|
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| PMID |
|
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| TITLE |
|
| Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. |
|
| ABSTRACT |
|
|
|
| To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder. |
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| DATE PUBLISHED |
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| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2008/02/22 |
| accepted |
2008/06/13 |
| aheadofprint |
2008/08/17 |
| pubmed |
2008/08/20 09:00 |
| medline |
2009/02/10 09:00 |
| entrez |
2008/08/20 09:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Ferreira MA |
|
Ferreira |
Manuel A R |
MA |
|
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. |
| O'Donovan MC |
|
O'Donovan |
Michael C |
MC |
|
|
| Meng YA |
|
Meng |
Yan A |
YA |
|
|
| Jones IR |
|
Jones |
Ian R |
IR |
|
|
| Ruderfer DM |
|
Ruderfer |
Douglas M |
DM |
|
|
| Jones L |
|
Jones |
Lisa |
L |
|
|
| Fan J |
|
Fan |
Jinbo |
J |
|
|
| Kirov G |
|
Kirov |
George |
G |
|
|
| Perlis RH |
|
Perlis |
Roy H |
RH |
|
|
| Green EK |
|
Green |
Elaine K |
EK |
|
|
| Smoller JW |
|
Smoller |
Jordan W |
JW |
|
|
| Grozeva D |
|
Grozeva |
Detelina |
D |
|
|
| Stone J |
|
Stone |
Jennifer |
J |
|
|
| Nikolov I |
|
Nikolov |
Ivan |
I |
|
|
| Chambert K |
|
Chambert |
Kimberly |
K |
|
|
| Hamshere ML |
|
Hamshere |
Marian L |
ML |
|
|
| Nimgaonkar VL |
|
Nimgaonkar |
Vishwajit L |
VL |
|
|
| Moskvina V |
|
Moskvina |
Valentina |
V |
|
|
| Thase ME |
|
Thase |
Michael E |
ME |
|
|
| Caesar S |
|
Caesar |
Sian |
S |
|
|
| Sachs GS |
|
Sachs |
Gary S |
GS |
|
|
| Franklin J |
|
Franklin |
Jennifer |
J |
|
|
| Gordon-Smith K |
|
Gordon-Smith |
Katherine |
K |
|
|
| Ardlie KG |
|
Ardlie |
Kristin G |
KG |
|
|
| Gabriel SB |
|
Gabriel |
Stacey B |
SB |
|
|
| Fraser C |
|
Fraser |
Christine |
C |
|
|
| Blumenstiel B |
|
Blumenstiel |
Brendan |
B |
|
|
| Defelice M |
|
Defelice |
Matthew |
M |
|
|
| Breen G |
|
Breen |
Gerome |
G |
|
|
| Gill M |
|
Gill |
Michael |
M |
|
|
| Morris DW |
|
Morris |
Derek W |
DW |
|
|
| Elkin A |
|
Elkin |
Amanda |
A |
|
|
| Muir WJ |
|
Muir |
Walter J |
WJ |
|
|
| McGhee KA |
|
McGhee |
Kevin A |
KA |
|
|
| Williamson R |
|
Williamson |
Richard |
R |
|
|
| MacIntyre DJ |
|
MacIntyre |
Donald J |
DJ |
|
|
| MacLean AW |
|
MacLean |
Alan W |
AW |
|
|
| St CD |
|
St |
Clair David |
CD |
|
|
| Robinson M |
|
Robinson |
Michelle |
M |
|
|
| Van Beck M |
|
Van Beck |
Margaret |
M |
|
|
| Pereira AC |
|
Pereira |
Ana C P |
AC |
|
|
| Kandaswamy R |
|
Kandaswamy |
Radhika |
R |
|
|
| McQuillin A |
|
McQuillin |
Andrew |
A |
|
|
| Collier DA |
|
Collier |
David A |
DA |
|
|
| Bass NJ |
|
Bass |
Nicholas J |
NJ |
|
|
| Young AH |
|
Young |
Allan H |
AH |
|
|
| Lawrence J |
|
Lawrence |
Jacob |
J |
|
|
| Ferrier IN |
|
Ferrier |
I Nicol |
IN |
|
|
| Anjorin A |
|
Anjorin |
Adebayo |
A |
|
|
| Farmer A |
|
Farmer |
Anne |
A |
|
|
| Curtis D |
|
Curtis |
David |
D |
|
|
| Scolnick EM |
|
Scolnick |
Edward M |
EM |
|
|
| McGuffin P |
|
McGuffin |
Peter |
P |
|
|
| Daly MJ |
|
Daly |
Mark J |
MJ |
|
|
| Corvin AP |
|
Corvin |
Aiden P |
AP |
|
|
| Holmans PA |
|
Holmans |
Peter A |
PA |
|
|
| Blackwood DH |
|
Blackwood |
Douglas H |
DH |
|
|
| Gurling HM |
|
Gurling |
Hugh M |
HM |
|
|
| Owen MJ |
|
Owen |
Michael J |
MJ |
|
|
| Purcell SM |
|
Purcell |
Shaun M |
SM |
|
|
| Sklar P |
|
Sklar |
Pamela |
P |
|
|
| Craddock N |
|
Craddock |
Nick |
N |
|
|
|
Wellcome Trust Case Control Consortium |
|
|
|
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 40 |
| ISSUE: 9 |
| TITLE: Nature genetics |
| ISOABBREVIATION: Nat. Genet. |
| YEAR: 2008 |
| MONTH: Sep |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1061-4036 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Nat Genet |
| COUNTRY: United States |
| ISSNLINKING: 1061-4036 |
| NLMUNIQUEID: 9216904 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
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| Cites |
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| Cites |
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| Cites |
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| Cites |
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| Cites |
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15793588 |
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| Cites |
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7836469 |
|
| CommentIn |
Nat Genet. 2008 Sep;40(9):1042-4 |
19165917 |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| 076113 |
Wellcome Trust |
United Kingdom |
| 077011 |
Wellcome Trust |
United Kingdom |
| 082371 |
Wellcome Trust |
United Kingdom |
| G0500791 |
Medical Research Council |
United Kingdom |
| G0701003 |
Medical Research Council |
United Kingdom |
| G9309834 |
Medical Research Council |
United Kingdom |
| G9623693N |
Medical Research Council |
United Kingdom |
| MH062137 |
NIMH NIH HHS |
United States |
| MH063445 |
NIMH NIH HHS |
United States |
| MH067288 |
NIMH NIH HHS |
United States |
| MH63420 |
NIMH NIH HHS |
United States |
| N01MH80001 |
NIMH NIH HHS |
United States |
| U54 RR020278 |
NCRR NIH HHS |
United States |
|
Chief Scientist Office |
United Kingdom |
|
Wellcome Trust |
United Kingdom |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Ankyrins |
genetics |
| Bipolar Disorder |
genetics |
| Calcium Channels, L-Type |
genetics |
| Chromosomes, Human, Pair 10 |
genetics |
| Chromosomes, Human, Pair 12 |
genetics |
| Chromosomes, Human, Pair 15 |
genetics |
| Genetic Predisposition to Disease |
genetics |
| Genome-Wide Association Study |
genetics |
| Humans |
genetics |
| Logistic Models |
genetics |
| Polymorphism, Single Nucleotide |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
ANK3 protein, human |
| 0 |
Ankyrins |
| 0 |
CACNA1C protein, human |
| 0 |
Calcium Channels, L-Type |
|
| OTHER ID's |
|
| OTHERID |
SOURCE |
| PMC2703780 |
NLM |
| UKMS27163 |
NLM |
|
|
