Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
18423837
TITLE
Quantifying the heritability of task-related brain activation and performance during the N-back working memory task: a twin fMRI study.
ABSTRACT
Working memory-related brain activation has been widely studied, and impaired activation patterns have been reported for several psychiatric disorders. We investigated whether variation in N-back working memory brain activation is genetically influenced in 60 pairs of twins, (29 monozygotic (MZ), 31 dizygotic (DZ); mean age 24.4+/-1.7S.D.). Task-related brain response (BOLD percent signal difference of 2 minus 0-back) was measured in three regions of interest. Although statistical power was low due to the small sample size, for middle frontal gyrus, angular gyrus, and supramarginal gyrus, the MZ correlations were, in general, approximately twice those of the DZ pairs, with non-significant heritability estimates (14-30%) in the low-moderate range. Task performance was strongly influenced by genes (57-73%) and highly correlated with cognitive ability (0.44-0.55). This study, which will be expanded over the next 3 years, provides the first support that individual variation in working memory-related brain activation is to some extent influenced by genes.
DATE PUBLISHED
2008 Sep
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2008/01/14
revised 2008/03/06
accepted 2008/03/12
aheadofprint 2008/03/16
pubmed 2008/04/22 09:00
medline 2008/10/24 09:00
entrez 2008/04/22 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Blokland GA Blokland Gabriëlla A M GA Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia.
McMahon KL McMahon Katie L KL
Hoffman J Hoffman Jan J
Zhu G Zhu Gu G
Meredith M Meredith Matthew M
Martin NG Martin Nicholas G NG
Thompson PM Thompson Paul M PM
de Zubicaray GI de Zubicaray Greig I GI
Wright MJ Wright Margaret J MJ
INVESTIGATORS
JOURNAL
VOLUME: 79
ISSUE: 1
TITLE: Biological psychology
ISOABBREVIATION: Biol Psychol
YEAR: 2008
MONTH: Sep
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0301-0511
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Biol Psychol
COUNTRY: Netherlands
ISSNLINKING: 0301-0511
NLMUNIQUEID: 0375566
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
R01 HD050735 NICHD NIH HHS United States
R01 HD050735-01A2 NICHD NIH HHS United States
R01HD050735 NICHD NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Brain physiology
Brain Chemistry genetics
Female genetics
Humans genetics
Image Processing, Computer-Assisted genetics
Individuality genetics
Magnetic Resonance Imaging genetics
Male genetics
Memory, Short-Term physiology
Models, Genetic physiology
Models, Statistical physiology
Oxygen blood
Phenotype blood
Psychomotor Performance physiology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
S88TT14065 Oxygen
OTHER ID's
OTHERID SOURCE
NIHMS46110 NLM
PMC2562930 NLM
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