Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
18418779
TITLE
Correlates of cigarette smoking during pregnancy and its genetic and environmental overlap with nicotine dependence.
ABSTRACT
Cigarette smoking during pregnancy (CSDP) is associated with a number of negative outcomes in the offspring. Therefore, clarifying the correlates of CSDP and the extent to which CSDP is associated with nicotine dependence is an important step toward reducing its rate in the general population. Using data from 1,134 adult Australian female monozygotic and dizygotic twin pairs, we explored the associations between CSDP and sociodemographic and psychiatric correlates and between CSDP and patterns of cigarette smoking. Further, we examined the role of heritable and environmental influences on CSDP and investigated whether these latent risk factors are shared with a predisposition to nicotine dependence. Women smoking during an entire pregnancy reported heavier dependence and more unsuccessful quit attempts, compared with the community sample of mothers and with women who smoked during only part of a pregnancy. Educational attainment, weekly church attendance, spousal current smoking, and nicotine dependence also were associated with CSDP. Heritable influences explained 34% of the variation in CSDP, with the remainder related to nonshared environmental factors. A large proportion of the genetic influences on CSDP were shared with DSM-III-R nicotine dependence, with little overlap across the nonshared environmental influences. A lifetime history of difficulty with smoking cessation, in conjunction with social background and psychiatric comorbidity, especially during pregnancy, needs to be considered by treatment providers when counseling expectant mothers about the potential risks of CSDP.
DATE PUBLISHED
2008 Apr
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2008/04/18 09:00
medline 2008/08/06 09:00
entrez 2008/04/18 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Agrawal A Agrawal Arpana A Washington University School of Medicine, Department of Psychiatry, St. Louis, MO 63110, USA. arpana@wustl.edu
Knopik VS Knopik Valerie S VS
Pergadia ML Pergadia Michele L ML
Waldron M Waldron Mary M
Bucholz KK Bucholz Kathleen K KK
Martin NG Martin Nicholas G NG
Heath AC Heath Andrew C AC
Madden PA Madden Pamela A F PA
INVESTIGATORS
JOURNAL
VOLUME: 10
ISSUE: 4
TITLE: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
ISOABBREVIATION: Nicotine Tob. Res.
YEAR: 2008
MONTH: Apr
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1462-2203
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Nicotine Tob Res
COUNTRY: England
ISSNLINKING: 1462-2203
NLMUNIQUEID: 9815751
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AA015210 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
AA13321 NIAAA NIH HHS United States
DA019951 NIDA NIH HHS United States
DA023668 NIDA NIH HHS United States
DA12854 NIDA NIH HHS United States
DA17671 NIDA NIH HHS United States
K01 DA017671 NIDA NIH HHS United States
K08 DA019951 NIDA NIH HHS United States
K08 DA019951-03 NIDA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Australia epidemiology
Female epidemiology
Health Behavior epidemiology
Humans epidemiology
Maternal Behavior epidemiology
Pregnancy epidemiology
Pregnancy Complications epidemiology
Questionnaires epidemiology
Risk Factors epidemiology
Smoking genetics
Smoking Cessation statistics & numerical data
Social Environment statistics & numerical data
Socioeconomic Factors statistics & numerical data
Substance Withdrawal Syndrome genetics
Twins genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's