|
|
| PMID |
|
|
| TITLE |
|
| The Queensland Study of Melanoma: environmental and genetic associations (Q-MEGA); study design, baseline characteristics, and repeatability of phenotype and sun exposure measures. |
|
| ABSTRACT |
|
|
|
| Cutaneous malignant melanoma (CMM) is a major health issue in Queensland, Australia, which has the world's highest incidence. Recent molecular and epidemiologic studies suggest that CMM arises through multiple etiological pathways involving gene-environment interactions. Understanding the potential mechanisms leading to CMM requires larger studies than those previously conducted. This article describes the design and baseline characteristics of Q-MEGA, the Queensland Study of Melanoma: Environmental and Genetic Associations, which followed up 4 population-based samples of CMM patients in Queensland, including children, adolescents, men aged over 50, and a large sample of adult cases and their families, including twins. Q-MEGA aims to investigate the roles of genetic and environmental factors, and their interaction, in the etiology of melanoma. Three thousand, four hundred and seventy-one participants took part in the follow-up study and were administered a computer-assisted telephone interview in 2002-2005. Updated data on environmental and phenotypic risk factors, and 2777 blood samples were collected from interviewed participants as well as a subset of relatives. This study provides a large and well-described population-based sample of CMM cases with follow-up data. Characteristics of the cases and repeatability of sun exposure and phenotype measures between the baseline and the follow-up surveys, from 6 to 17 years later, are also described. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2008/03/26 09:00 |
| medline |
2008/09/05 09:00 |
| entrez |
2008/03/26 09:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Baxter AJ |
|
Baxter |
Amanda J |
AJ |
|
Queensland Institute of Medical Research, Brisbane, Queensland, Australia. |
| Hughes MC |
|
Hughes |
Maria Celia |
MC |
|
|
| Kvaskoff M |
|
Kvaskoff |
Marina |
M |
|
|
| Siskind V |
|
Siskind |
Victor |
V |
|
|
| Shekar S |
|
Shekar |
Sri |
S |
|
|
| Aitken JF |
|
Aitken |
Joanne F |
JF |
|
|
| Green AC |
|
Green |
Adele C |
AC |
|
|
| Duffy DL |
|
Duffy |
David L |
DL |
|
|
| Hayward NK |
|
Hayward |
Nicholas K |
NK |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
| Whiteman DC |
|
Whiteman |
David C |
DC |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 11 |
| ISSUE: 2 |
| TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res Hum Genet |
| YEAR: 2008 |
| MONTH: Apr |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1832-4274 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Twin Res Hum Genet |
| COUNTRY: England |
| ISSNLINKING: 1832-4274 |
| NLMUNIQUEID: 101244624 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
| Cites |
Oncogene. 2003 May 19;22(20):3042-52 |
12789279 |
|
| Cites |
Oncogene. 2003 May 19;22(20):3053-62 |
12789280 |
|
| Cites |
Cancer Detect Prev. 2003;27(4):311-5 |
12893080 |
|
| Cites |
J Natl Cancer Inst. 2003 Dec 3;95(23):1801; author reply 1801-2 |
14652244 |
|
| Cites |
J Natl Cancer Inst. 2003 Dec 17;95(24):1878-90 |
14679157 |
|
| Cites |
Lancet. 2004 Feb 28;363(9410):728-30 |
15005091 |
|
| Cites |
Biometrics. 1977 Mar;33(1):159-74 |
843571 |
|
| Cites |
Am J Epidemiol. 1991 Feb 1;133(3):240-5 |
2000841 |
|
| Cites |
J Invest Dermatol. 1994 May;102(5):700-5 |
8176251 |
|
| Cites |
Am J Epidemiol. 1995 Jun 1;141(11):1033-7 |
7771439 |
|
| Cites |
Int J Cancer. 1995 Dec 11;63(6):765-8 |
8847130 |
|
| Cites |
Stat Methods Med Res. 1995 Dec;4(4):339-58 |
8745130 |
|
| Cites |
Melanoma Res. 1996 Apr;6(2):155-65 |
8791274 |
|
| Cites |
Int J Epidemiol. 1996 Apr;25(2):245-51 |
9119548 |
|
| Cites |
Int J Cancer. 1997 Jan 6;70(1):26-31 |
8985086 |
|
| Cites |
Ann Epidemiol. 1997 Feb;7(2):154-64 |
9099403 |
|
| Cites |
Int J Epidemiol. 1997 Aug;26(4):855-9 |
9279619 |
|
| Cites |
Int J Cancer. 1998 Sep 11;77(6):843-8 |
9714052 |
|
| Cites |
Int J Cancer. 1998 Sep 25;78(1):8-12 |
9724086 |
|
| Cites |
Cancer Epidemiol Biomarkers Prev. 1998 Oct;7(10):857-63 |
9796629 |
|
| Cites |
J Natl Cancer Inst. 1999 Mar 3;91(5):446-52 |
10070944 |
|
| Cites |
Eur J Cancer. 2005 Jan;41(1):45-60 |
15617990 |
|
| Cites |
J Clin Epidemiol. 2005 Apr;58(4):430-2 |
15862730 |
|
| Cites |
Eur J Cancer. 2005 Sep;41(14):2040-59 |
16125929 |
|
| Cites |
N Engl J Med. 2005 Nov 17;353(20):2135-47 |
16291983 |
|
| Cites |
Cancer Epidemiol Biomarkers Prev. 2006 Aug;15(8):1538-44 |
16896046 |
|
| Cites |
Cancer Epidemiol Biomarkers Prev. 2006 Nov;15(11):2292-7 |
17119060 |
|
| Cites |
J Eur Acad Dermatol Venereol. 2007 Sep;21(8):1071-3 |
17714127 |
|
| Cites |
Stat Methods Med Res. 2000 Oct;9(5):447-74 |
11191260 |
|
| Cites |
Int J Cancer. 2002 Mar 1;98(1):92-8 |
11857391 |
|
| Cites |
Int J Epidemiol. 2002 Apr;31(2):439-46 |
11980813 |
|
| Cites |
J Natl Cancer Inst. 2003 Jun 4;95(11):806-12 |
12783935 |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| CA88363 |
NCI NIH HHS |
United States |
| R01 CA088363 |
NCI NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Adult |
|
| Aged |
|
| Child |
|
| Data Interpretation, Statistical |
|
| Female |
|
| Genetic Predisposition to Disease |
|
| Humans |
|
| Incidence |
|
| Male |
|
| Melanoma |
genetics |
| Middle Aged |
genetics |
| Queensland |
epidemiology |
| Questionnaires |
epidemiology |
| Reproducibility of Results |
epidemiology |
| Research Design |
epidemiology |
| Risk Factors |
epidemiology |
| Skin Neoplasms |
genetics |
| Sunlight |
adverse effects |
| Twin Studies as Topic |
adverse effects |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
| OTHERID |
SOURCE |
| NIHMS468849 |
NLM |
| PMC3677021 |
NLM |
|
|
