Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
18824185
TITLE
Genetic influences on handedness: data from 25,732 Australian and Dutch twin families.
ABSTRACT
Handedness refers to a consistent asymmetry in skill or preferential use between the hands and is related to lateralization within the brain of other functions such as language. Previous twin studies of handedness have yielded inconsistent results resulting from a general lack of statistical power to find significant effects. Here we present analyses from a large international collaborative study of handedness (assessed by writing/drawing or self report) in Australian and Dutch twins and their siblings (54,270 individuals from 25,732 families). Maximum likelihood analyses incorporating the effects of known covariates (sex, year of birth and birth weight) revealed no evidence of hormonal transfer, mirror imaging or twin specific effects. There were also no differences in prevalence between zygosity groups or between twins and their singleton siblings. Consistent with previous meta-analyses, additive genetic effects accounted for about a quarter (23.64%) of the variance (95%CI 20.17, 27.09%) with the remainder accounted for by non-shared environmental influences. The implications of these findings for handedness both as a primary phenotype and as a covariate in linkage and association analyses are discussed.
DATE PUBLISHED
2009 Jan
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2008/05/24
revised 2008/08/12
accepted 2008/09/02
pubmed 2008/10/01 09:00
medline 2009/04/14 09:00
entrez 2008/10/01 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Medland SE Medland Sarah E SE Queensland Institute of Medical Research, Australia. sarahMe@qimr.edu.au
Duffy DL Duffy David L DL
Wright MJ Wright Margaret J MJ
Geffen GM Geffen Gina M GM
Hay DA Hay David A DA
Levy F Levy Florence F
van-Beijsterveldt CE van-Beijsterveldt Catherina E M CE
Willemsen G Willemsen Gonneke G
Townsend GC Townsend Grant C GC
White V White Vicki V
Hewitt AW Hewitt Alex W AW
Mackey DA Mackey David A DA
Bailey JM Bailey J Michael JM
Slutske WS Slutske Wendy S WS
Nyholt DR Nyholt Dale R DR
Treloar SA Treloar Susan A SA
Martin NG Martin Nicholas G NG
Boomsma DI Boomsma Dorret I DI
INVESTIGATORS
JOURNAL
VOLUME: 47
ISSUE: 2
TITLE: Neuropsychologia
ISOABBREVIATION: Neuropsychologia
YEAR: 2009
MONTH: Jan
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0028-3932
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Neuropsychologia
COUNTRY: England
ISSNLINKING: 0028-3932
NLMUNIQUEID: 0020713
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
R01 MH58799-03 NIMH NIH HHS United States
R01 MH066206-05 NIMH NIH HHS United States
R01 MH066206 NIMH NIH HHS United States
P50 AA011998 NIAAA NIH HHS United States
R01 MH066206-02 NIMH NIH HHS United States
R01 AA007728 NIAAA NIH HHS United States
DA12854 NIDA NIH HHS United States
R56 DA012854 NIDA NIH HHS United States
MH66206 NIMH NIH HHS United States
R01 MH058799 NIMH NIH HHS United States
R01 MH058799-03 NIMH NIH HHS United States
AA07728 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
R01 DA012854 NIDA NIH HHS United States
R01 AA010249 NIAAA NIH HHS United States
R01 MH066206-03 NIMH NIH HHS United States
R37 AA007728 NIAAA NIH HHS United States
R01 MH066206-04 NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Aged
Aged, 80 and over
Algorithms
Australia epidemiology
Birth Weight physiology
Child physiology
Cohort Studies physiology
Female physiology
Functional Laterality genetics
Humans genetics
Male genetics
Middle Aged genetics
Models, Statistical genetics
Netherlands epidemiology
Reproducibility of Results epidemiology
Twins epidemiology
Twins, Dizygotic epidemiology
Twins, Monozygotic epidemiology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
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