Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
18493267
TITLE
Testing replication of a 5-SNP set for general cognitive ability in six population samples.
ABSTRACT
A 5-single nucleotide polymorphism (SNP) set has been associated with general cognitive ability in 5000 7-year-old children from the Twins Early Development Study (TEDS). Four of these SNPs were identified through a 10 K microarray analysis and one was identified through a targeted analysis of brain-expressed genes. The present study tested this association with general cognitive ability in six population samples of varying size and age from Australia, the UK (Scotland and England) and the Netherlands. Results from the largest sample (N=1310) approached significance (P=0.06) in the direction of the original finding, but results from the other samples (N=205-758) were mixed. A meta-analysis of the results--allowing for effect size heterogeneity between samples--yielded a non-significant correlation (r=-0.01, P=0.57), indicating that this SNP set was not associated with general cognitive ability in the populations studied.
DATE PUBLISHED
2008 Nov
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2008/05/21
pubmed 2008/05/22 09:00
medline 2009/07/25 09:00
entrez 2008/05/22 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Luciano M Luciano Michelle M Department of Psychology, MRC Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. michelle.luciano@ed.ac.uk
Lind PA Lind Penelope A PA
Deary IJ Deary Ian J IJ
Payton A Payton Antony A
Posthuma D Posthuma Danielle D
Butcher LM Butcher Lee M LM
Bochdanovits Z Bochdanovits Zoltan Z
Whalley LJ Whalley Lawrence J LJ
Visscher PM Visscher Peter M PM
Harris SE Harris Sarah E SE
Polderman TJ Polderman Tinca J C TJ
Davis OS Davis Oliver S P OS
Wright MJ Wright Margaret J MJ
Starr JM Starr John M JM
de Geus EJ de Geus Eco J C EJ
Bates TC Bates Timothy C TC
Montgomery GW Montgomery Grant W GW
Boomsma DI Boomsma Dorret I DI
Martin NG Martin Nicholas G NG
Plomin R Plomin Robert R
INVESTIGATORS
JOURNAL
VOLUME: 16
ISSUE: 11
TITLE: European journal of human genetics : EJHG
ISOABBREVIATION: Eur. J. Hum. Genet.
YEAR: 2008
MONTH: Nov
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1018-4813
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Eur J Hum Genet
COUNTRY: England
ISSNLINKING: 1018-4813
NLMUNIQUEID: 9302235
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
075492 Wellcome Trust United Kingdom
CZB/4/505 Chief Scientist Office United Kingdom
ETM/55 Chief Scientist Office United Kingdom
G0500079 Medical Research Council United Kingdom
G0500079 Medical Research Council United Kingdom
G0500079(73692) Medical Research Council United Kingdom
GR75492 Wellcome Trust United Kingdom
S18386 Biotechnology and Biological Sciences Research Council United Kingdom
Biotechnology and Biological Sciences Research Council United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Child
Child, Preschool
Cognition
Female
Follow-Up Studies
Humans
Male
Meta-Analysis as Topic
Polymorphism, Single Nucleotide
Twins, Dizygotic
Twins, Monozygotic
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's