Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
18729607
TITLE
Searching for an environmental effect of parental alcoholism on offspring alcohol use disorder: a genetically informed study of children of alcoholics.
ABSTRACT
The children-of-twins design was used to isolate a potentially causal environmental impact of having an alcoholic parent on offspring alcohol use disorder, by an examination of whether the children of alcoholics were at a higher risk for alcohol use disorders than were the children of nonalcoholic parents, even after correlated familial factors were controlled. Participants were 1,224 male and female twins from 836 twin pairs selected from the Australian Twin Registry, 2,334 of the twins' 18-39-year-old offspring, and 983 spouses of the twins. Lifetime histories of Diagnostic and Statistical Manual of Mental Disorders (4th ed.) alcohol use disorders were obtained by structured, psychiatric, telephone interviews conducted individually with each of the family members. Comparisons of the offspring of twins who were discordant for alcoholism indicated that there was no longer a statistically significant difference between the children of alcoholics and the children of nonalcoholics after genetic and family environmental factors correlated with having an alcoholic parent were controlled. The results of this study suggest that the direct causal effect of being exposed to an alcoholic parent on offspring alcohol use disorder is modest at best.
Copyright (c) 2008 APA, all rights reserved.
DATE PUBLISHED
2008 Aug
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2008/08/30 09:00
medline 2008/10/22 09:00
entrez 2008/08/30 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Slutske WS Slutske Wendy S WS Department of Psychological Sciences, Midwest Alcoholism Research Center, University of Missouri-Columbia, Columbia, MO 65211, USA. slutskew@missouri.edu
D'Onofrio BM D'Onofrio Brian M BM
Turkheimer E Turkheimer Eric E
Emery RE Emery Robert E RE
Harden KP Harden K Paige KP
Heath AC Heath Andrew C AC
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 117
ISSUE: 3
TITLE: Journal of abnormal psychology
ISOABBREVIATION: J Abnorm Psychol
YEAR: 2008
MONTH: Aug
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0021-843X
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: J Abnorm Psychol
COUNTRY: United States
ISSNLINKING: 0021-843X
NLMUNIQUEID: 0034461
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
AA00264 NIAAA NIH HHS United States
AA011998 NIAAA NIH HHS United States
AA07535 NIAAA NIH HHS United States
AA10249 NIAAA NIH HHS United States
HD056354 NICHD NIH HHS United States
K01 AA000264 NIAAA NIH HHS United States
K01 AA000264-03 NIAAA NIH HHS United States
K01 AA000264-04 NIAAA NIH HHS United States
K01 AA000264-05 NIAAA NIH HHS United States
P50 AA011998 NIAAA NIH HHS United States
P50 AA011998-060005 NIAAA NIH HHS United States
P50 AA011998-070005 NIAAA NIH HHS United States
P50 AA011998-080005 NIAAA NIH HHS United States
P50 AA011998-090005 NIAAA NIH HHS United States
P50 AA011998-100005 NIAAA NIH HHS United States
R01 HD056354 NICHD NIH HHS United States
R01 HD056354-01 NICHD NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Alcoholism genetics
Child genetics
Child of Impaired Parents statistics & numerical data
Diagnostic and Statistical Manual of Mental Disorders statistics & numerical data
Female statistics & numerical data
Genetic Predisposition to Disease statistics & numerical data
Humans statistics & numerical data
Male statistics & numerical data
Parents statistics & numerical data
Pedigree statistics & numerical data
Prevalence statistics & numerical data
Severity of Illness Index statistics & numerical data
Social Environment statistics & numerical data
Twins genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS59312 NLM
PMC2830724 NLM
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Last Modified: Oct 15 2007