Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
18778383
TITLE
Alcohol dependence and reproductive onset: findings in two Australian twin cohorts.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Although early alcohol use is a strong predictor of future alcohol problems and adolescent drinking is associated with risky sexual behavior predictive of early childbearing, reproductive dysfunctions associated with delayed childbearing have been reported in adult drinkers. We examine the relationship between lifetime history of alcohol dependence (AD) and timing of first childbirth across reproductive development.
METHODS NlmCategory: METHODS
Data were drawn from two cohorts of Australian twins born between 1893 and 1964 (3634 female and 1880 male twins) and between 1964 and 1971 (3381 female and 2748 male twins). Survival analyses were conducted using Cox proportional hazards regression models predicting age at first childbirth from AD, with sociodemographic characteristics, regular smoking, history of psychopathology, and family and childhood risks included as control variables in adjusted models.
RESULTS NlmCategory: RESULTS
Results suggest alcoholic women in both cohorts show overall delayed reproduction, with little effect of AD on timing of first reproduction in men. Effects of AD are particularly strong for women in the older cohort, where AD is associated with 73% decreased likelihood of first childbirth after age 29 [hazard ratio (HR) = 0.27, 95% CI: 0.10-0.75]. In adjusted models, effects reduce only slightly (HR = 0.29, 95% CI: 0.11-0.80). For women in the young cohort, AD is associated with delayed reproduction after age 24, with 40% decreased likelihood of first childbirth (HR = 0.60, 95% CI: 0.48-0.75). AD remains predictive in adjusted models, but without age interaction (HR = 0.72, 95% CI: 0.62-0.85).
CONCLUSIONS NlmCategory: CONCLUSIONS
Findings of delayed reproductive onset in alcoholic women are consistent with alcohol-related reproductive dysfunctions, although underlying mechanisms remain largely unknown. To better understand AD differences in reproductive onset, continued research on both biological and psychosocial risks is needed.
DATE PUBLISHED
2008 Nov
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2008/09/05
pubmed 2008/09/10 09:00
medline 2009/02/10 09:00
entrez 2008/09/10 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Waldron M Waldron Mary M Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA. maryw@matlock.wustl.edu
Heath AC Heath Andrew C AC
Bucholz KK Bucholz Kathleen K KK
Madden PA Madden Pamela A F PA
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 32
ISSUE: 11
TITLE: Alcoholism, clinical and experimental research
ISOABBREVIATION: Alcohol. Clin. Exp. Res.
YEAR: 2008
MONTH: Nov
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1530-0277
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Alcohol Clin Exp Res
COUNTRY: England
ISSNLINKING: 0145-6008
NLMUNIQUEID: 7707242
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Alcohol Res Health. 2001;25(4):282-7 11910706
Cites Arch Gen Psychiatry. 2007 Jul;64(7):830-42 17606817
Cites Alcohol Clin Exp Res. 1984 Sep-Oct;8(5):451-8 6391255
Cites Acta Genet Med Gemellol (Roma). 1984;33(3):435-50 6543278
Cites Behav Genet. 1985 Jul;15(4):305-47 4041178
Cites Behav Genet. 1985 Mar;15(2):93-109 3838073
Cites J Pharmacol Exp Ther. 1988 May;245(2):407-12 3367299
Cites Fam Plann Perspect. 1988 May-Jun;20(3):128-36 3417003
Cites Am J Public Health. 1990 Mar;80(3):295-9 2305908
Cites Br J Addict. 1991 Oct;86(10):1269-81 1836409
Cites Am J Public Health. 1993 Jun;83(6):830-7 8498620
Cites Am J Psychiatry. 1994 May;151(5):707-15 8166312
Cites Addiction. 1999 Sep;94(9):1361-70 10615721
Cites J Adolesc Health. 2000 Jan;26(1):42-8 10638717
Cites Addiction. 2000 Feb;95(2):251-65 10723854
Cites Matern Child Health J. 1997 Jun;1(2):81-8 10728230
Cites Addiction. 1999 Oct;94(10):1477-87 10790900
Cites Fam Plann Perspect. 2000 Jul-Aug;32(4):166-75 10942352
Cites Addiction. 2001 Apr;96(4):607-21 11300964
Cites Evolution. 2001 Feb;55(2):423-35 11308097
Cites Br J Psychiatry Suppl. 2001 Apr;40:s33-40 11315223
Cites Twin Res. 2001 Apr;4(2):73-80 11665339
Cites Alcohol Alcohol. 2002 Jan-Feb;37(1):87-92 11825863
Cites J Biosoc Sci. 2002 Apr;34(2):259-75 11926458
Cites Am J Health Behav. 2002 Nov-Dec;26(6):473-85 12437022
Cites Alcohol Clin Exp Res. 2003 Jan;27(1):93-9 12544012
Cites Alcohol Res Health. 2002;26(4):274-81 12875037
Cites Am J Health Behav. 2004 Jan-Feb;28(1):3-12 14977154
Cites Acta Genet Stat Med. 1966;16(3):265-75 4959152
Cites J Stud Alcohol. 1994 Mar;55(2):149-58 8189735
Cites Am J Public Health. 1994 Jul;84(7):1116-20 8017535
Cites Fam Plann Perspect. 1994 Nov-Dec;26(6):257-63 7867773
Cites Fam Plann Perspect. 1995 Jan-Feb;27(1):18-22, 33 7720848
Cites Fam Plann Perspect. 1995 Jan-Feb;27(1):23-8 7720849
Cites Am J Health Promot. 1995 Sep-Oct;10(1):27-36 10155656
Cites Int J Addict. 1995 Sep;30(11):1453-78 8530215
Cites Pediatrics. 1996 Jul;98(1):91-6 8668418
Cites J Health Soc Behav. 1996 Dec;37(4):339-49 8997889
Cites Int J Androl. 1996 Dec;19(6):323-37 9051418
Cites Alcohol Alcohol. 1997 May-Jun;32(3):211-9 9199721
Cites Sex Transm Dis. 1997 Jul;24(6):313-9 9243736
Cites J Stud Alcohol. 1997 Sep;58(5):464-73 9273910
Cites Am J Psychiatry. 1997 Oct;154(10):1405-11 9326823
Cites Psychol Med. 1997 Nov;27(6):1381-96 9403910
Cites J Subst Abuse. 1997;9:103-10 9494942
Cites Addict Behav. 1998 May-Jun;23(3):419-25 9668941
Cites Hum Reprod. 1998 Jun;13(6):1532-9 9688387
Cites Fam Plann Perspect. 1998 Jul-Aug;30(4):163-9 9711453
Cites BMJ. 1998 Aug 22;317(7157):505-10 9712595
Cites Fertil Steril. 1998 Oct;70(4):632-7 9797089
Cites Pediatrics. 1998 Nov;102(5):1185-92 9794952
Cites Fam Plann Perspect. 1998 Nov-Dec;30(6):271-5 9859017
Cites Am J Psychiatry. 1999 Jan;156(1):34-40 9892295
Cites J Adolesc Health. 1999 Sep;25(3):179-81 10475493
Cites Alcohol Res Health. 2000;24(4):209-14 15986715
Cites J Child Psychol Psychiatry. 2006 Jan;47(1):16-24 16405636
Cites Psychol Med. 2006 Oct;36(10):1461-71 16734942
Cites Alcohol Res Health. 2006;29(3):172-8 17373405
Cites Alcohol Clin Exp Res. 2007 May;31(5):717-28 17378921
Cites JAMA. 1977 Nov 14;238(20):2143 578821
GRANTS
GRANTID AGENCY COUNTRY
AA07728 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
AA15210 NIAAA NIH HHS United States
HD49024 NICHD NIH HHS United States
P50 AA011998 NIAAA NIH HHS United States
P50 AA011998-10 NIAAA NIH HHS United States
R01 AA015210 NIAAA NIH HHS United States
R01 AA015210-04 NIAAA NIH HHS United States
R01 HD049024 NICHD NIH HHS United States
R01 HD049024-04 NICHD NIH HHS United States
R37 AA007728 NIAAA NIH HHS United States
R37 AA007728-20 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Age Factors
Aged
Aged, 80 and over
Alcoholism physiopathology
Australia physiopathology
Cohort Studies physiopathology
Female physiopathology
Health Surveys physiopathology
Humans physiopathology
Male physiopathology
Maternal Age physiopathology
Middle Aged physiopathology
Proportional Hazards Models physiopathology
Reproduction physiology
Reproductive Physiological Phenomena physiology
Substance-Related Disorders physiopathology
Survival Analysis physiopathology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS58643 NLM
PMC2588479 NLM
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