Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
19180564
TITLE
Genetic linkage findings for DSM-IV nicotine withdrawal in two populations.
ABSTRACT
Nicotine withdrawal (NW) is both an important contributor to difficulty quitting cigarettes and because of mood-related withdrawal symptoms a problem of particular relevance to psychiatry. Twin-studies suggest that genetic factors influence NW (heritability = 45%). Only one previous linkage study has published findings on NW [Swan et al. (2006); Am J Med Genet Part B 141B:354-360; LOD = 2.7; Chr. 6 at 159 cM]. As part of an international consortium, genome-wide scans (using over 360 autosomal microsatellite markers) and telephone diagnostic interviews were conducted on 289 Australian (AUS) and 161 Finnish (FIN, combined (COMB) N = 450 families) families ascertained from twin registries through index-cases with a lifetime history of cigarette smoking. The statistical approach used an affected-sib-pair design (at least two adult full siblings reported a history of DSM-IV NW) and conducted the linkage analyses using MERLIN. Linkage signals with LOD scores >1.5 were found on two chromosomes: 6 (FIN: LOD = 1.93 at 75 cM) and 11 at two different locations (FIN: LOD = 3.55 at 17 cM, and AUS: LOD = 1.68 with a COMB: LOD = 2.30 at 123 cM). The multipoint LOD score of 3.55 on chromosome 11p15 in FIN met genomewide significance (P = 0.013 with 1,000 simulations). At least four strong candidate genes lie within or near this peak on chromosome 11: DRD4, TPH, TH, and CHRNA10. Other studies have reported that chromosome 11 may harbor genes associated with various aspects of smoking behavior. This study adds to that literature by highlighting evidence for NW.
(c) 2009 Wiley-Liss, Inc.
DATE PUBLISHED
2009 Oct 5
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2009/01/31 09:00
pubmed 2009/01/31 09:00
medline 2009/12/29 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Pergadia ML Pergadia Michele L ML Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri 63110, USA. pergadim@psychiatry.wustl.edu
Agrawal A Agrawal Arpana A
Loukola A Loukola Anu A
Montgomery GW Montgomery Grant W GW
Broms U Broms Ulla U
Saccone SF Saccone Scott F SF
Wang JC Wang Jen C JC
Todorov AA Todorov Alexandre A AA
Heikkilä K Heikkilä Kauko K
Statham DJ Statham Dixie J DJ
Henders AK Henders Anjali K AK
Campbell MJ Campbell Megan J MJ
Rice JP Rice John P JP
Todd RD Todd Richard D RD
Heath AC Heath Andrew C AC
Goate AM Goate Alison M AM
Peltonen L Peltonen Leena L
Kaprio J Kaprio Jaakko J
Martin NG Martin Nicholas G NG
Madden PA Madden Pamela A F PA
INVESTIGATORS
JOURNAL
VOLUME: 150B
ISSUE: 7
TITLE: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
ISOABBREVIATION: Am. J. Med. Genet. B Neuropsychiatr. Genet.
YEAR: 2009
MONTH: Oct
DAY: 5
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1552-485X
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Am J Med Genet B Neuropsychiatr Genet
COUNTRY: United States
ISSNLINKING: 1552-4841
NLMUNIQUEID: 101235742
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
089061 Wellcome Trust United Kingdom
AA07580 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
AA13320 NIAAA NIH HHS United States
AA13321 NIAAA NIH HHS United States
DA019951 NIDA NIH HHS United States
DA12854 NIDA NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
K08 DA019951 NIDA NIH HHS United States
K08 DA019951-04 NIDA NIH HHS United States
P50 AA011998 NIAAA NIH HHS United States
P50 AA011998-10 NIAAA NIH HHS United States
R01 AA013320 NIAAA NIH HHS United States
R01 AA013320-05 NIAAA NIH HHS United States
R01 AA013321 NIAAA NIH HHS United States
R01 AA013321-05 NIAAA NIH HHS United States
R01 DA012854 NIDA NIH HHS United States
R01 DA012854-06A2 NIDA NIH HHS United States
R37 AA007728 NIAAA NIH HHS United States
R37 AA007728-20 NIAAA NIH HHS United States
T32 AA007580 NIAAA NIH HHS United States
T32 AA007580-09 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Chromosomes, Human, Pair 11
Diagnostic and Statistical Manual of Mental Disorders
European Continental Ancestry Group genetics
Female genetics
Genetic Linkage genetics
Humans genetics
Male genetics
Oceanic Ancestry Group genetics
Phenotype genetics
Prevalence genetics
Siblings genetics
Smoking genetics
Substance Withdrawal Syndrome genetics
Time Factors genetics
Tobacco Use Disorder genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS253362 NLM
PMC2995916 NLM
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