Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
18606503
TITLE
Autosomal linkage analysis for cannabis use behaviors in Australian adults.
ABSTRACT
Cannabis is the most commonly used illicit drug in developed and in developing nations. Twin studies have highlighted the role of genetic influences on early stages of cannabis use, such as a lifetime history of use, early-onset use and frequent use, however, we are not aware of any genomic studies that have examined these phenotypes. Using data on 2314 families consisting of 5600 adult Australian offspring and their parents, all of whom were scanned using 1399 unique autosomal markers, we conducted autosomal linkage analyses for lifetime history of cannabis initiation, early-onset cannabis use and frequency of use, using a variance components approach in the linkage package MERLIN. Suggestive evidence for linkage was found on chromosome 18 (LOD 2.14 for frequency of use, LOD 1.97 for initiation, at 90-97 cM) and also on chromosome 19 (LOD 1.92 for early-onset at 17 cM). These LOD scores did not meet genome-wide significance. Further replication of these linkage regions in other samples will be required, although these initial results suggest further targeted efforts on chromosome 18 may yield interesting candidate genes for early stages of cannabis-related behaviors.
DATE PUBLISHED
2008 Dec 1
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2007/10/30
revised 2008/04/15
accepted 2008/05/18
aheadofprint 2008/07/07
pubmed 2008/07/09 09:00
medline 2009/01/24 09:00
entrez 2008/07/09 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Agrawal A Agrawal Arpana A Washington University School of Medicine, Department of Psychiatry, 660 South Euclid Avenue, St. Louis, MO 63108, USA. arpana@matlock.wustl.edu
Morley KI Morley Katherine I KI
Hansell NK Hansell Narelle K NK
Pergadia ML Pergadia Michele L ML
Montgomery GW Montgomery Grant W GW
Statham DJ Statham Dixie J DJ
Todd RD Todd Richard D RD
Madden PA Madden Pamela A F PA
Heath AC Heath Andrew C AC
Whitfield J Whitfield John J
Martin NG Martin Nicholas G NG
Lynskey MT Lynskey Michael T MT
INVESTIGATORS
JOURNAL
VOLUME: 98
ISSUE: 3
TITLE: Drug and alcohol dependence
ISOABBREVIATION: Drug Alcohol Depend
YEAR: 2008
MONTH: Dec
DAY: 1
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0376-8716
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Drug Alcohol Depend
COUNTRY: Ireland
ISSNLINKING: 0376-8716
NLMUNIQUEID: 7513587
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
AA 07580 NIAAA NIH HHS United States
AA 07728 NIAAA NIH HHS United States
AA 13320 NIAAA NIH HHS United States
AA 13321 NIAAA NIH HHS United States
DA 019951 NIDA NIH HHS United States
DA 023668 NIDA NIH HHS United States
DA 12854 NIDA NIH HHS United States
DA 18267 NIDA NIH HHS United States
DA 18660 NIDA NIH HHS United States
K08 DA019951 NIDA NIH HHS United States
K08 DA019951-04 NIDA NIH HHS United States
R01 AA007728 NIAAA NIH HHS United States
R01 AA007728-05 NIAAA NIH HHS United States
R01 AA013320-05 NIAAA NIH HHS United States
R01 AA013321 NIAAA NIH HHS United States
R01 AA013321-05 NIAAA NIH HHS United States
R01 DA012854 NIDA NIH HHS United States
R01 DA012854-06A2 NIDA NIH HHS United States
R01 DA018267-04 NIDA NIH HHS United States
R01 DA018660-05 NIDA NIH HHS United States
R01 DA023668 NIDA NIH HHS United States
R01 DA023668-01 NIDA NIH HHS United States
R01 DA023668-02 NIDA NIH HHS United States
R37 AA007728 NIAAA NIH HHS United States
R37 AA007728-20 NIAAA NIH HHS United States
T32 AA007580 NIAAA NIH HHS United States
T32 AA007580-05 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Age of Onset
Aged
Aged, 80 and over
Alcoholism genetics
Australia epidemiology
Cohort Studies epidemiology
Female epidemiology
Genetic Linkage epidemiology
Genotype epidemiology
Humans epidemiology
Male epidemiology
Marijuana Smoking genetics
Middle Aged genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS74217 NLM
PMC2584346 NLM
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