Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
19016887
TITLE
Shared aetiology of risky sexual behaviour and adolescent misconduct: genetic and environmental influences.
ABSTRACT
Risky sexual behaviour (RSB) is a major risk factor for serious diseases as well as unplanned pregnancy. It is not known if RSB has a genetic basis or if it is only influenced by social and cultural conditions. Adolescent conduct disorder has previously been linked to RSB and has been found to be influenced by both genetic and environmental factors. In this study, we look at normal variation in a broad measure of RSB and in retrospectively reported adolescent misconduct in a large community sample of twins (n = 4904) to partition the variance and covariance between the traits into genetic and environmental components. We found that RSB is influenced to the same extent by genes, shared environment and unshared environment. Adolescent misconduct is moderately influenced by genetic factors and only modestly by shared environmental factors. Moreover, RSB is associated with adolescent misconduct (r = 0.5), primarily because of genetic correlation between the variables. The implications of our findings as well as possible sex differences are discussed.
DATE PUBLISHED
2009 Feb
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2008/11/20 09:00
medline 2009/05/12 09:00
entrez 2008/11/20 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Verweij KJ Verweij K J H KJ Genetic Epidemiology, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, QLD 4029, Australia. karin.verweij@qimr.edu.au
Zietsch BP Zietsch B P BP
Bailey JM Bailey J M JM
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 8
ISSUE: 1
TITLE: Genes, brain, and behavior
ISOABBREVIATION: Genes Brain Behav.
YEAR: 2009
MONTH: Feb
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1601-183X
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Genes Brain Behav
COUNTRY: England
ISSNLINKING: 1601-183X
NLMUNIQUEID: 101129617
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
R03 MH NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Conduct Disorder psychology
Data Interpretation, Statistical psychology
Environment psychology
Female psychology
Humans psychology
Male psychology
Middle Aged psychology
Models, Genetic psychology
Questionnaires psychology
Unsafe Sex statistics & numerical data
Young Adult statistics & numerical data
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's