Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
About GenEpi
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
18982692
TITLE
A tensor-based morphometry study of genetic influences on brain structure using a new fluid registration method.
ABSTRACT
We incorporated a new Riemannian fluid registration algorithm into a general MRI analysis method called tensor-based morphometry to map the heritability of brain morphology in MR images from 23 monozygotic and 23 dizygotic twin pairs. All 92 3D scans were fluidly registered to a common template. Voxelwise Jacobian determinants were computed from the deformation fields to assess local volumetric differences across subjects. Heritability maps were computed from the intraclass correlations and their significance was assessed using voxelwise permutation tests. Lobar volume heritability was also studied using the ACE genetic model. The performance of this Riemannian algorithm was compared to a more standard fluid registration algorithm: 3D maps from both registration techniques displayed similar heritability patterns throughout the brain. Power improvements were quantified by comparing the cumulative distribution functions of the p-values generated from both competing methods. The Riemannian algorithm outperformed the standard fluid registration.
DATE PUBLISHED
2008
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2008/11/06 09:00
medline 2008/12/31 09:00
entrez 2008/11/06 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Brun C Brun Caroline C Laboratory of Neuro Imaging, UCLA, Los Angeles, CA 90095, USA.
Leporé N Leporé Natasha N
Pennec X Pennec Xavier X
Chou YY Chou Yi-Yu YY
Lee AD Lee Agatha D AD
Barysheva M Barysheva Marina M
de Zubicaray G de Zubicaray Grieg G
Meredith M Meredith Matthew M
McMahon K McMahon Katie K
Wright MJ Wright Margaret J MJ
Toga AW Toga Arthur W AW
Thompson PM Thompson Paul M PM
INVESTIGATORS
JOURNAL
VOLUME: 11
ISSUE: Pt 2
TITLE: Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
ISOABBREVIATION: Med Image Comput Comput Assist Interv
YEAR: 2008
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN:
ISSNTYPE:
MEDLINE JOURNAL
MEDLINETA: Med Image Comput Comput Assist Interv
COUNTRY: Germany
ISSNLINKING: 1433-7851
NLMUNIQUEID: 101249582
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Nature. 2000 Mar 9;404(6774):190-3 10724172
Cites Psychol Bull. 1979 Mar;86(2):420-8 18839484
Cites J Comput Assist Tomogr. 2001 Sep-Oct;25(5):805-16 11584245
Cites Hum Brain Mapp. 2002 Jan;15(1):1-25 11747097
Cites Med Image Anal. 2002 Jun;6(2):129-42 12045000
Cites Neurosci Lett. 2003 Feb 27;338(2):91-4 12566160
Cites J Comput Assist Tomogr. 1996 Jan-Feb;20(1):88-97 8576488
Cites IEEE Trans Med Imaging. 1998 Jun;17(3):463-8 9735909
Cites Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4872-7 15772166
Cites Med Image Comput Comput Assist Interv. 2005;8(Pt 2):943-50 16686051
Cites Magn Reson Med. 2006 Aug;56(2):411-21 16788917
Cites Neuroimage. 2007 Jan 1;34(1):44-60 17035049
Cites Neuroimage. 2007 Feb 1;34(3):924-38 17161622
Cites Neuroimage. 2007 Oct 15;38(1):95-113 17761438
Cites IEEE Trans Med Imaging. 2008 Jan;27(1):129-41 18270068
Cites Neuroimage. 2001 Sep;14(3):595-606 11506533
GRANTS
GRANTID AGENCY COUNTRY
R01 HD050735 NICHD NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Algorithms
Brain physiology
Diffusion Magnetic Resonance Imaging methods
Female methods
Humans methods
Image Enhancement methods
Image Interpretation, Computer-Assisted methods
Imaging, Three-Dimensional methods
Male methods
Pattern Recognition, Automated methods
Reproducibility of Results methods
Sensitivity and Specificity methods
Subtraction Technique methods
Twins, Dizygotic genetics
Twins, Monozygotic genetics
Young Adult genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS284178 NLM
PMC3086551 NLM