|
|
| PMID |
|
|
| TITLE |
|
| A quantitative genetic analysis of intermediate asthma phenotypes. |
|
| ABSTRACT |
|
| AIM |
NlmCategory: OBJECTIVE |
| To study the relative contribution of genetic and environmental factors to the correlation between exhaled nitric oxide (FeNO), airway responsiveness, airway obstruction, and serum total immunoglobulin E (IgE). |
| METHODS |
NlmCategory: METHODS |
| Within a sampling frame of 21,162 twin subjects, 20-49 years of age, from the Danish Twin Registry, a total of 575 subjects (256 intact pairs and 63 single twins) who either themselves and/or their co-twins reported a history of asthma at a nationwide questionnaire survey, were clinically examined. Traits were measured using standard techniques. Latent factor models were fitted to the observed data using maximum likelihood methods. |
| RESULTS |
NlmCategory: RESULTS |
| Additive genetic factors explained 67% of the variation in FeNO, 43% in airway responsiveness, 22% in airway obstruction, and 81% in serum total IgE. In general, traits had genetically and environmentally distinct variance structures. The most substantial genetic similarity was observed between FeNO and serum total IgE, genetic correlation (rhoA) = 0.37, whereas the strongest environmental resemblance was observed between airway responsiveness and airway obstruction, specific environmental correlation (rhoE) = -0.46, and between FeNO and airway responsiveness, rhoE = 0.34. |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| Asthma is a complex disease characterized by a set of etiologically heterogeneous biomarkers, which likely constitute diverse targets of intervention. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| aheadofprint |
2009/01/27 |
| entrez |
2009/01/30 09:00 |
| pubmed |
2009/01/30 09:00 |
| medline |
2009/05/27 09:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Thomsen SF |
|
Thomsen |
S F |
SF |
|
Department of Respiratory Medicine, Bispebjerg Hospital, Copenhagen, Denmark. |
| Ferreira MA |
|
Ferreira |
M A R |
MA |
|
|
| Kyvik KO |
|
Kyvik |
K O |
KO |
|
|
| Fenger M |
|
Fenger |
M |
M |
|
|
| Backer V |
|
Backer |
V |
V |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 64 |
| ISSUE: 3 |
| TITLE: Allergy |
| ISOABBREVIATION: Allergy |
| YEAR: 2009 |
| MONTH: Mar |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1398-9995 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Allergy |
| COUNTRY: Denmark |
| ISSNLINKING: 0105-4538 |
| NLMUNIQUEID: 7804028 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Asthma |
physiopathology |
| Environmental Exposure |
physiopathology |
| Female |
physiopathology |
| Humans |
physiopathology |
| Immunoglobulin E |
blood |
| Male |
blood |
| Phenotype |
blood |
| Respiratory Function Tests |
blood |
| Surveys and Questionnaires |
blood |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 37341-29-0 |
Immunoglobulin E |
|
| OTHER ID's |
|
|
|
