Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
About GenEpi
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
19032539
TITLE
Early cannabis use and DSM-IV nicotine dependence: a twin study.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Evidence suggests that cannabis users are at increased risk for cigarette smoking--if so, this may potentially be the single most alarming public health challenge posed by cannabis use. We examine whether cannabis use prior to age 17 years is associated with an increased likelihood of DSM-IV nicotine dependence and the extent to which genetic and environmental factors contribute to this association.
METHODS NlmCategory: METHODS
A population-based cohort of 24-36-year-old Australian male and female twins (n=6257, 286 and 229 discordant pairs) was used. The co-twin-control method, with twin pairs discordant for early cannabis use, was used to examine whether, after controlling for genetic and familial environmental background, there was evidence for an additional influence of early cannabis use on DSM-IV nicotine dependence. Bivariate genetic models were fitted to the full data set to quantify the genetic correlation between early cannabis use and nicotine dependence.
RESULTS NlmCategory: RESULTS
The early cannabis-using twin was about twice as likely to report nicotine dependence, when compared to their co-twin who had experimented with cigarettes but had never used cannabis. Even when analyses were restricted to cannabis users, earlier age cannabis use onset conferred greater risk (1.7) for nicotine dependence than did later onset. This association was governed largely by common genetic liability to early cannabis use and nicotine dependence, as demonstrated by genetic correlations of 0.41-0.52.
CONCLUSIONS NlmCategory: CONCLUSIONS
Early-onset cannabis users are at increased risk for nicotine dependence, but this risk is attributable largely to common genetic vulnerability. There is no evidence for a causal relationship between cannabis use and nicotine dependence.
DATE PUBLISHED
2008 Nov
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2008/11/27 09:00
medline 2009/02/10 09:00
entrez 2008/11/27 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Agrawal A Agrawal Arpana A Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63110, USA. arpana@wustl.edu
Lynskey MT Lynskey Michael T MT
Pergadia ML Pergadia Michele L ML
Bucholz KK Bucholz Kathleen K KK
Heath AC Heath Andrew C AC
Martin NG Martin Nicholas G NG
Madden PA Madden Pamela A F PA
INVESTIGATORS
JOURNAL
VOLUME: 103
ISSUE: 11
TITLE: Addiction (Abingdon, England)
ISOABBREVIATION: Addiction
YEAR: 2008
MONTH: Nov
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1360-0443
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Addiction
COUNTRY: England
ISSNLINKING: 0965-2140
NLMUNIQUEID: 9304118
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Drug Alcohol Depend. 2008 May 1;95(1-2):107-14 18325694
Cites Drug Alcohol Depend. 2008 Jun 1;95(3):199-208 18339491
Cites Psychiatr Genet. 2006 Feb;16(1):9-17 16395124
Cites J Abnorm Psychol. 2006 Feb;115(1):26-39 16492093
Cites Expert Opin Investig Drugs. 2006 Mar;15(3):307-15 16503766
Cites Handb Exp Pharmacol. 2005;(168):691-717 16596793
Cites Behav Genet. 2006 Mar;36(2):195-200 16402286
Cites Addiction. 2006 Jun;101(6):801-12 16696624
Cites Psychol Med. 2006 Jul;36(7):963-72 16749946
Cites Am J Med Genet B Neuropsychiatr Genet. 2006 Jul 5;141B(5):499-503 16741937
Cites Behav Genet. 2006 Jul;36(4):567-76 16477519
Cites Behav Genet. 2006 Jul;36(4):577-90 16557364
Cites Behav Genet. 2006 Jul;36(4):498-506 16565887
Cites Behav Genet. 2006 Jul;36(4):603-15 16619135
Cites Behav Genet. 2006 Jul;36(4):507-24 16770695
Cites J Adolesc Health. 2006 Aug;39(2):214-20 16857533
Cites Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141B(8):895-901 16917946
Cites Dev Psychopathol. 1999 Fall;11(4):869-900 10624730
Cites Addiction. 1999 Jul;94(7):981-93 10707437
Cites Behav Genet. 1999 Nov;29(6):423-31 10857247
Cites Jpn J Pharmacol. 2000 Nov;84(3):229-36 11138722
Cites Twin Res. 2001 Apr;4(2):73-80 11665339
Cites Nicotine Tob Res. 1999;1 Suppl 2:S51-7; discussion S69-70 11768187
Cites Arch Gen Psychiatry. 2002 Feb;59(2):139-45 11825135
Cites J Abnorm Psychol. 2002 Aug;111(3):411-24 12150417
Cites Neuropharmacology. 2002 Oct;43(5):857-67 12384171
Cites Arch Gen Psychiatry. 2002 Dec;59(12):1125-32 12470129
Cites JAMA. 2003 Jan 22-29;289(4):427-33 12533121
Cites Arch Gen Psychiatry. 2003 Sep;60(9):929-37 12963675
Cites Addiction. 2003 Nov;98(11):1493-504 14616175
Cites Addiction. 2004 Jan;99(1):77-81 14678065
Cites Biol Psychiatry. 2004 Jan 1;55(1):69-76 14706427
Cites Am J Hum Genet. 2004 Apr;74(4):705-14 15024690
Cites Am J Med Genet B Neuropsychiatr Genet. 2004 Aug 15;129B(1):104-9 15274050
Cites J Abnorm Psychol. 2004 Aug;113(3):440-50 15311989
Cites Mol Psychiatry. 2004 Oct;9(10):916-31 15289816
Cites Addiction. 2008 Jun;103(6):1027-38 18482426
Cites Nicotine Tob Res. 2006 Apr;8(2):257-62 16766418
Cites Science. 1992 Dec 18;258(5090):1946-9 1470919
Cites Arch Gen Psychiatry. 1993 Jan;50(1):36-43 8422220
Cites MMWR Morb Mortal Wkly Rep. 1993 Apr 2;42(12):230-3 8450828
Cites J Stud Alcohol. 1994 Mar;55(2):149-58 8189735
Cites Child Abuse Negl. 1997 Jun;21(6):529-39 9192142
Cites Proc Natl Acad Sci U S A. 1999 May 11;96(10):5780-5 10318961
Cites Psychol Med. 2004 Oct;34(7):1227-37 15697049
Cites Nicotine Tob Res. 2004 Dec;6(6):1029-38 15801576
Cites Alcohol Clin Exp Res. 2005 Apr;29(4):493-8 15834213
Cites Am J Prev Med. 2005 Jun;28(5):430-8 15894146
Cites Addiction. 2005 Oct;100(10):1518-25 16185213
Cites Drug Alcohol Rev. 2005 Jan;24(1):39-48 16191720
Cites Arch Gen Psychiatry. 2004 Oct;61(10):1026-32 15466676
Cites Neuroreport. 2004 Sep 15;15(13):2139-43 15486497
Cites Psychol Med. 2004 Jul;34(5):865-79 15500307
Cites J Consult Clin Psychol. 1985 Dec;53(6):890-904 4086689
Cites J Adolesc. 1987 Mar;10(1):13-34 3584593
Cites Acta Genet Med Gemellol (Roma). 1990;39(4):447-58 2102589
Cites Br J Psychiatry. 1991 Nov;159:653-8 1756341
Cites Acta Psychiatr Scand. 1992 Feb;85(2):136-42 1543039
Cites N Engl J Med. 1992 Sep 17;327(12):829-33 1508241
Cites Behav Genet. 2006 Sep;36(5):640-50 16622805
Cites Annu Rev Pharmacol Toxicol. 2007;47:541-64 17209799
Cites Drug Alcohol Depend. 2007 May 11;88(2-3):272-81 17174040
Cites Cochrane Database Syst Rev. 2007;(3):CD005353 17636794
Cites Am J Health Syst Pharm. 2007 Aug 15;64(16):1693-8 17687057
Cites Chem Biodivers. 2007 Aug;4(8):1805-27 17712820
Cites Biol Psychiatry. 2007 Sep 15;62(6):616-26 17509535
GRANTS
GRANTID AGENCY COUNTRY
AA07728 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
AA13221 NIAAA NIH HHS United States
DA019951 NIDA NIH HHS United States
DA023668 NIDA NIH HHS United States
DA12854 NIDA NIH HHS United States
DA18267 NIDA NIH HHS United States
DA18660 NIDA NIH HHS United States
K08 DA019951 NIDA NIH HHS United States
K08 DA019951-04 NIDA NIH HHS United States
P50 AA011998 NIAAA NIH HHS United States
P50 AA011998-10 NIAAA NIH HHS United States
R01 AA013321 NIAAA NIH HHS United States
R01 AA013321-05 NIAAA NIH HHS United States
R01 DA012854 NIDA NIH HHS United States
R01 DA012854-05 NIDA NIH HHS United States
R01 DA018267-04 NIDA NIH HHS United States
R01 DA018660-05 NIDA NIH HHS United States
R01 DA023668 NIDA NIH HHS United States
R01 DA023668-01 NIDA NIH HHS United States
R01 DA023668-02 NIDA NIH HHS United States
R37 AA007728 NIAAA NIH HHS United States
R37 AA007728-20 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Australia epidemiology
Diseases in Twins genetics
Female genetics
Humans genetics
Male genetics
Marijuana Abuse genetics
Mental Disorders genetics
Risk Factors genetics
Smoking genetics
Street Drugs genetics
Substance-Related Disorders genetics
Tobacco Use Disorder genetics
Twins, Dizygotic genetics
Twins, Monozygotic genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Street Drugs
OTHER ID's
OTHERID SOURCE
NIHMS74111 NLM
PMC2596656 NLM
Designed by: GenEpi IT
Maintained by: GenEpi IT
Feedback: webmaster
Copyright © 2007 QIMR
For more information Contact Us
epiit@qimr.edu.au
Last Modified: Oct 15 2007