Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
18927547
TITLE
Common genetic components of obesity traits and serum leptin.
ABSTRACT
To estimate common and distinct genetic influences on a panel of obesity-related traits and serum leptin level in adults. In a cross-sectional study of 625 Danish, adult, healthy, monozygotic, and same-sex dizygotic twin pairs of both genders, we carried out detailed anthropometry (height, weight, waist and hip, and skin-fold thickness, body composition assessment by bioimpedance (fat mass and fat-free mass), and measurement of serum leptin level. Bivariate variance component analyses estimated the additive genetic correlations between these measurements. The genetic correlations between the traits for overall fatness (BMI and fat mass index, kg/m(2)) were 0.94 in men and 0.98 in women, and their correlations with the various local fatness measures ranged from 0.49 to 0.83 in men and from 0.70 to 0.87 in women. The correlations between the truncal measures (waist circumference and truncal skin folds) and between the peripheral measures (hip circumference and peripheral skin folds) were 0.57 and 0.47 in men and 0.71 and 0.70 in women, respectively. The correlations between the truncal and peripheral measures ranged between 0.49 and 0.72 in men and between 0.61 and 0.82 in women. For leptin vs. the various measures of overall and local fatness the correlations ranged from 0.54 to 0.74 in men and from 0.48 to 0.75 in women. All correlations were significantly <1.00. The study supports control of overall fat mass and peripheral and truncal fat mass by both shared and different genetic components, which suggests that it is important to distinguish between the different phenotypes in the search for genes involved in the development of obesity.
DATE PUBLISHED
2008 Dec
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2008/10/16
pubmed 2008/10/18 09:00
medline 2009/04/04 09:00
entrez 2008/10/18 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Hasselbalch AL Hasselbalch Ann L AL Institute of Preventive Medicine, Copenhagen University Hospital, Copenhagen, Denmark.
Benyamin B Benyamin Beben B
Visscher PM Visscher Peter M PM
Heitmann BL Heitmann Berit L BL
Kyvik KO Kyvik Kirsten O KO
Sørensen TI Sørensen Thorkild I A TI
INVESTIGATORS
JOURNAL
VOLUME: 16
ISSUE: 12
TITLE: Obesity (Silver Spring, Md.)
ISOABBREVIATION: Obesity (Silver Spring)
YEAR: 2008
MONTH: Dec
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1930-7381
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Obesity (Silver Spring)
COUNTRY: United States
ISSNLINKING: 1930-7381
NLMUNIQUEID: 101264860
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adipose Tissue
Adult
Body Composition genetics
Body Mass Index genetics
Body Weight genetics
Cross-Sectional Studies genetics
Denmark genetics
Diseases in Twins genetics
Environment genetics
Female genetics
Humans genetics
Leptin blood
Male blood
Middle Aged blood
Obesity genetics
Phenotype genetics
Skinfold Thickness genetics
Twins, Dizygotic genetics
Twins, Monozygotic genetics
Waist Circumference genetics
Young Adult genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Leptin
OTHER ID's