PMID |
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TITLE |
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A tensor-based morphometry study of genetic influences on brain structure using a new fluid registration method. |
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ABSTRACT |
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We incorporated a new Riemannian fluid registration algorithm into a general MRI analysis method called tensor-based morphometry to map the heritability of brain morphology in MR images from 23 monozygotic and 23 dizygotic twin pairs. All 92 3D scans were fluidly registered to a common template. Voxelwise Jacobian determinants were computed from the deformation fields to assess local volumetric differences across subjects. Heritability maps were computed from the intraclass correlations and their significance was assessed using voxelwise permutation tests. Lobar volume heritability was also studied using the ACE genetic model. The performance of this Riemannian algorithm was compared to a more standard fluid registration algorithm: 3D maps from both registration techniques displayed similar heritability patterns throughout the brain. Power improvements were quantified by comparing the cumulative distribution functions of the p-values generated from both competing methods. The Riemannian algorithm outperformed the standard fluid registration. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
pubmed |
2008/11/06 09:00 |
medline |
2008/12/31 09:00 |
entrez |
2008/11/06 09:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Brun C |
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Brun |
Caroline |
C |
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Laboratory of Neuro Imaging, UCLA, Los Angeles, CA 90095, USA. |
Leporé N |
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Leporé |
Natasha |
N |
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Pennec X |
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Pennec |
Xavier |
X |
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Chou YY |
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Chou |
Yi-Yu |
YY |
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Lee AD |
|
Lee |
Agatha D |
AD |
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Barysheva M |
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Barysheva |
Marina |
M |
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de Zubicaray G |
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de Zubicaray |
Grieg |
G |
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Meredith M |
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Meredith |
Matthew |
M |
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McMahon K |
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McMahon |
Katie |
K |
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Wright MJ |
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Wright |
Margaret J |
MJ |
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Toga AW |
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Toga |
Arthur W |
AW |
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Thompson PM |
|
Thompson |
Paul M |
PM |
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INVESTIGATORS |
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JOURNAL |
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VOLUME: 11 |
ISSUE: Pt 2 |
TITLE: Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention |
ISOABBREVIATION: Med Image Comput Comput Assist Interv |
YEAR: 2008 |
MONTH: |
DAY: |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Print |
ISSN: |
ISSNTYPE: |
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MEDLINE JOURNAL |
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MEDLINETA: Med Image Comput Comput Assist Interv |
COUNTRY: Germany |
ISSNLINKING: 1433-7851 |
NLMUNIQUEID: 101249582 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
Journal Article |
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COMMENTS AND CORRECTIONS |
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REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
Cites |
Nature. 2000 Mar 9;404(6774):190-3 |
10724172 |
|
Cites |
Psychol Bull. 1979 Mar;86(2):420-8 |
18839484 |
|
Cites |
J Comput Assist Tomogr. 2001 Sep-Oct;25(5):805-16 |
11584245 |
|
Cites |
Hum Brain Mapp. 2002 Jan;15(1):1-25 |
11747097 |
|
Cites |
Med Image Anal. 2002 Jun;6(2):129-42 |
12045000 |
|
Cites |
Neurosci Lett. 2003 Feb 27;338(2):91-4 |
12566160 |
|
Cites |
J Comput Assist Tomogr. 1996 Jan-Feb;20(1):88-97 |
8576488 |
|
Cites |
IEEE Trans Med Imaging. 1998 Jun;17(3):463-8 |
9735909 |
|
Cites |
Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4872-7 |
15772166 |
|
Cites |
Med Image Comput Comput Assist Interv. 2005;8(Pt 2):943-50 |
16686051 |
|
Cites |
Magn Reson Med. 2006 Aug;56(2):411-21 |
16788917 |
|
Cites |
Neuroimage. 2007 Jan 1;34(1):44-60 |
17035049 |
|
Cites |
Neuroimage. 2007 Feb 1;34(3):924-38 |
17161622 |
|
Cites |
Neuroimage. 2007 Oct 15;38(1):95-113 |
17761438 |
|
Cites |
IEEE Trans Med Imaging. 2008 Jan;27(1):129-41 |
18270068 |
|
Cites |
Neuroimage. 2001 Sep;14(3):595-606 |
11506533 |
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GRANTS |
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GRANTID |
AGENCY |
COUNTRY |
R01 HD050735 |
NICHD NIH HHS |
United States |
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GENERAL NOTE |
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KEYWORDS |
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MESH HEADINGS |
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DESCRIPTORNAME |
QUALIFIERNAME |
Algorithms |
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Brain |
physiology |
Diffusion Magnetic Resonance Imaging |
methods |
Female |
methods |
Humans |
methods |
Image Enhancement |
methods |
Image Interpretation, Computer-Assisted |
methods |
Imaging, Three-Dimensional |
methods |
Male |
methods |
Pattern Recognition, Automated |
methods |
Reproducibility of Results |
methods |
Sensitivity and Specificity |
methods |
Subtraction Technique |
methods |
Twins, Dizygotic |
genetics |
Twins, Monozygotic |
genetics |
Young Adult |
genetics |
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SUPPLEMENTARY MESH |
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GENE SYMBOLS |
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CHEMICALS |
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OTHER ID's |
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OTHERID |
SOURCE |
NIHMS284178 |
NLM |
PMC3086551 |
NLM |
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