Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
18779828
TITLE
Genetic influences on the difference in variability of height, weight and body mass index between Caucasian and East Asian adolescent twins.
ABSTRACT
OBJECTIVE NlmCategory: OBJECTIVE
Twin studies are useful for investigating the causes of trait variation between as well as within a population. The goals of the present study were two-fold: First, we aimed to compare the total phenotypic, genetic and environmental variances of height, weight and BMI between Caucasians and East Asians using twins. Secondly, we intended to estimate the extent to which genetic and environmental factors contribute to differences in variability of height, weight and BMI between Caucasians and East Asians.
DESIGN NlmCategory: METHODS
Height and weight data from 3735 Caucasian and 1584 East Asian twin pairs (age: 13-15 years) from Australia, China, Finland, Japan, the Netherlands, South Korea, Taiwan and the United States were used for analyses. Maximum likelihood twin correlations and variance components model-fitting analyses were conducted to fulfill the goals of the present study.
RESULTS NlmCategory: RESULTS
The absolute genetic variances for height, weight and BMI were consistently greater in Caucasians than in East Asians with corresponding differences in total variances for all three body measures. In all 80 to 100% of the differences in total variances of height, weight and BMI between the two population groups were associated with genetic differences.
CONCLUSION NlmCategory: CONCLUSIONS
Height, weight and BMI were more variable in Caucasian than in East Asian adolescents. Genetic variances for these three body measures were also larger in Caucasians than in East Asians. Variance components model-fitting analyses indicated that genetic factors contributed to the difference in variability of height, weight and BMI between the two population groups. Association studies for these body measures should take account of our findings of differences in genetic variances between the two population groups.
DATE PUBLISHED
2008 Oct
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2008/09/09
pubmed 2008/09/10 09:00
medline 2009/07/02 09:00
entrez 2008/09/10 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Hur YM Hur Y-M YM Department of Psychology, Chonnam National University, Gwangju, South Korea. ymhur@snu.ac.kr
Kaprio J Kaprio J J
Iacono WG Iacono W G WG
Boomsma DI Boomsma D I DI
McGue M McGue M M
Silventoinen K Silventoinen K K
Martin NG Martin N G NG
Luciano M Luciano M M
Visscher PM Visscher P M PM
Rose RJ Rose R J RJ
He M He M M
Ando J Ando J J
Ooki S Ooki S S
Nonaka K Nonaka K K
Lin CC Lin C C H CC
Lajunen HR Lajunen H R HR
Cornes BK Cornes B K BK
Bartels M Bartels M M
van Beijsterveldt CE van Beijsterveldt C E M CE
Cherny SS Cherny S S SS
Mitchell K Mitchell K K
INVESTIGATORS
JOURNAL
VOLUME: 32
ISSUE: 10
TITLE: International journal of obesity (2005)
ISOABBREVIATION: Int J Obes (Lond)
YEAR: 2008
MONTH: Oct
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1476-5497
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Int J Obes (Lond)
COUNTRY: England
ISSNLINKING: 0307-0565
NLMUNIQUEID: 101256108
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
AA-00145 NIAAA NIH HHS United States
AA-09203 NIAAA NIH HHS United States
AA-12502 NIAAA NIH HHS United States
AA09367 NIAAA NIH HHS United States
DA05147 NIDA NIH HHS United States
DA13240 NIDA NIH HHS United States
EY-12562 NEI NIH HHS United States
MH20030 NIMH NIH HHS United States
R01 AA009367 NIAAA NIH HHS United States
R01 AA009367-16 NIAAA NIH HHS United States
R01 DA005147 NIDA NIH HHS United States
R01 DA005147-20 NIDA NIH HHS United States
R01 DA013240 NIDA NIH HHS United States
R01 DA013240-08 NIDA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Asian Continental Ancestry Group genetics
Body Height genetics
Body Mass Index genetics
Body Weight genetics
European Continental Ancestry Group genetics
Female genetics
Humans genetics
Male genetics
Sex Characteristics genetics
Twins, Dizygotic genetics
Twins, Monozygotic genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS70793 NLM
PMC2577073 NLM
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