|
|
| PMID |
|
|
| TITLE |
|
| Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control study. |
|
| ABSTRACT |
|
| AIMS |
NlmCategory: OBJECTIVE |
| The gamma-aminobutyric acid receptor A (GABRA) gene clusters on chromosomes 4 and 5 have been examined previously for their association with alcohol and drug dependence phenotypes. Compelling evidence suggests that GABRA2 is associated with alcohol and drug dependence. However, no study has investigated whether genes in the GABA(A) gene clusters are associated with nicotine dependence, an important phenotype with a high correlation to persistent smoking, the single most preventable cause of mortality world-wide. |
| DESIGN |
NlmCategory: METHODS |
| Using data on 1050 nicotine-dependent cases and 879 non-dependent smoking controls, we used logistic regression to examine the association between single nucleotide polymorphisms (SNPs) in 13 genes in the GABA(A) receptor system as well as GABBR2 (a GABA(B) gene). |
| FINDINGS |
NlmCategory: RESULTS |
| We found evidence for association between four SNPs in GABRA4, two SNPs in GABRA2 and one SNP in GABRE with nicotine dependence. These included a synonymous polymorphism in GABRA2 (rs279858), lying in a highly conserved region, which has been shown previously to be associated with alcohol and drug dependence. A non-synonymous polymorphism (rs16859834/rs2229940) in GABRA4, also highly conserved, was associated at P-value of 0.03. Significant haplotypes associated with nicotine dependence were found for GABRA2. No evidence for epistatic interactions were noted. Our study did not find evidence for an association between GABBR2 gene and nicotine dependence. |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| Given the potential role of compounds that enhance GABAergic neurotransmission in smoking cessation research, these findings have enormous potential for informing the wider field of addiction research. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2008/05/17 09:00 |
| medline |
2008/08/15 09:00 |
| entrez |
2008/05/17 09:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Agrawal A |
|
Agrawal |
Arpana |
A |
|
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA. arpana@wustl.edu |
| Pergadia ML |
|
Pergadia |
Michele L |
ML |
|
|
| Saccone SF |
|
Saccone |
Scott F |
SF |
|
|
| Hinrichs AL |
|
Hinrichs |
Anthony L |
AL |
|
|
| Lessov-Schlaggar CN |
|
Lessov-Schlaggar |
Christina N |
CN |
|
|
| Saccone NL |
|
Saccone |
Nancy L |
NL |
|
|
| Neuman RJ |
|
Neuman |
Rosalind J |
RJ |
|
|
| Breslau N |
|
Breslau |
Naomi |
N |
|
|
| Johnson E |
|
Johnson |
Eric |
E |
|
|
| Hatsukami D |
|
Hatsukami |
Dorothy |
D |
|
|
| Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
|
| Heath AC |
|
Heath |
Andrew C |
AC |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
| Goate AM |
|
Goate |
Alison M |
AM |
|
|
| Rice JP |
|
Rice |
John P |
JP |
|
|
| Bierut LJ |
|
Bierut |
Laura J |
LJ |
|
|
| Madden PA |
|
Madden |
Pamela A F |
PA |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 103 |
| ISSUE: 6 |
| TITLE: Addiction (Abingdon, England) |
| ISOABBREVIATION: Addiction |
| YEAR: 2008 |
| MONTH: Jun |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0965-2140 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Addiction |
| COUNTRY: England |
| ISSNLINKING: 0965-2140 |
| NLMUNIQUEID: 9304118 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Multicenter Study |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
| Research Support, U.S. Gov't, Non-P.H.S. |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| CA89392 |
NCI NIH HHS |
United States |
| DA015129 |
NIDA NIH HHS |
United States |
| DA019951 |
NIDA NIH HHS |
United States |
| DA12854 |
NIDA NIH HHS |
United States |
| HHSN271200477471C |
PHS HHS |
United States |
| K01DA015129 |
NIDA NIH HHS |
United States |
| K08 DA019951 |
NIDA NIH HHS |
United States |
| K08 DA019951-03 |
NIDA NIH HHS |
United States |
| N01DA-0-7079 |
NIDA NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Behavior, Addictive |
genetics |
| Case-Control Studies |
genetics |
| Chromosomes, Human, 4-5 |
genetics |
| Evidence-Based Medicine |
genetics |
| Female |
genetics |
| Genotype |
genetics |
| Humans |
genetics |
| Logistic Models |
genetics |
| Male |
genetics |
| Phenotype |
genetics |
| Receptors, GABA |
metabolism |
| Smoking Cessation |
methods |
| Tobacco Use Disorder |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
Receptors, GABA |
|
| OTHER ID's |
|
|
|
