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| PMID |
|
|
| TITLE |
|
| Evidence of shared genes in refraction and axial length: the Genes in Myopia (GEM) twin study. |
|
| ABSTRACT |
|
| PURPOSE |
NlmCategory: OBJECTIVE |
| Axial length has been shown to explain up to 50% of the total variance in refraction, with axial length and refraction having a major genetic component. However, no study has attempted to determine whether the correlation between axial length and refraction is explained by shared genetic or environmental factors. |
| METHODS |
NlmCategory: METHODS |
| All twins from Victoria aged 18 years or older were invited to participate in the Genes in Myopia (GEM) twin study through the Australian Twin Registry (ATR). Each twin completed a general questionnaire and underwent dilated objective refraction assessment and measurement of axial length. |
| RESULTS |
NlmCategory: RESULTS |
| A total of 612 twin pairs (1224 twins) aged from 18 to 86 years were examined in the GEM twin study. Axial length correlated negatively with refraction (r = -0.64 in the men, r = -0.68 in the women; P < 0.01). The sex limitation ADE (A, additive genetic; D, dominant genetic; E, unique environmental factors) model provided the best-fit genetic model for both measures. Of the variation in spherical equivalence in both the men and the women, approximately 50% were due to genetic factors influencing axial length. |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| From these findings, it is likely that axial length and refraction share common genes in their etiology. The GEM twin study has provided a basis and direction for future research into identifying the gene(s) in axial length that will ultimately improve our understanding of the etiology of refractive error, particularly myopia. |
|
| DATE PUBLISHED |
|
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| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| aheadofprint |
2008/06/14 |
| pubmed |
2008/06/17 09:00 |
| medline |
2008/10/11 09:00 |
| entrez |
2008/06/17 09:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Dirani M |
|
Dirani |
Mohamed |
M |
|
Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia. dirani@unimelb.edu.au. |
| Shekar SN |
|
Shekar |
Sri N |
SN |
|
|
| Baird PN |
|
Baird |
Paul N |
PN |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 49 |
| ISSUE: 10 |
| TITLE: Investigative ophthalmology & visual science |
| ISOABBREVIATION: Invest. Ophthalmol. Vis. Sci. |
| YEAR: 2008 |
| MONTH: Oct |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1552-5783 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Invest Ophthalmol Vis Sci |
| COUNTRY: United States |
| ISSNLINKING: 0146-0404 |
| NLMUNIQUEID: 7703701 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
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| GENERAL NOTE |
|
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| KEYWORDS |
|
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| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Adult |
|
| Aged |
|
| Aged, 80 and over |
|
| Body Weights and Measures |
|
| Diseases in Twins |
genetics |
| Eye |
pathology |
| Female |
pathology |
| Humans |
pathology |
| Male |
pathology |
| Middle Aged |
pathology |
| Models, Genetic |
pathology |
| Myopia |
genetics |
| Questionnaires |
genetics |
| Refraction, Ocular |
genetics |
| Registries |
genetics |
| Twins, Dizygotic |
genetics |
| Twins, Monozygotic |
genetics |
| Victoria |
genetics |
|
| SUPPLEMENTARY MESH |
|
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| GENE SYMBOLS |
|
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| CHEMICALS |
|
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| OTHER ID's |
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|
