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PMID |
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TITLE |
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The Queensland Study of Melanoma: environmental and genetic associations (Q-MEGA); study design, baseline characteristics, and repeatability of phenotype and sun exposure measures. |
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ABSTRACT |
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Cutaneous malignant melanoma (CMM) is a major health issue in Queensland, Australia, which has the world's highest incidence. Recent molecular and epidemiologic studies suggest that CMM arises through multiple etiological pathways involving gene-environment interactions. Understanding the potential mechanisms leading to CMM requires larger studies than those previously conducted. This article describes the design and baseline characteristics of Q-MEGA, the Queensland Study of Melanoma: Environmental and Genetic Associations, which followed up 4 population-based samples of CMM patients in Queensland, including children, adolescents, men aged over 50, and a large sample of adult cases and their families, including twins. Q-MEGA aims to investigate the roles of genetic and environmental factors, and their interaction, in the etiology of melanoma. Three thousand, four hundred and seventy-one participants took part in the follow-up study and were administered a computer-assisted telephone interview in 2002-2005. Updated data on environmental and phenotypic risk factors, and 2777 blood samples were collected from interviewed participants as well as a subset of relatives. This study provides a large and well-described population-based sample of CMM cases with follow-up data. Characteristics of the cases and repeatability of sun exposure and phenotype measures between the baseline and the follow-up surveys, from 6 to 17 years later, are also described. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
pubmed |
2008/03/26 09:00 |
medline |
2008/09/05 09:00 |
entrez |
2008/03/26 09:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Baxter AJ |
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Baxter |
Amanda J |
AJ |
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Queensland Institute of Medical Research, Brisbane, Queensland, Australia. |
Hughes MC |
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Hughes |
Maria Celia |
MC |
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Kvaskoff M |
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Kvaskoff |
Marina |
M |
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Siskind V |
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Siskind |
Victor |
V |
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Shekar S |
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Shekar |
Sri |
S |
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Aitken JF |
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Aitken |
Joanne F |
JF |
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Green AC |
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Green |
Adele C |
AC |
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Duffy DL |
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Duffy |
David L |
DL |
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Hayward NK |
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Hayward |
Nicholas K |
NK |
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Martin NG |
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Martin |
Nicholas G |
NG |
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Whiteman DC |
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Whiteman |
David C |
DC |
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INVESTIGATORS |
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JOURNAL |
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VOLUME: 11 |
ISSUE: 2 |
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies |
ISOABBREVIATION: Twin Res Hum Genet |
YEAR: 2008 |
MONTH: Apr |
DAY: |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Print |
ISSN: 1832-4274 |
ISSNTYPE: Print |
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MEDLINE JOURNAL |
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MEDLINETA: Twin Res Hum Genet |
COUNTRY: England |
ISSNLINKING: 1832-4274 |
NLMUNIQUEID: 101244624 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
Journal Article |
Research Support, N.I.H., Extramural |
Research Support, Non-U.S. Gov't |
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COMMENTS AND CORRECTIONS |
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REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
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GRANTS |
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GRANTID |
AGENCY |
COUNTRY |
CA88363 |
NCI NIH HHS |
United States |
R01 CA088363 |
NCI NIH HHS |
United States |
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GENERAL NOTE |
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KEYWORDS |
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MESH HEADINGS |
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DESCRIPTORNAME |
QUALIFIERNAME |
Adolescent |
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Adult |
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Aged |
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Child |
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Data Interpretation, Statistical |
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Female |
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Genetic Predisposition to Disease |
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Humans |
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Incidence |
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Male |
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Melanoma |
genetics |
Middle Aged |
genetics |
Queensland |
epidemiology |
Questionnaires |
epidemiology |
Reproducibility of Results |
epidemiology |
Research Design |
epidemiology |
Risk Factors |
epidemiology |
Skin Neoplasms |
genetics |
Sunlight |
adverse effects |
Twin Studies as Topic |
adverse effects |
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SUPPLEMENTARY MESH |
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GENE SYMBOLS |
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CHEMICALS |
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OTHER ID's |
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OTHERID |
SOURCE |
NIHMS468849 |
NLM |
PMC3677021 |
NLM |
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