219
Cites Nature. 2000 Jun 15;405(6788):847-56 10866211
Cites Am J Med Genet. 1998 Feb 7;81(1):13-7 9514581
Cites J Abnorm Psychol. 1998 May;107(2):238-51 9604553
Cites Am J Hum Genet. 1998 Jul;63(1):259-66 9634505
Cites Arch Gen Psychiatry. 1998 Jul;55(7):593-602 9672049
Cites Am J Hum Genet. 1998 Nov;63(5):1563-4 9792888
Cites Mol Psychiatry. 1999 Mar;4(2):129-44 10208445
Cites Pharmacogenomics J. 2005;5(3):166-72 15724146
Cites Mol Psychiatry. 2006 Mar;11(3):312-22, 223 16314871
Cites BMC Med Genet. 2006;7:9 16472381
Cites Behav Genet. 2006 Jan;36(1):87-99 16365831
Cites Am J Med Genet B Neuropsychiatr Genet. 2006 Jun 5;141B(4):354-60 16671072
Cites Psychol Med. 2006 Jul;36(7):963-72 16749946
Cites Nicotine Tob Res. 2006 Apr;8(2):153-6 16766409
Cites Behav Genet. 2006 Jul;36(4):567-76 16477519
Cites Am J Hum Genet. 2006 Oct;79(4):745-51 16960812
Cites MMWR Morb Mortal Wkly Rep. 2006 Oct 27;55(42):1145-8 17065979
Cites Pharmacogenet Genomics. 2006 Dec;16(12):901-10 17108814
Cites Hum Mol Genet. 2006 Dec 15;15(24):3498-507 17085484
Cites Biol Psychiatry. 2007 Jan 1;61(1):119-26 17081504
Cites Hum Mol Genet. 2007 Jan 1;16(1):36-49 17135278
Cites Hum Mol Genet. 2007 Jan 1;16(1):24-35 17158188
Cites Am J Hum Genet. 2007 May;80(5):856-66 17436240
Cites Health Psychol. 2007 May;26(3):361-8 17500623
Cites Pharmacogenomics J. 2007 Aug;7(4):266-74 17189962
Cites Am J Psychiatry. 2007 Aug;164(8):1181-8 17671280
Cites Nicotine Tob Res. 2007 Dec;9(12):1251-7 18058343
Cites Psychiatr Genet. 2008 Feb;18(1):11-6 18197080
Cites Hum Genet. 2008 Mar;123(2):119-31 18205015
Cites Pharmacogenomics J. 2008 Jun;8(3):209-19 17549066
Cites Am J Med Genet B Neuropsychiatr Genet. 2008 Sep 5;147B(6):712-9 18165968
Cites Am J Public Health. 2000 Jul;90(7):1122-7 10897192
GRANTS
GRANTID AGENCY COUNTRY
089061 Wellcome Trust United Kingdom
AA07580 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
AA13320 NIAAA NIH HHS United States
AA13321 NIAAA NIH HHS United States
DA019951 NIDA NIH HHS United States
DA12854 NIDA NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
K08 DA019951 NIDA NIH HHS United States
K08 DA019951-04 NIDA NIH HHS United States
P50 AA011998 NIAAA NIH HHS United States
P50 AA011998-10 NIAAA NIH HHS United States
R01 AA013320 NIAAA NIH HHS United States
R01 AA013320-05 NIAAA NIH HHS United States
R01 AA013321 NIAAA NIH HHS United States
R01 AA013321-05 NIAAA NIH HHS United States
R01 DA012854 NIDA NIH HHS United States
R01 DA012854-06A2 NIDA NIH HHS United States
R37 AA007728 NIAAA NIH HHS United States
R37 AA007728-20 NIAAA NIH HHS United States
T32 AA007580 NIAAA NIH HHS United States
T32 AA007580-09 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Chromosomes, Human, Pair 11
Diagnostic and Statistical Manual of Mental Disorders
European Continental Ancestry Group genetics
Female genetics
Genetic Linkage genetics
Humans genetics
Male genetics
Oceanic Ancestry Group genetics
Phenotype genetics
Prevalence genetics
Siblings genetics
Smoking genetics
Substance Withdrawal Syndrome genetics
Time Factors genetics
Tobacco Use Disorder genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS253362 NLM
PMC2995916 NLM