Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
19077176
TITLE
Variation in the dysbindin gene and normal cognitive function in three independent population samples.
ABSTRACT
The association between DTNBP1 genotype and cognitive abilities was investigated in three population samples (1054 Scottish, 1806 Australian and 745 English) of varying age. There was evidence in each of the cohorts for association (P < 0.05) to single nucleotide polymorphisms (SNPs) and haplotypes previously shown to relate to cognition. By comparison with previous findings, these associations included measures of memory, and there was at best equivocal evidence of association with general cognitive ability. Of the SNPs typed in all three cohorts, rs2619528 and rs1011313 showed significant association with measures of executive function in two cohorts, rs1018381 showed significant association with verbal ability in one cohort and rs2619522 showed significance/marginal significance with tests of memory, speed and executive function in two cohorts. For all these SNPs, the direction and magnitude of the allelic effects were consistent between cohorts and with previous findings. In the English cohort, a previously untested SNP (rs742105) located in a distinct haplotype block upstream of the other SNPs showed the strongest significance (P < 0.01) for measures of memory but weaker significance for general cognitive ability. Our results therefore support involvement of the dysbindin gene in cognitive function, but further work is needed to clarify the specific functional variants involved and the cognitive abilities with which they are associated.
DATE PUBLISHED
2009 Mar
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2008/12/03
entrez 2008/12/17 09:00
pubmed 2008/12/17 09:00
medline 2009/06/27 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Luciano M Luciano M M Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK. michelle.luciano@ed.ac.uk
Miyajima F Miyajima F F
Lind PA Lind P A PA
Bates TC Bates T C TC
Horan M Horan M M
Harris SE Harris S E SE
Wright MJ Wright M J MJ
Ollier WE Ollier W E WE
Hayward C Hayward C C
Pendleton N Pendleton N N
Gow AJ Gow A J AJ
Visscher PM Visscher P M PM
Starr JM Starr J M JM
Deary IJ Deary I J IJ
Martin NG Martin N G NG
Payton A Payton A A
INVESTIGATORS
JOURNAL
VOLUME: 8
ISSUE: 2
TITLE: Genes, brain, and behavior
ISOABBREVIATION: Genes Brain Behav.
YEAR: 2009
MONTH: Mar
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1601-183X
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Genes Brain Behav
COUNTRY: England
ISSNLINKING: 1601-183X
NLMUNIQUEID: 101129617
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
G0700704B Medical Research Council United Kingdom
MC_PC_U127561128 Medical Research Council United Kingdom
Biotechnology and Biological Sciences Research Council United Kingdom
Medical Research Council United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Aged
Alleles
Australia
Carrier Proteins genetics
Cognition physiology
Cohort Studies physiology
England physiology
Female physiology
Gene Frequency physiology
Genetic Variation physiology
Genotype physiology
Haplotypes physiology
Humans physiology
Linkage Disequilibrium physiology
Male physiology
Memory physiology
Neuropsychological Tests physiology
Polymorphism, Single Nucleotide physiology
Population physiology
Psychomotor Performance physiology
Scotland physiology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Carrier Proteins
0 DTNBP1 protein, human
OTHER ID's