Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
About GenEpi
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
19041405
TITLE
Mapping genetic influences on ventricular structure in twins.
ABSTRACT
Despite substantial progress in measuring the anatomical and functional variability of the human brain, little is known about the genetic and environmental causes of these variations. Here we developed an automated system to visualize genetic and environmental effects on brain structure in large brain MRI databases. We applied our multi-template segmentation approach termed "Multi-Atlas Fluid Image Alignment" to fluidly propagate hand-labeled parameterized surface meshes, labeling the lateral ventricles, in 3D volumetric MRI scans of 76 identical (monozygotic, MZ) twins (38 pairs; mean age=24.6 (SD=1.7)); and 56 same-sex fraternal (dizygotic, DZ) twins (28 pairs; mean age=23.0 (SD=1.8)), scanned as part of a 5-year research study that will eventually study over 1000 subjects. Mesh surfaces were averaged within subjects to minimize segmentation error. We fitted quantitative genetic models at each of 30,000 surface points to measure the proportion of shape variance attributable to (1) genetic differences among subjects, (2) environmental influences unique to each individual, and (3) shared environmental effects. Surface-based statistical maps, derived from path analysis, revealed patterns of heritability, and their significance, in 3D. Path coefficients for the 'ACE' model that best fitted the data indicated significant contributions from genetic factors (A=7.3%), common environment (C=38.9%) and unique environment (E=53.8%) to lateral ventricular volume. Earlier-maturing occipital horn regions may also be more genetically influenced than later-maturing frontal regions. Maps visualized spatially-varying profiles of environmental versus genetic influences. The approach shows promise for automatically measuring gene-environment effects in large image databases.
DATE PUBLISHED
2009 Feb 15
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2008/04/12
revised 2008/10/15
accepted 2008/10/21
aheadofprint 2008/11/07
pubmed 2008/12/02 09:00
medline 2009/03/27 09:00
entrez 2008/12/02 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Chou YY Chou Yi-Yu YY Department of Neurology, UCLA School of Medicine, Laboratory of Neuro Imaging, Los Angeles, CA 90095-7332, USA.
Leporé N Leporé Natasha N
Chiang MC Chiang Ming-Chang MC
Avedissian C Avedissian Christina C
Barysheva M Barysheva Marina M
McMahon KL McMahon Katie L KL
de Zubicaray GI de Zubicaray Greig I GI
Meredith M Meredith Matthew M
Wright MJ Wright Margaret J MJ
Toga AW Toga Arthur W AW
Thompson PM Thompson Paul M PM
INVESTIGATORS
JOURNAL
VOLUME: 44
ISSUE: 4
TITLE: NeuroImage
ISOABBREVIATION: Neuroimage
YEAR: 2009
MONTH: Feb
DAY: 15
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1095-9572
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Neuroimage
COUNTRY: United States
ISSNLINKING: 1053-8119
NLMUNIQUEID: 9215515
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Am J Med Genet B Neuropsychiatr Genet. 2009 Jul 5;150B(5):683-92 19051289
Cites Hum Brain Mapp. 2009 Sep;30(9):2766-88 19172649
Cites Nature. 2000 Mar 9;404(6774):190-3 10724172
Cites Neurobiol Aging. 2000 Jan-Feb;21(1):63-74 10794850
Cites Behav Genet. 2000 Jul;30(4):311-9 11206086
Cites Neuroreport. 2001 Jun 13;12(8):1677-81 11409738
Cites Biol Psychiatry. 2001 Jul 15;50(2):84-97 11526999
Cites Cereb Cortex. 2001 Sep;11(9):816-24 11532887
Cites Philos Trans R Soc Lond B Biol Sci. 2001 Aug 29;356(1412):1293-322 11545704
Cites Nat Neurosci. 2001 Dec;4(12):1253-8 11694885
Cites Hippocampus. 2001;11(6):754-62 11811670
Cites Nat Neurosci. 2002 Feb;5(2):83-4 11818967
Cites Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3228-33 11867725
Cites Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3176-81 11867730
Cites Cereb Cortex. 2002 May;12(5):486-93 11950766
Cites Neuroimage. 2002 Sep;17(1):256-71 12482082
Cites Ann Med. 2002;34(7-8):523-36 12553492
Cites Neurosci Lett. 2003 Feb 27;338(2):91-4 12566160
Cites Nat Neurosci. 2003 Mar;6(3):309-15 12548289
Cites Neuroimage. 2003 Aug;19(4):1829-34 12948737
Cites Neurobiol Aging. 2004 Feb;25(2):175-83 14749135
Cites Nat Rev Neurosci. 2004 Jun;5(6):471-82 15152197
Cites Proc Natl Acad Sci U S A. 2004 May 25;101(21):8174-9 15148381
Cites J Neurosci. 2004 Jun 30;24(26):6028-36 15229250
Cites Neuroimage. 2004 Aug;22(4):1754-66 15275931
Cites J Lipid Res. 1982 Aug;23(6):911-4 7130859
Cites Ann Neurol. 1989 Jul;26(1):100-4 2774498
Cites Science. 1993 Aug 13;261(5123):921-3 8346443
Cites J Comput Assist Tomogr. 1994 Mar-Apr;18(2):192-205 8126267
Cites Behav Genet. 1994 May;24(3):207-15 7945151
Cites Cereb Cortex. 1996 Jul-Aug;6(4):551-60 8670681
Cites Arch Ophthalmol. 1997 May;115(5):659-63 9152135
Cites Neuroimage. 1996 Feb;3(1):19-34 9345472
Cites Ann N Y Acad Sci. 1998 Nov 30;855:738-43 9929679
Cites Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4872-7 15772166
Cites Br J Educ Psychol. 2005 Sep;75(Pt 3):339-50 16238870
Cites Arch Gen Psychiatry. 2005 Nov;62(11):1205-13 16275808
Cites Arch Gen Psychiatry. 2006 Jan;63(1):25-34 16389194
Cites Neuroimage. 2006 May 15;31(1):12-23 16427319
Cites J Neurosci. 2006 Oct 4;26(40):10235-42 17021179
Cites J Child Psychol Psychiatry. 2006 Oct;47(10):987-93 17073977
Cites Neuroimage. 2007 Feb 1;34(3):924-38 17161622
Cites Alzheimer Dis Assoc Disord. 2007 Jan-Mar;21(1):14-24 17334268
Cites Hum Brain Mapp. 2007 Jun;28(6):519-32 17437284
Cites Hum Brain Mapp. 2007 Jun;28(6):474-81 17437295
Cites Hum Brain Mapp. 2007 Jun;28(6):488-501 17440953
Cites Hum Brain Mapp. 2007 Jun;28(6):461-3 17471577
Cites Lancet Neurol. 2007 Jun;6(6):494-500 17509484
Cites Arch Neurol. 2007 Jun;64(6):862-71 17562935
Cites Cereb Cortex. 2007 Aug;17(8):1889-98 17056649
Cites Neurobiol Aging. 2007 Sep;28(9):1316-21 16875759
Cites Twin Res Hum Genet. 2007 Oct;10(5):683-94 17903108
Cites Ann Neurol. 2008 Jan;63(1):40-51 17932962
Cites Neurology. 2008 Mar 11;70(11):824-5 18332339
Cites Neuroimage. 2008 Apr 1;40(2):615-30 18222096
Cites Psychiatry Res. 2008 Jul 15;163(2):106-15 18502618
Cites Neuroimage. 2008 Jul 15;41(4):1177-83 18486492
Cites Cereb Cortex. 2008 Aug;18(8):1737-47 18234689
Cites Biol Psychol. 2008 Sep;79(1):70-9 18423837
Cites Psychol Bull. 1979 Mar;86(2):420-8 18839484
Cites Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15979-84 18852461
Cites Neuroimage. 2008 Nov 15;43(3):458-69 18691658
Cites Hum Brain Mapp. 2009 Jan;30(1):163-74 18041741
Cites Hum Brain Mapp. 2009 Jan;30(1):209-19 18064588
Cites Neuroimage. 2009 Aug 1;47(1):56-64 18672072
GRANTS
GRANTID AGENCY COUNTRY
R01 HD050735 NICHD NIH HHS United States
R01 HD050735 NICHD NIH HHS United States
R01 HD050735-02 NICHD NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Cerebral Ventricles anatomy & histology
Female anatomy & histology
Humans anatomy & histology
Magnetic Resonance Imaging methods
Male methods
Pilot Projects methods
Reproducibility of Results methods
Sensitivity and Specificity methods
Twins genetics
Young Adult genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS133683 NLM
PMC2773138 NLM
Designed by: GenEpi IT
Maintained by: GenEpi IT
Feedback: webmaster
Copyright © 2007 QIMR
For more information Contact Us
epiit@qimr.edu.au
Last Modified: Oct 15 2007