|
|
| PMID |
|
|
| TITLE |
|
| Replication of the association of common rs9939609 variant of FTO with increased BMI in an Australian adult twin population but no evidence for gene by environment (G x E) interaction. |
|
| ABSTRACT |
|
| OBJECTIVE |
NlmCategory: OBJECTIVE |
| To further investigate a common variant (rs9939609) in the fat mass- and obesity-associated gene (FTO), which recent genome-wide association studies have shown to be associated with body mass index (BMI) and obesity. |
| DESIGN |
NlmCategory: METHODS |
| We examined the effect of this FTO variant on BMI in 3353 Australian adult male and female twins. |
| RESULTS |
NlmCategory: RESULTS |
| The minor A allele of rs9939609 was associated with an increased BMI (P=0.0007). Each additional copy of the A allele was associated with a mean BMI increase of approximately 1.04 kg/m(2) (approximately 3.71 kg). Using variance components decomposition, we estimate that this single-nucleotide polymorphism accounts for approximately 3% of the genetic variance in BMI in our sample (approximately 2% of the total variance). By comparing intrapair variances of monozygotic twins of different genotypes we were able to perform a direct test of gene by environment (G x E) interaction in both sexes and gene by parity (G x P) interaction in women, but no evidence was found for either. |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| In addition to supporting earlier findings that the rs9939609 variant in the FTO gene is associated with an increased BMI, our results indicate that the associated genetic effect does not interact with environment or parity. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| aheadofprint |
2008/11/25 |
| pubmed |
2008/11/26 09:00 |
| medline |
2009/09/17 06:00 |
| entrez |
2008/11/26 09:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Cornes BK |
|
Cornes |
B K |
BK |
|
Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia. belinda.cornes@gmail.com |
| Lind PA |
|
Lind |
P A |
PA |
|
|
| Medland SE |
|
Medland |
S E |
SE |
|
|
| Montgomery GW |
|
Montgomery |
G W |
GW |
|
|
| Nyholt DR |
|
Nyholt |
D R |
DR |
|
|
| Martin NG |
|
Martin |
N G |
NG |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 33 |
| ISSUE: 1 |
| TITLE: International journal of obesity (2005) |
| ISOABBREVIATION: Int J Obes (Lond) |
| YEAR: 2009 |
| MONTH: Jan |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1476-5497 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Int J Obes (Lond) |
| COUNTRY: England |
| ISSNLINKING: 0307-0565 |
| NLMUNIQUEID: 101256108 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| AA 07535 |
NIAAA NIH HHS |
United States |
| AA 07728 |
NIAAA NIH HHS |
United States |
| AA 10249 |
NIAAA NIH HHS |
United States |
| DA 00272 |
NIDA NIH HHS |
United States |
| DA 07261 |
NIDA NIH HHS |
United States |
| MH 14677 |
NIMH NIH HHS |
United States |
| MH 17104 |
NIMH NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Age Factors |
|
| Aged |
|
| Aged, 80 and over |
|
| Australia |
|
| Body Mass Index |
|
| Chi-Square Distribution |
|
| Europe |
ethnology |
| Female |
ethnology |
| Gene Expression |
ethnology |
| Genetic Predisposition to Disease |
ethnology |
| Genotype |
ethnology |
| Homozygote |
ethnology |
| Humans |
ethnology |
| Life Style |
ethnology |
| Likelihood Functions |
ethnology |
| Male |
ethnology |
| Middle Aged |
ethnology |
| Obesity |
genetics |
| Parity |
genetics |
| Polymorphism, Single Nucleotide |
genetics |
| Pregnancy |
genetics |
| Proteins |
genetics |
| Sex Factors |
genetics |
| Twins |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
FTO protein, human |
| 0 |
Proteins |
|
| OTHER ID's |
|
|
|
