Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
19030008
TITLE
Replication of the association of common rs9939609 variant of FTO with increased BMI in an Australian adult twin population but no evidence for gene by environment (G x E) interaction.
ABSTRACT
OBJECTIVE NlmCategory: OBJECTIVE
To further investigate a common variant (rs9939609) in the fat mass- and obesity-associated gene (FTO), which recent genome-wide association studies have shown to be associated with body mass index (BMI) and obesity.
DESIGN NlmCategory: METHODS
We examined the effect of this FTO variant on BMI in 3353 Australian adult male and female twins.
RESULTS NlmCategory: RESULTS
The minor A allele of rs9939609 was associated with an increased BMI (P=0.0007). Each additional copy of the A allele was associated with a mean BMI increase of approximately 1.04 kg/m(2) (approximately 3.71 kg). Using variance components decomposition, we estimate that this single-nucleotide polymorphism accounts for approximately 3% of the genetic variance in BMI in our sample (approximately 2% of the total variance). By comparing intrapair variances of monozygotic twins of different genotypes we were able to perform a direct test of gene by environment (G x E) interaction in both sexes and gene by parity (G x P) interaction in women, but no evidence was found for either.
CONCLUSIONS NlmCategory: CONCLUSIONS
In addition to supporting earlier findings that the rs9939609 variant in the FTO gene is associated with an increased BMI, our results indicate that the associated genetic effect does not interact with environment or parity.
DATE PUBLISHED
2009 Jan
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2008/11/25
pubmed 2008/11/26 09:00
medline 2009/09/17 06:00
entrez 2008/11/26 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Cornes BK Cornes B K BK Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia. belinda.cornes@gmail.com
Lind PA Lind P A PA
Medland SE Medland S E SE
Montgomery GW Montgomery G W GW
Nyholt DR Nyholt D R DR
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 33
ISSUE: 1
TITLE: International journal of obesity (2005)
ISOABBREVIATION: Int J Obes (Lond)
YEAR: 2009
MONTH: Jan
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1476-5497
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Int J Obes (Lond)
COUNTRY: England
ISSNLINKING: 0307-0565
NLMUNIQUEID: 101256108
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AA 07535 NIAAA NIH HHS United States
AA 07728 NIAAA NIH HHS United States
AA 10249 NIAAA NIH HHS United States
DA 00272 NIDA NIH HHS United States
DA 07261 NIDA NIH HHS United States
MH 14677 NIMH NIH HHS United States
MH 17104 NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Age Factors
Aged
Aged, 80 and over
Australia
Body Mass Index
Chi-Square Distribution
Europe ethnology
Female ethnology
Gene Expression ethnology
Genetic Predisposition to Disease ethnology
Genotype ethnology
Homozygote ethnology
Humans ethnology
Life Style ethnology
Likelihood Functions ethnology
Male ethnology
Middle Aged ethnology
Obesity genetics
Parity genetics
Polymorphism, Single Nucleotide genetics
Pregnancy genetics
Proteins genetics
Sex Factors genetics
Twins genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 FTO protein, human
0 Proteins
OTHER ID's