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| PMID |
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| TITLE |
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| Brain fiber architecture, genetics, and intelligence: a high angular resolution diffusion imaging (HARDI) study. |
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| ABSTRACT |
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| We developed an analysis pipeline enabling population studies of HARDI data, and applied it to map genetic influences on fiber architecture in 90 twin subjects. We applied tensor-driven 3D fluid registration to HARDI, resampling the spherical fiber orientation distribution functions (ODFs) in appropriate Riemannian manifolds, after ODF regularization and sharpening. Fitting structural equation models (SEM) from quantitative genetics, we evaluated genetic influences on the Jensen-Shannon divergence (JSD), a novel measure of fiber spatial coherence, and on the generalized fiber anisotropy (GFA) a measure of fiber integrity. With random-effects regression, we mapped regions where diffusion profiles were highly correlated with subjects' intelligence quotient (IQ). Fiber complexity was predominantly under genetic control, and higher in more highly anisotropic regions; the proportion of genetic versus environmental control varied spatially. Our methods show promise for discovering genes affecting fiber connectivity in the brain. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2008/11/05 09:00 |
| medline |
2008/12/17 09:00 |
| entrez |
2008/11/05 09:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Chiang MC |
|
Chiang |
Ming-Chang |
MC |
|
Laboratory of Neuro Imaging, Dept. of Neurology, UCLA School of Medicine, Los Angeles, CA, USA. |
| Barysheva M |
|
Barysheva |
Marina |
M |
|
|
| Lee AD |
|
Lee |
Agatha D |
AD |
|
|
| Madsen S |
|
Madsen |
Sarah |
S |
|
|
| Klunder AD |
|
Klunder |
Andrea D |
AD |
|
|
| Toga AW |
|
Toga |
Arthur W |
AW |
|
|
| Mcmahon KL |
|
Mcmahon |
Katie L |
KL |
|
|
| de Zubicaray GI |
|
de Zubicaray |
Greig I |
GI |
|
|
| Meredith M |
|
Meredith |
Matthew |
M |
|
|
| Wright MJ |
|
Wright |
Margaret J |
MJ |
|
|
| Srivastava A |
|
Srivastava |
Anuj |
A |
|
|
| Balov N |
|
Balov |
Nikolay |
N |
|
|
| Thompson PM |
|
Thompson |
Paul M |
PM |
|
|
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| INVESTIGATORS |
|
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| JOURNAL |
|
| VOLUME: 11 |
| ISSUE: Pt 1 |
| TITLE: Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention |
| ISOABBREVIATION: Med Image Comput Comput Assist Interv |
| YEAR: 2008 |
| MONTH: |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: |
| ISSNTYPE: |
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| MEDLINE JOURNAL |
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| MEDLINETA: Med Image Comput Comput Assist Interv |
| COUNTRY: Germany |
| ISSNLINKING: 1433-7851 |
| NLMUNIQUEID: 101249582 |
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| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Twin Study |
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| COMMENTS AND CORRECTIONS |
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| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
| Cites |
Magn Reson Med. 2004 Dec;52(6):1358-72 |
15562495 |
|
| Cites |
Magn Reson Med. 1999 Sep;42(3):515-25 |
10467296 |
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| Cites |
J Consult Clin Psychol. 1994 Aug;62(4):757-65 |
7962879 |
|
| Cites |
IEEE Trans Med Imaging. 2001 Nov;20(11):1131-9 |
11700739 |
|
| Cites |
Med Image Anal. 2001 Jun;5(2):143-56 |
11516708 |
|
| Cites |
Med Image Comput Comput Assist Interv. 2005;8(Pt 1):115-22 |
16685836 |
|
| Cites |
IEEE Trans Med Imaging. 2008 Apr;27(4):442-56 |
18390342 |
|
| Cites |
Magn Reson Med. 2007 Sep;58(3):497-510 |
17763358 |
|
| Cites |
Neuroimage. 2007 Mar;35(1):70-82 |
17208460 |
|
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| GRANTS |
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| GRANTID |
AGENCY |
COUNTRY |
| R01 HD050735 |
NICHD NIH HHS |
United States |
| R01 HD050735 |
NICHD NIH HHS |
United States |
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| GENERAL NOTE |
|
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| KEYWORDS |
|
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| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Algorithms |
|
| Brain |
anatomy & histology |
| Diffusion |
anatomy & histology |
| Female |
anatomy & histology |
| Humans |
anatomy & histology |
| Image Enhancement |
methods |
| Image Interpretation, Computer-Assisted |
methods |
| Intelligence |
genetics |
| Magnetic Resonance Imaging |
methods |
| Male |
methods |
| Nerve Fibers, Myelinated |
ultrastructure |
| Pattern Recognition, Automated |
methods |
| Reproducibility of Results |
methods |
| Sensitivity and Specificity |
methods |
| Twins |
genetics |
| Young Adult |
genetics |
|
| SUPPLEMENTARY MESH |
|
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| GENE SYMBOLS |
|
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| CHEMICALS |
|
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| OTHER ID's |
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| OTHERID |
SOURCE |
| NIHMS284179 |
NLM |
| PMC3073165 |
NLM |
|
|
