| PMID |
|
|
| TITLE |
|
| Common sequence variants on 20q11.22 confer melanoma susceptibility. |
|
| ABSTRACT |
|
|
|
| We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2008/03/06 |
| accepted |
2008/04/30 |
| aheadofprint |
2008/05/18 |
| pubmed |
2008/05/20 09:00 |
| medline |
2008/07/23 09:00 |
| entrez |
2008/05/20 09:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Brown KM |
|
Brown |
Kevin M |
KM |
|
Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, Arizona 85028, USA. |
| Macgregor S |
|
Macgregor |
Stuart |
S |
|
|
| Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
|
| Craig DW |
|
Craig |
David W |
DW |
|
|
| Zhao ZZ |
|
Zhao |
Zhen Zhen |
ZZ |
|
|
| Iyadurai K |
|
Iyadurai |
Kelly |
K |
|
|
| Henders AK |
|
Henders |
Anjali K |
AK |
|
|
| Homer N |
|
Homer |
Nils |
N |
|
|
| Campbell MJ |
|
Campbell |
Megan J |
MJ |
|
|
| Stark M |
|
Stark |
Mitchell |
M |
|
|
| Thomas S |
|
Thomas |
Shane |
S |
|
|
| Schmid H |
|
Schmid |
Helen |
H |
|
|
| Holland EA |
|
Holland |
Elizabeth A |
EA |
|
|
| Gillanders EM |
|
Gillanders |
Elizabeth M |
EM |
|
|
| Duffy DL |
|
Duffy |
David L |
DL |
|
|
| Maskiell JA |
|
Maskiell |
Judith A |
JA |
|
|
| Jetann J |
|
Jetann |
Jodie |
J |
|
|
| Ferguson M |
|
Ferguson |
Megan |
M |
|
|
| Stephan DA |
|
Stephan |
Dietrich A |
DA |
|
|
| Cust AE |
|
Cust |
Anne E |
AE |
|
|
| Whiteman D |
|
Whiteman |
David |
D |
|
|
| Green A |
|
Green |
Adele |
A |
|
|
| Olsson H |
|
Olsson |
Håkan |
H |
|
|
| Puig S |
|
Puig |
Susana |
S |
|
|
| Ghiorzo P |
|
Ghiorzo |
Paola |
P |
|
|
| Hansson J |
|
Hansson |
Johan |
J |
|
|
| Demenais F |
|
Demenais |
Florence |
F |
|
|
| Goldstein AM |
|
Goldstein |
Alisa M |
AM |
|
|
| Gruis NA |
|
Gruis |
Nelleke A |
NA |
|
|
| Elder DE |
|
Elder |
David E |
DE |
|
|
| Bishop JN |
|
Bishop |
Julia Newton |
JN |
|
|
| Kefford RF |
|
Kefford |
Richard F |
RF |
|
|
| Giles GG |
|
Giles |
Graham G |
GG |
|
|
| Armstrong BK |
|
Armstrong |
Bruce K |
BK |
|
|
| Aitken JF |
|
Aitken |
Joanne F |
JF |
|
|
| Hopper JL |
|
Hopper |
John L |
JL |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
| Trent JM |
|
Trent |
Jeffrey M |
JM |
|
|
| Mann GJ |
|
Mann |
Graham J |
GJ |
|
|
| Hayward NK |
|
Hayward |
Nicholas K |
NK |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 40 |
| ISSUE: 7 |
| TITLE: Nature genetics |
| ISOABBREVIATION: Nat. Genet. |
| YEAR: 2008 |
| MONTH: Jul |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1546-1718 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Nat Genet |
| COUNTRY: United States |
| ISSNLINKING: 1061-4036 |
| NLMUNIQUEID: 9216904 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
| Cites |
J Natl Cancer Inst. 2005 Jul 6;97(13):998-1007 |
15998953 |
|
| Cites |
Am J Hum Genet. 2000 Jan;66(1):176-86 |
10631149 |
|
| Cites |
Am J Hum Genet. 2002 Mar;70(3):770-5 |
11833005 |
|
| Cites |
Br J Dermatol. 2004 Feb;150(2):179-85 |
14996086 |
|
| Cites |
Hum Genet. 2005 Apr;116(5):402-6 |
15726415 |
|
| Cites |
Nucleic Acids Res. 2008 Apr;36(6):e35 |
18276640 |
|
| Cites |
J Dermatol Sci. 2005 Nov;40(2):133-6 |
16183259 |
|
| Cites |
Cancer Lett. 2005 Dec 18;230(2):153-86 |
16297704 |
|
| Cites |
Nucleic Acids Res. 2006;34(7):e55 |
16627870 |
|
| Cites |
Pigment Cell Res. 2007 Jun;20(3):216-21 |
17516929 |
|
| Cites |
Twin Res Hum Genet. 2008 Apr;11(2):183-96 |
18361720 |
|
| CommentIn |
Nat Genet. 2008 Jul;40(7):817-8 |
18583973 |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| CA083115 |
NCI NIH HHS |
United States |
| CA109544 |
NCI NIH HHS |
United States |
| CA83115 |
NCI NIH HHS |
United States |
| CA88363 |
NCI NIH HHS |
United States |
| HL086528 |
NHLBI NIH HHS |
United States |
| R01 CA083115 |
NCI NIH HHS |
United States |
| R01 CA083115-08 |
NCI NIH HHS |
United States |
| R01 CA088363 |
NCI NIH HHS |
United States |
| R01 CA088363-07 |
NCI NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Age of Onset |
|
| Case-Control Studies |
|
| Chromosomes, Human, Pair 20 |
|
| Genetic Predisposition to Disease |
|
| Humans |
|
| Linkage Disequilibrium |
|
| Melanoma |
genetics |
| Odds Ratio |
genetics |
| Polymorphism, Single Nucleotide |
genetics |
| Skin Neoplasms |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
| OTHERID |
SOURCE |
| NIHMS130202 |
NLM |
| PMC2755512 |
NLM |
|
