Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
1845530
TITLE
The inheritance of alcohol sensitivity and of patterns of alcohol use.
ABSTRACT
Compared to controls, sons of alcoholics have been reported to exhibit decreased sensitivity to a challenge dose of alcohol (e.g. a smaller increase in body-sway: Schuckit, 1985). We reanalyze alcohol challenge data from a general population sample of Australian twin pairs (Martin et al., 1985a, b). By fitting direction-of-causation models, we show that in males differences in body-sway are largely a consequence, not a cause, of differences in alcohol consumption patterns. In females, direction-of-causation could not be resolved.
DATE PUBLISHED
1991
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1991/01/01
medline 1991/01/01 00:01
entrez 1991/01/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Heath AC Heath A C AC Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 1
ISSUE:
TITLE: Alcohol and alcoholism (Oxford, Oxfordshire). Supplement
ISOABBREVIATION: Alcohol Alcohol Suppl
YEAR: 1991
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1358-6173
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Alcohol Alcohol Suppl
COUNTRY: ENGLAND
ISSNLINKING: 1358-6173
NLMUNIQUEID: 8804836
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
ADAMHA AA07535 NIAAA NIH HHS United States
ADAMHA AA07728 NIAAA NIH HHS United States
ADAMHA DA05588 NIDA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Alcohol Drinking
Alcoholic Intoxication physiopathology
Alcoholism genetics
Analysis of Variance genetics
Australia genetics
Ethanol toxicity
Family toxicity
Female toxicity
Humans toxicity
Male toxicity
Motor Activity toxicity
Questionnaires toxicity
Sex Factors toxicity
Twins, Dizygotic toxicity
Twins, Monozygotic toxicity
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
3K9958V90M Ethanol
OTHER ID's