Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
18533058
TITLE
Accumulation of trauma over time and risk for depression in a twin sample.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Few genetically informative studies have examined the effects of different types of trauma on risk for depression over time. The aim of the present study was to examine the relative contributions over time of assaultive trauma, non-assaultive trauma, and familial effects to risk for depression.
METHOD NlmCategory: METHODS
Histories of depression and trauma were obtained during structured diagnostic interviews with 5266 (mean age 29.9 years, s.d.=2.4) members of a volunteer Australian twin panel from the general population. Age at first onset of a DSM-IV major depressive episode was the dependent variable. Associations of depression with traumatic events were examined while accounting for the temporal sequence of trauma and depression and familial effects.
RESULTS NlmCategory: RESULTS
Assaultive traumatic events that occurred during childhood had the strongest association with immediate and long-term risk for depression, and outweighed familial effects on childhood-onset depression for most twins. Although men and women endorsed equal rates of assaultive trauma, women reported a greater accumulation of assaultive events at earlier ages than men, whereas men reported a greater accumulation of non-assaultive events at all ages.
CONCLUSIONS NlmCategory: CONCLUSIONS
Early exposure to assaultive trauma can influence risk for depression into adulthood. Concordance for early trauma is a significant contributor to the familiality of early-onset depression.
DATE PUBLISHED
2009 Mar
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2008/06/04
pubmed 2008/06/06 09:00
medline 2009/06/06 09:00
entrez 2008/06/06 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
McCutcheon VV McCutcheon V V VV Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA. vmccutcheon@wustl.edu
Heath AC Heath A C AC
Nelson EC Nelson E C EC
Bucholz KK Bucholz K K KK
Madden PA Madden P A F PA
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 39
ISSUE: 3
TITLE: Psychological medicine
ISOABBREVIATION: Psychol Med
YEAR: 2009
MONTH: Mar
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0033-2917
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Psychol Med
COUNTRY: England
ISSNLINKING: 0033-2917
NLMUNIQUEID: 1254142
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
5 T32 MH19960-08 NIMH NIH HHS United States
AA07728 NIAAA NIH HHS United States
AA10240 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
AA12640 NIAAA NIH HHS United States
F31 MH071039 NIMH NIH HHS United States
F31 MH071039-01 NIMH NIH HHS United States
F31 MH071039-01 NIMH NIH HHS United States
T32 AA07580 NIAAA NIH HHS United States
T32 MH019960 NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Age of Onset
Australia epidemiology
Depressive Disorder genetics
Depressive Disorder, Major genetics
Diseases in Twins epidemiology
Female epidemiology
Health Status epidemiology
Humans epidemiology
Life Change Events epidemiology
Male epidemiology
Psychiatric Status Rating Scales epidemiology
Questionnaires epidemiology
Risk Factors epidemiology
Sex Factors epidemiology
Stress Disorders, Traumatic psychology
Twins, Dizygotic psychology
Twins, Monozygotic psychology
Violence statistics & numerical data
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS191277 NLM
PMC2855227 NLM
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