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PMID |
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TITLE |
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A quantitative genetic analysis of intermediate asthma phenotypes. |
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ABSTRACT |
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AIM |
NlmCategory: OBJECTIVE |
To study the relative contribution of genetic and environmental factors to the correlation between exhaled nitric oxide (FeNO), airway responsiveness, airway obstruction, and serum total immunoglobulin E (IgE). |
METHODS |
NlmCategory: METHODS |
Within a sampling frame of 21,162 twin subjects, 20-49 years of age, from the Danish Twin Registry, a total of 575 subjects (256 intact pairs and 63 single twins) who either themselves and/or their co-twins reported a history of asthma at a nationwide questionnaire survey, were clinically examined. Traits were measured using standard techniques. Latent factor models were fitted to the observed data using maximum likelihood methods. |
RESULTS |
NlmCategory: RESULTS |
Additive genetic factors explained 67% of the variation in FeNO, 43% in airway responsiveness, 22% in airway obstruction, and 81% in serum total IgE. In general, traits had genetically and environmentally distinct variance structures. The most substantial genetic similarity was observed between FeNO and serum total IgE, genetic correlation (rhoA) = 0.37, whereas the strongest environmental resemblance was observed between airway responsiveness and airway obstruction, specific environmental correlation (rhoE) = -0.46, and between FeNO and airway responsiveness, rhoE = 0.34. |
CONCLUSIONS |
NlmCategory: CONCLUSIONS |
Asthma is a complex disease characterized by a set of etiologically heterogeneous biomarkers, which likely constitute diverse targets of intervention. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
aheadofprint |
2009/01/27 |
entrez |
2009/01/30 09:00 |
pubmed |
2009/01/30 09:00 |
medline |
2009/05/27 09:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Thomsen SF |
|
Thomsen |
S F |
SF |
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Department of Respiratory Medicine, Bispebjerg Hospital, Copenhagen, Denmark. |
Ferreira MA |
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Ferreira |
M A R |
MA |
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Kyvik KO |
|
Kyvik |
K O |
KO |
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Fenger M |
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Fenger |
M |
M |
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Backer V |
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Backer |
V |
V |
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INVESTIGATORS |
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JOURNAL |
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VOLUME: 64 |
ISSUE: 3 |
TITLE: Allergy |
ISOABBREVIATION: Allergy |
YEAR: 2009 |
MONTH: Mar |
DAY: |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 1398-9995 |
ISSNTYPE: Electronic |
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MEDLINE JOURNAL |
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MEDLINETA: Allergy |
COUNTRY: Denmark |
ISSNLINKING: 0105-4538 |
NLMUNIQUEID: 7804028 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
Journal Article |
Twin Study |
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COMMENTS AND CORRECTIONS |
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GRANTS |
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GENERAL NOTE |
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KEYWORDS |
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MESH HEADINGS |
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DESCRIPTORNAME |
QUALIFIERNAME |
Adult |
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Asthma |
physiopathology |
Environmental Exposure |
physiopathology |
Female |
physiopathology |
Humans |
physiopathology |
Immunoglobulin E |
blood |
Male |
blood |
Phenotype |
blood |
Respiratory Function Tests |
blood |
Surveys and Questionnaires |
blood |
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SUPPLEMENTARY MESH |
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GENE SYMBOLS |
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CHEMICALS |
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REGISTRYNUMBER |
NAMEOFSUBSTANCE |
37341-29-0 |
Immunoglobulin E |
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OTHER ID's |
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