|
|
| PMID |
|
|
| TITLE |
|
| Testing replication of a 5-SNP set for general cognitive ability in six population samples. |
|
| ABSTRACT |
|
|
|
| A 5-single nucleotide polymorphism (SNP) set has been associated with general cognitive ability in 5000 7-year-old children from the Twins Early Development Study (TEDS). Four of these SNPs were identified through a 10 K microarray analysis and one was identified through a targeted analysis of brain-expressed genes. The present study tested this association with general cognitive ability in six population samples of varying size and age from Australia, the UK (Scotland and England) and the Netherlands. Results from the largest sample (N=1310) approached significance (P=0.06) in the direction of the original finding, but results from the other samples (N=205-758) were mixed. A meta-analysis of the results--allowing for effect size heterogeneity between samples--yielded a non-significant correlation (r=-0.01, P=0.57), indicating that this SNP set was not associated with general cognitive ability in the populations studied. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| aheadofprint |
2008/05/21 |
| pubmed |
2008/05/22 09:00 |
| medline |
2009/07/25 09:00 |
| entrez |
2008/05/22 09:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Luciano M |
|
Luciano |
Michelle |
M |
|
Department of Psychology, MRC Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. michelle.luciano@ed.ac.uk |
| Lind PA |
|
Lind |
Penelope A |
PA |
|
|
| Deary IJ |
|
Deary |
Ian J |
IJ |
|
|
| Payton A |
|
Payton |
Antony |
A |
|
|
| Posthuma D |
|
Posthuma |
Danielle |
D |
|
|
| Butcher LM |
|
Butcher |
Lee M |
LM |
|
|
| Bochdanovits Z |
|
Bochdanovits |
Zoltan |
Z |
|
|
| Whalley LJ |
|
Whalley |
Lawrence J |
LJ |
|
|
| Visscher PM |
|
Visscher |
Peter M |
PM |
|
|
| Harris SE |
|
Harris |
Sarah E |
SE |
|
|
| Polderman TJ |
|
Polderman |
Tinca J C |
TJ |
|
|
| Davis OS |
|
Davis |
Oliver S P |
OS |
|
|
| Wright MJ |
|
Wright |
Margaret J |
MJ |
|
|
| Starr JM |
|
Starr |
John M |
JM |
|
|
| de Geus EJ |
|
de Geus |
Eco J C |
EJ |
|
|
| Bates TC |
|
Bates |
Timothy C |
TC |
|
|
| Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
|
| Boomsma DI |
|
Boomsma |
Dorret I |
DI |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
| Plomin R |
|
Plomin |
Robert |
R |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 16 |
| ISSUE: 11 |
| TITLE: European journal of human genetics : EJHG |
| ISOABBREVIATION: Eur. J. Hum. Genet. |
| YEAR: 2008 |
| MONTH: Nov |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1018-4813 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Eur J Hum Genet |
| COUNTRY: England |
| ISSNLINKING: 1018-4813 |
| NLMUNIQUEID: 9302235 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Multicenter Study |
| Research Support, Non-U.S. Gov't |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| 075492 |
Wellcome Trust |
United Kingdom |
| CZB/4/505 |
Chief Scientist Office |
United Kingdom |
| ETM/55 |
Chief Scientist Office |
United Kingdom |
| G0500079 |
Medical Research Council |
United Kingdom |
| G0500079 |
Medical Research Council |
United Kingdom |
| G0500079(73692) |
Medical Research Council |
United Kingdom |
| GR75492 |
Wellcome Trust |
United Kingdom |
| S18386 |
Biotechnology and Biological Sciences Research Council |
United Kingdom |
|
Biotechnology and Biological Sciences Research Council |
United Kingdom |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Adult |
|
| Child |
|
| Child, Preschool |
|
| Cognition |
|
| Female |
|
| Follow-Up Studies |
|
| Humans |
|
| Male |
|
| Meta-Analysis as Topic |
|
| Polymorphism, Single Nucleotide |
|
| Twins, Dizygotic |
|
| Twins, Monozygotic |
|
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
|
