Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
19129088
TITLE
The role of aldehyde dehydrogenase-1 (ALDH1A1) polymorphisms in harmful alcohol consumption in a Finnish population.
ABSTRACT
Liver cystolic aldehyde dehydrogenase 1 (ALDH1A1) has been previously associated with both alcohol dependence and alcohol consumption behaviour, and has been implicated in alcohol-induced flushing and alcohol sensitivity in Caucasians. The present study tested for association between ALDH1A1 and alcohol consumption behaviour and susceptibility to problem drinking or alcohol dependence in Finnish cohorts of unrelated male subjects recruited from alcoholism clinical treatment facilities ( n = 104) and from the general population ( n = 201). All participants completed the Alcohol Use Disorder Identification Test (AUDIT) and were genotyped for eight single nucleotide polymorphisms (SNPs) within or flanking ALDH1A1 . To test for association between alcohol consumption behaviour and these polymorphisms, we used generalised linear models and haplotypic analysis. Three SNPs were nominally associated (rs348449, p = 0.043; rs610529, p = 0.013; rs348479, p = 0.025) with the quantitative AUDIT score, which evaluates alcohol consumption behaviour. Two-locus (rs610529-rs2288087) haplotype analysis increased the strength of association with AUDIT score ( p = 0.0015). Additionally, rs348449 is highly associated with problem drinking (allelic odds ratio [OR] 7.87, 95 per cent confidence interval [CI] 1.67-37.01) but due to the low minor allele frequency (0.01 and 0.07 in controls and problem drinkers, respectively), more samples are required to validate this observation. Conversely, rs348479 ( p = 0.019) and rs610529 (allelic OR 0.65, 95 per cent CI 0.43-0.98; genotypic OR 0.32, 95 per cent CI 0.12-0.84) are implicated in alcohol dependence status. This study provides further evidence for a role for ALDH1A1 in alcohol consumption behaviour, including problem drinking and possibly alcohol dependence, in our Finnish population.
DATE PUBLISHED
2008 Sep
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2009/01/09 09:00
pubmed 2009/01/09 09:00
medline 2009/04/03 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Lind PA Lind Penelope A PA Department of Genetic Epidemiology, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, QLD 4029, Australia.
Eriksson CJ Eriksson C J Peter CJ
Wilhelmsen KC Wilhelmsen Kirk C KC
INVESTIGATORS
JOURNAL
VOLUME: 3
ISSUE: 1
TITLE: Human genomics
ISOABBREVIATION: Hum. Genomics
YEAR: 2008
MONTH: Sep
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1479-7364
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Hum Genomics
COUNTRY: England
ISSNLINKING: 1473-9542
NLMUNIQUEID: 101202210
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Aged
Alcohol Drinking therapy
Aldehyde Dehydrogenase genetics
Alleles genetics
Case-Control Studies genetics
Cytosol enzymology
European Continental Ancestry Group genetics
Finland genetics
Genetic Predisposition to Disease genetics
Haplotypes genetics
Humans genetics
Linkage Disequilibrium genetics
Male genetics
Middle Aged genetics
Polymorphism, Single Nucleotide genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
EC 1.2.1.3 ALDH1A1 protein, human
EC 1.2.1.3 Aldehyde Dehydrogenase
OTHER ID's
OTHERID SOURCE
PMC3525184 NLM