Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
18647812
TITLE
A genome-wide linkage scan for age at menarche in three populations of European descent.
ABSTRACT
CONTEXT NlmCategory: BACKGROUND
Age at menarche (AAM) is an important trait both biologically and socially, a clearly defined event in female pubertal development, and has been associated with many clinically significant phenotypes.
OBJECTIVE NlmCategory: OBJECTIVE
The objective of the study was to identify genetic loci influencing variation in AAM in large population-based samples from three countries.
DESIGN/PARTICIPANTS NlmCategory: METHODS
Recalled AAM data were collected from 13,697 individuals and 4,899 pseudoindependent sister-pairs from three different populations (Australia, The Netherlands, and the United Kingdom) by mailed questionnaire or interview. Genome-wide variance components linkage analysis was implemented on each sample individually and in combination.
RESULTS NlmCategory: RESULTS
The mean, sd, and heritability of AAM across the three samples was 13.1 yr, 1.5 yr, and 0.69, respectively. No loci were detected that reached genome-wide significance in the combined analysis, but a suggestive locus was detected on chromosome 12 (logarithm of the odds = 2.0). Three loci of suggestive significance were seen in the U.K. sample on chromosomes 1, 4, and 18 (logarithm of the odds = 2.4, 2.2 and 3.2, respectively).
CONCLUSIONS NlmCategory: CONCLUSIONS
There was no evidence for common highly penetrant variants influencing AAM. Linkage and association suggest that one trait locus for AAM is located on chromosome 12, but further studies are required to replicate these results.
DATE PUBLISHED
2008 Oct
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2008/07/22
pubmed 2008/07/24 09:00
medline 2008/12/17 09:00
entrez 2008/07/24 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Anderson CA Anderson Carl A CA Queensland Institute of Medical Research, Royal Brisbane Hospital, Queensland 4029, Australia.
Zhu G Zhu Gu G
Falchi M Falchi Mario M
van den Berg SM van den Berg St├ęphanie M SM
Treloar SA Treloar Susan A SA
Spector TD Spector Timothy D TD
Martin NG Martin Nicholas G NG
Boomsma DI Boomsma Dorret I DI
Visscher PM Visscher Peter M PM
Montgomery GW Montgomery Grant W GW
INVESTIGATORS
JOURNAL
VOLUME: 93
ISSUE: 10
TITLE: The Journal of clinical endocrinology and metabolism
ISOABBREVIATION: J. Clin. Endocrinol. Metab.
YEAR: 2008
MONTH: Oct
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0021-972X
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: J Clin Endocrinol Metab
COUNTRY: United States
ISSNLINKING: 0021-972X
NLMUNIQUEID: 0375362
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Comparative Study
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
AA00277 NIAAA NIH HHS United States
AA07535 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
AA09022 NIAAA NIH HHS United States
AA10249 NIAAA NIH HHS United States
AA10333 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
CA88363 NCI NIH HHS United States
DA00272 NIDA NIH HHS United States
DA12854 NIDA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Age Distribution
Australia
Child
Chromosome Mapping
European Continental Ancestry Group genetics
Female genetics
Genetic Linkage genetics
Genetics, Population genetics
Genome, Human genetics
Great Britain genetics
Humans genetics
Lod Score genetics
Menarche physiology
Netherlands physiology
Siblings physiology
Twins genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC2579643 NLM