|
|
| PMID |
|
|
| TITLE |
|
| An autosomal linkage scan for cannabis use disorders in the nicotine addiction genetics project. |
|
| ABSTRACT |
|
| CONTEXT |
NlmCategory: BACKGROUND |
| Despite accumulating evidence that there is a genetic basis for cannabis use disorders (ie, abuse and dependence), few studies have identified genomic regions that may harbor biological risk and protective factors. |
| OBJECTIVE |
NlmCategory: OBJECTIVE |
| To conduct autosomal linkage analyses that identify genomic regions that may harbor genes conferring a vulnerability to cannabis use disorders. |
| DESIGN |
NlmCategory: METHODS |
| In 289 Australian families who participated in the Nicotine Addiction Genetics Project, 423 autosomal markers were genotyped. Families were ascertained for heavy cigarette smoking. Linkage was conducted for DSM-IV cannabis dependence and for a novel factor score representing problems with cannabis use, including occurrence of 3 of 4 abuse criteria (excluding legal problems) and 6 DSM-IV dependence criteria. |
| RESULTS |
NlmCategory: RESULTS |
| A maximum logarithm of odds (LOD) of 3.36 was noted for the cannabis problems factor score on chromosome arm 1p. An LOD of 2.2 was noted on chromosome 4 in the region of the gamma-aminobutyric acid type A gene cluster, including GABRA2, which has been implicated in drug use disorders. For DSM-IV cannabis dependence, a modest LOD score on chromosome 6 (1.42) near cannabinoid receptor 1 (CNR1) was identified. In addition, support for an elevation on chromosome 3, identified in prior independent studies, was noted for the factor score and cannabis dependence (LOD, 1.4). |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| Genes such as ELTD1 on chromosome 1, in addition to genes on chromosomes 4 (eg, GABRA2) and 6 (eg, CNR1), may be associated with the genetic risk for cannabis use disorders. We introduce a novel quantitative phenotype, a cannabis problems factor score composed of DSM-IV abuse and dependence criteria, that may be useful for future linkage and association studies. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2008/06/04 09:00 |
| medline |
2008/06/18 09:00 |
| entrez |
2008/06/04 09:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Agrawal A |
|
Agrawal |
Arpana |
A |
|
Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8134, St Louis, MO 63110, USA. arpana@wustl.edu |
| Pergadia ML |
|
Pergadia |
Michele L |
ML |
|
|
| Saccone SF |
|
Saccone |
Scott F |
SF |
|
|
| Lynskey MT |
|
Lynskey |
Michael T |
MT |
|
|
| Wang JC |
|
Wang |
Jen C |
JC |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
| Statham D |
|
Statham |
Dixie |
D |
|
|
| Henders A |
|
Henders |
Anjali |
A |
|
|
| Campbell M |
|
Campbell |
Megan |
M |
|
|
| Garcia R |
|
Garcia |
Robertino |
R |
|
|
| Broms U |
|
Broms |
Ulla |
U |
|
|
| Todd RD |
|
Todd |
Richard D |
RD |
|
|
| Goate AM |
|
Goate |
Alison M |
AM |
|
|
| Rice J |
|
Rice |
John |
J |
|
|
| Kaprio J |
|
Kaprio |
Jaakko |
J |
|
|
| Heath AC |
|
Heath |
Andrew C |
AC |
|
|
| Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
|
| Madden PA |
|
Madden |
Pamela A F |
PA |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 65 |
| ISSUE: 6 |
| TITLE: Archives of general psychiatry |
| ISOABBREVIATION: Arch. Gen. Psychiatry |
| YEAR: 2008 |
| MONTH: Jun |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1538-3636 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Arch Gen Psychiatry |
| COUNTRY: United States |
| ISSNLINKING: 0003-990X |
| NLMUNIQUEID: 0372435 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Multicenter Study |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| AA07580 |
NIAAA NIH HHS |
United States |
| AA07728 |
NIAAA NIH HHS |
United States |
| AA13320 |
NIAAA NIH HHS |
United States |
| AA13321 |
NIAAA NIH HHS |
United States |
| DA019951 |
NIDA NIH HHS |
United States |
| DA023668 |
NIDA NIH HHS |
United States |
| DA12854 |
NIDA NIH HHS |
United States |
| DA18267 |
NIDA NIH HHS |
United States |
| DA18660 |
NIDA NIH HHS |
United States |
| K08 DA019951 |
NIDA NIH HHS |
United States |
| K08 DA019951-03 |
NIDA NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Australia |
|
| Cell Adhesion Molecules, Neuronal |
|
| Chromosome Aberrations |
|
| Chromosome Mapping |
|
| Chromosomes, Human, Pair 1 |
genetics |
| Chromosomes, Human, Pair 4 |
genetics |
| Chromosomes, Human, Pair 6 |
genetics |
| Diseases in Twins |
genetics |
| Female |
genetics |
| Genetic Markers |
genetics |
| Genetic Predisposition to Disease |
genetics |
| Humans |
genetics |
| Lod Score |
genetics |
| Male |
genetics |
| Marijuana Abuse |
genetics |
| Middle Aged |
genetics |
| Neuropeptides |
genetics |
| Phenotype |
genetics |
| Receptors, Cell Surface |
genetics |
| Receptors, G-Protein-Coupled |
genetics |
| Receptors, GABA-A |
genetics |
| Tobacco Use Disorder |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
Cell Adhesion Molecules, Neuronal |
| 0 |
ELTD1 protein, human |
| 0 |
GABRA2 protein, human |
| 0 |
Genetic Markers |
| 0 |
Neuropeptides |
| 0 |
PCDHA4 protein, human |
| 0 |
Receptors, Cell Surface |
| 0 |
Receptors, G-Protein-Coupled |
| 0 |
Receptors, GABA-A |
|
| OTHER ID's |
|
|
|
