Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
18711365
TITLE
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
ABSTRACT
To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.
DATE PUBLISHED
2008 Sep
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2008/02/22
accepted 2008/06/13
aheadofprint 2008/08/17
pubmed 2008/08/20 09:00
medline 2009/02/10 09:00
entrez 2008/08/20 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Ferreira MA Ferreira Manuel A R MA Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
O'Donovan MC O'Donovan Michael C MC
Meng YA Meng Yan A YA
Jones IR Jones Ian R IR
Ruderfer DM Ruderfer Douglas M DM
Jones L Jones Lisa L
Fan J Fan Jinbo J
Kirov G Kirov George G
Perlis RH Perlis Roy H RH
Green EK Green Elaine K EK
Smoller JW Smoller Jordan W JW
Grozeva D Grozeva Detelina D
Stone J Stone Jennifer J
Nikolov I Nikolov Ivan I
Chambert K Chambert Kimberly K
Hamshere ML Hamshere Marian L ML
Nimgaonkar VL Nimgaonkar Vishwajit L VL
Moskvina V Moskvina Valentina V
Thase ME Thase Michael E ME
Caesar S Caesar Sian S
Sachs GS Sachs Gary S GS
Franklin J Franklin Jennifer J
Gordon-Smith K Gordon-Smith Katherine K
Ardlie KG Ardlie Kristin G KG
Gabriel SB Gabriel Stacey B SB
Fraser C Fraser Christine C
Blumenstiel B Blumenstiel Brendan B
Defelice M Defelice Matthew M
Breen G Breen Gerome G
Gill M Gill Michael M
Morris DW Morris Derek W DW
Elkin A Elkin Amanda A
Muir WJ Muir Walter J WJ
McGhee KA McGhee Kevin A KA
Williamson R Williamson Richard R
MacIntyre DJ MacIntyre Donald J DJ
MacLean AW MacLean Alan W AW
St CD St Clair David CD
Robinson M Robinson Michelle M
Van Beck M Van Beck Margaret M
Pereira AC Pereira Ana C P AC
Kandaswamy R Kandaswamy Radhika R
McQuillin A McQuillin Andrew A
Collier DA Collier David A DA
Bass NJ Bass Nicholas J NJ
Young AH Young Allan H AH
Lawrence J Lawrence Jacob J
Ferrier IN Ferrier I Nicol IN
Anjorin A Anjorin Adebayo A
Farmer A Farmer Anne A
Curtis D Curtis David D
Scolnick EM Scolnick Edward M EM
McGuffin P McGuffin Peter P
Daly MJ Daly Mark J MJ
Corvin AP Corvin Aiden P AP
Holmans PA Holmans Peter A PA
Blackwood DH Blackwood Douglas H DH
Gurling HM Gurling Hugh M HM
Owen MJ Owen Michael J MJ
Purcell SM Purcell Shaun M SM
Sklar P Sklar Pamela P
Craddock N Craddock Nick N
Wellcome Trust Case Control Consortium
INVESTIGATORS
JOURNAL
VOLUME: 40
ISSUE: 9
TITLE: Nature genetics
ISOABBREVIATION: Nat. Genet.
YEAR: 2008
MONTH: Sep
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1061-4036
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Mol Psychiatry. 2008 Jun;13(6):558-69 18317468
Cites Nat Rev Neurosci. 2003 Dec;4(12):968-80 14682359
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Cites Pharmacogenet Genomics. 2007 Aug;17(8):605-17 17622937
Cites Nature. 2007 Jun 7;447(7145):661-78 17554300
Cites Nat Genet. 2007 May;39(5):631-7 17401366
Cites Nat Genet. 2007 May;39(5):596-604 17435756
Cites Science. 2007 Jun 1;316(5829):1331-6 17463246
Cites PLoS Genet. 2006 Sep 22;2(9):e157 17002500
Cites Biol Psychiatry. 2006 Jul 15;60(2):177-85 16497276
Cites Nature. 2005 Oct 27;437(7063):1299-320 16255080
Cites Nat Genet. 2005 Apr;37(4):413-7 15793588
Cites J Biol Chem. 1995 Feb 3;270(5):2352-9 7836469
CommentIn Nat Genet. 2008 Sep;40(9):1042-4 19165917
GRANTS
GRANTID AGENCY COUNTRY
076113 Wellcome Trust United Kingdom
077011 Wellcome Trust United Kingdom
082371 Wellcome Trust United Kingdom
G0500791 Medical Research Council United Kingdom
G0701003 Medical Research Council United Kingdom
G9309834 Medical Research Council United Kingdom
G9623693N Medical Research Council United Kingdom
MH062137 NIMH NIH HHS United States
MH063445 NIMH NIH HHS United States
MH067288 NIMH NIH HHS United States
MH63420 NIMH NIH HHS United States
N01MH80001 NIMH NIH HHS United States
U54 RR020278 NCRR NIH HHS United States
Chief Scientist Office United Kingdom
Wellcome Trust United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Ankyrins genetics
Bipolar Disorder genetics
Calcium Channels, L-Type genetics
Chromosomes, Human, Pair 10 genetics
Chromosomes, Human, Pair 12 genetics
Chromosomes, Human, Pair 15 genetics
Genetic Predisposition to Disease genetics
Genome-Wide Association Study genetics
Humans genetics
Logistic Models genetics
Polymorphism, Single Nucleotide genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 ANK3 protein, human
0 Ankyrins
0 CACNA1C protein, human
0 Calcium Channels, L-Type
OTHER ID's
OTHERID SOURCE
PMC2703780 NLM
UKMS27163 NLM