Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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GenEpi Intranet
PMID
19175595
TITLE
A quantitative genetic analysis of intermediate asthma phenotypes.
ABSTRACT
AIM NlmCategory: OBJECTIVE
To study the relative contribution of genetic and environmental factors to the correlation between exhaled nitric oxide (FeNO), airway responsiveness, airway obstruction, and serum total immunoglobulin E (IgE).
METHODS NlmCategory: METHODS
Within a sampling frame of 21,162 twin subjects, 20-49 years of age, from the Danish Twin Registry, a total of 575 subjects (256 intact pairs and 63 single twins) who either themselves and/or their co-twins reported a history of asthma at a nationwide questionnaire survey, were clinically examined. Traits were measured using standard techniques. Latent factor models were fitted to the observed data using maximum likelihood methods.
RESULTS NlmCategory: RESULTS
Additive genetic factors explained 67% of the variation in FeNO, 43% in airway responsiveness, 22% in airway obstruction, and 81% in serum total IgE. In general, traits had genetically and environmentally distinct variance structures. The most substantial genetic similarity was observed between FeNO and serum total IgE, genetic correlation (rhoA) = 0.37, whereas the strongest environmental resemblance was observed between airway responsiveness and airway obstruction, specific environmental correlation (rhoE) = -0.46, and between FeNO and airway responsiveness, rhoE = 0.34.
CONCLUSIONS NlmCategory: CONCLUSIONS
Asthma is a complex disease characterized by a set of etiologically heterogeneous biomarkers, which likely constitute diverse targets of intervention.
DATE PUBLISHED
2009 Mar
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2009/01/27
entrez 2009/01/30 09:00
pubmed 2009/01/30 09:00
medline 2009/05/27 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Thomsen SF Thomsen S F SF Department of Respiratory Medicine, Bispebjerg Hospital, Copenhagen, Denmark.
Ferreira MA Ferreira M A R MA
Kyvik KO Kyvik K O KO
Fenger M Fenger M M
Backer V Backer V V
INVESTIGATORS
JOURNAL
VOLUME: 64
ISSUE: 3
TITLE: Allergy
ISOABBREVIATION: Allergy
YEAR: 2009
MONTH: Mar
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1398-9995
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Allergy
COUNTRY: Denmark
ISSNLINKING: 0105-4538
NLMUNIQUEID: 7804028
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Asthma physiopathology
Environmental Exposure physiopathology
Female physiopathology
Humans physiopathology
Immunoglobulin E blood
Male blood
Phenotype blood
Respiratory Function Tests blood
Surveys and Questionnaires blood
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
37341-29-0 Immunoglobulin E
OTHER ID's