Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
18433502
TITLE
Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Variation in response to the hedonic and adverse effects of a substance is in part an inherited factor that may influence its use, abuse and dependence. The mu opioid receptor is the primary site of action for opiates and individuals with polymorphisms in this receptor appear to have variation in the CNS effects of opiates. Several studies have suggested that this receptor may also mediate some of the effects of non-opioid drugs, such as alcohol. The purpose of this study was to investigate associations between 13 single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) with self-reported responses to alcohol, an endophenotype associated with the development of alcohol dependence, in American Indians living on eight contiguous reservations.
METHODS NlmCategory: METHODS
Each participant gave a blood sample and completed a structured diagnostic interview. Additionally, response to alcohol was indexed using the expectation version of the subjective high assessment scale (SHAS-E). SNPs were genotyped in 251 participants and data analyses were conducted using SOLAR.
RESULTS NlmCategory: RESULTS
The estimated heritability (h2) for the SHAS-E phenotypes ranged from 0.01 to 0.28. Endorsing the expectation of a more intense response on one or more of the following items from the SHAS-E: buzzed, clumsy, dizzy, drunk, effects, high, nausea, sleepy, talkative, terrible, and/or uncomfortable after imbibing 2-3 drinks was significantly associated with having at least one minor allele for at least one of 7 SNPs (p < 0.01) in the OPRM1 receptor gene.
CONCLUSION NlmCategory: CONCLUSIONS
These studies provide data to suggest that the minor allele, for most of the polymorphisms in the OPRM1 receptor gene investigated, was found to be associated with a more intense, and/or more adverse, response to alcohol, traits that are significantly correlated with lowered quantity of alcohol consumption and less susceptibility to dependence in this Indian population. These data further suggest that making conclusions on the role of the mu opiod receptor gene in the development of alcohol dependence may be limited if only one polymorphism in the gene is evaluated in isolation.
DATE PUBLISHED
2008
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2007/11/30
accepted 2008/04/23
aheadofprint 2008/04/23
pubmed 2008/04/25 09:00
medline 2008/05/22 09:00
entrez 2008/04/25 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Ehlers CL Ehlers Cindy L CL Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA. cindye@scripps.edu
Lind PA Lind Penelope A PA
Wilhelmsen KC Wilhelmsen Kirk C KC
INVESTIGATORS
JOURNAL
VOLUME: 9
ISSUE:
TITLE: BMC medical genetics
ISOABBREVIATION: BMC Med. Genet.
YEAR: 2008
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1471-2350
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: BMC Med Genet
COUNTRY: England
ISSNLINKING: 1471-2350
NLMUNIQUEID: 100968552
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
5R37 AA010201 NIAAA NIH HHS United States
R37 AA010201 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Alcoholism genetics
Alleles genetics
Female genetics
Genetic Markers genetics
Genetic Variation genetics
Humans genetics
Indians, North American genetics
Male genetics
Polymorphism, Single Nucleotide genetics
Receptors, Opioid, mu genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Genetic Markers
0 OPRM1 protein, human
0 Receptors, Opioid, mu
OTHER ID's
OTHERID SOURCE
PMC2386778 NLM
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