Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
18286631
TITLE
Externalizing disorders in American Indians: comorbidity and a genome wide linkage analysis.
ABSTRACT
Alcohol dependence is one of the leading causes of morbidity and mortality in Native Americans. Externalizing disorders such as conduct disorder (CD) and antisocial personality disorder (ASPD) have been demonstrated to have significant comorbidity with alcohol dependence in the general population. This study's aims were to: assess the comorbidity of DSM-III-R ASPD and CD with alcohol dependence, to map susceptibility loci for ASPD and CD, and to see if there is overlap with loci previously mapped for alcohol dependence phenotypes in 587 American Indians. Alcohol dependence was found to be comorbid with DSM-III-R ASPD but not CD. However, the amount of alcohol dependence in the population attributable to ASPD and/or CD is low. ASPD and the combined phenotype of participants with ASPD or CD were both found to have significant heritability, whereas no significant evidence was found for CD alone. Genotypes were determined for a panel of 791 micro-satellite polymorphisms in 251 of the participants. Analyses of multipoint variance component LOD scores, for ASPD and ASPD/CD, revealed six locations that had a LOD score of 2.0 or above: on chromosome 13 for ASPD and on chromosomes 1, 3, 4, 14, 17, and 20 for ASPD/CD. These results corroborate the importance of several chromosomal regions highlighted in prior segregation studies for externalizing diagnoses. These results also further identify new regions of the genome, that do not overlap with alcohol dependence phenotypes previously identified in this population, that may be unique to either the phenotypes evaluated or this population of American Indians.
2008 Wiley-Liss, Inc.
DATE PUBLISHED
2008 Sep 5
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2008/02/21 09:00
medline 2008/12/17 09:00
entrez 2008/02/21 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Ehlers CL Ehlers Cindy L CL Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA. cindye@scripps.edu
Gilder DA Gilder David A DA
Slutske WS Slutske Wendy S WS
Lind PA Lind Penelope A PA
Wilhelmsen KC Wilhelmsen Kirk C KC
INVESTIGATORS
JOURNAL
VOLUME: 147B
ISSUE: 6
TITLE: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
ISOABBREVIATION: Am. J. Med. Genet. B Neuropsychiatr. Genet.
YEAR: 2008
MONTH: Sep
DAY: 5
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1552-485X
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Am J Med Genet B Neuropsychiatr Genet
COUNTRY: United States
ISSNLINKING: 1552-4841
NLMUNIQUEID: 101235742
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Alcohol Alcohol. 1997 Mar-Apr;32(2):129-32 9105506
Cites Arch Gen Psychiatry. 1997 Apr;54(4):313-21 9107147
Cites Am J Psychiatry. 1997 Jul;154(7):983-8 9210750
Cites Psychol Med. 1997 Nov;27(6):1381-96 9403910
Cites Genet Epidemiol. 1997;14(6):953-8 9433606
Cites J Stud Alcohol. 1998 Mar;59(2):222-6 9500310
Cites Behav Genet. 2005 Mar;35(2):115-20 15685425
Cites Atherosclerosis. 2005 Mar;179(1):119-25 15721017
Cites Psychiatr Genet. 2005 Mar;15(1):71-5 15722961
Cites Am J Drug Alcohol Abuse. 2005;31(1):93-110 15768573
Cites Psychiatr Genet. 2005 Jun;15(2):101-7 15900224
Cites J Clin Psychiatry. 2005 Jun;66(6):677-85 15960559
Cites Am J Psychiatry. 2005 Sep;162(9):1723-32 16135633
Cites Arch Gen Psychiatry. 2005 Sep;62(9):1042-51 16143736
Cites BMC Med Genet. 2006;7:9 16472381
Cites Twin Res Hum Genet. 2006 Feb;9(1):38-45 16611466
Cites J Subst Abuse Treat. 2006 Jun;30(4):275-84 16716841
Cites Behav Genet. 2006 Jul;36(4):591-602 16557361
Cites Behav Genet. 2006 Jul;36(4):577-90 16557364
Cites Addict Biol. 2006 Sep;11(3-4):374-85 16961765
Cites J Nerv Ment Dis. 2006 Sep;194(9):667-75 16971818
Cites Alcohol Clin Exp Res. 2006 Nov;30(11):1856-65 17067349
Cites Alcohol Clin Exp Res. 2006 Dec;30(12):1972-7 17117961
Cites J Affect Disord. 2007 Apr;99(1-3):265-71 16978706
Cites Genes Brain Behav. 2007 Mar;6(2):184-91 16764678
Cites Neuropsychopharmacology. 1998 Apr;18(4):282-92 9509496
Cites Psychiatr Serv. 1998 Mar;49(3):345-50 9525794
Cites Am J Hum Genet. 1998 May;62(5):1198-211 9545414
Cites Alcohol Clin Exp Res. 1998 Apr;22(2):518-23 9581662
Cites Am J Med Genet. 1998 May 8;81(3):216-21 9603607
Cites J Am Acad Child Adolesc Psychiatry. 1998 Jul;37(7):736-42 9666629
Cites J Am Acad Child Adolesc Psychiatry. 1998 Aug;37(8):866-73 9695449
Cites J Abnorm Psychol. 1998 Aug;107(3):363-74 9715572
Cites Child Abuse Negl. 1998 Nov;22(11):1079-91 9827313
Cites Am Indian Alsk Native Ment Health Res. 1998;8(2):24-45 9842064
Cites Am J Psychiatry. 1999 Jan;156(1):34-40 9892295
Cites J Stud Alcohol. 1999 Mar;60(2):159-67 10091952
Cites Biol Psychiatry. 1999 Mar 15;45(6):776-87 10188009
Cites Soc Psychiatry Psychiatr Epidemiol. 1999 Apr;34(4):180-9 10365623
Cites Psychiatr Clin North Am. 1999 Jun;22(2):221-40 10385930
Cites Alcohol. 1999 Aug;19(1):97-9 10487393
Cites CNS Drugs. 2004;18(15):1105-18 15581381
Cites Alcohol Clin Exp Res. 2004 Oct;28(10):1481-6 15597079
Cites Alcohol Clin Exp Res. 2004 Dec;28(12):1805-13 15608596
Cites Drug Alcohol Depend. 2005 Jan 7;77(1):13-21 15607837
Cites Addiction. 1999 Sep;94(9):1361-70 10615721
Cites Dev Psychopathol. 1999 Fall;11(4):727-44 10624723
Cites J Stud Alcohol. 2000 Jan;61(1):150-6 10627109
Cites Clin Psychol Rev. 2000 Mar;20(2):255-87 10721500
Cites Am J Psychiatry. 2000 May;157(5):745-50 10784467
Cites Am J Addict. 2000 Spring;9(2):113-25 10934573
Cites Genet Epidemiol. 2000;19 Suppl 1:S8-14 11055364
Cites Curr Psychiatry Rep. 2001 Apr;3(2):158-62 11276412
Cites Psychiatry Res. 2001 Dec 15;105(1-2):67-78 11740976
Cites J Abnorm Psychol. 2002 Feb;111(1):124-33 11871377
Cites Public Health Rep. 2001;116 Suppl 1:216-22 11889287
Cites Dev Psychopathol. 2002 Spring;14(2):395-416 12030698
Cites Arch Gen Psychiatry. 2002 Aug;59(8):750-7 12150652
Cites Arch Gen Psychiatry. 2002 Dec;59(12):1125-32 12470129
Cites Am J Drug Alcohol Abuse. 2002 Nov;28(4):643-52 12492261
Cites Am J Psychiatry. 2003 Jan;160(1):41-6 12505800
Cites J Psychoactive Drugs. 2003 Jan-Mar;35(1):7-13 12733753
Cites J Psychoactive Drugs. 2003 Jan-Mar;35(1):79-84 12733762
Cites Drug Alcohol Depend. 2003 Jun 5;70(3):295-307 12757967
Cites Alcohol Clin Exp Res. 2003 Jul;27(7):1041-7 12878909
Cites Arch Gen Psychiatry. 2003 Sep;60(9):929-37 12963675
Cites Alcohol Clin Exp Res. 2003 Aug;27(8):1368-73 12966342
Cites JAMA. 2003 Oct 15;290(15):2023-9 14559956
Cites Mol Psychiatry. 2004 Jan;9(1):81-6 14699444
Cites Am J Psychiatry. 2004 Jul;161(7):1204-10 15229052
Cites Am J Med Genet B Neuropsychiatr Genet. 2004 Aug 15;129B(1):110-5 15274051
Cites J Stud Alcohol. 2004 Jul;65(4):409-18 15376814
Cites Arch Gen Psychiatry. 1981 Aug;38(8):861-8 7259422
Cites JAMA. 1985 Nov 8;254(18):2614-7 4057470
Cites Am J Hum Genet. 1989 Mar;44(3):388-96 2916582
Cites Biol Psychiatry. 1990 Jun 15;27(12):1293-304 2364118
Cites JAMA. 1990 Nov 21;264(19):2511-8 2232018
Cites J Nerv Ment Dis. 1992 Jan;180(1):33-9 1538204
Cites JAMA. 1992 Oct 14;268(14):1877-82 1404711
Cites Cult Med Psychiatry. 1992-1993;16(4):471-86 1305527
Cites Compr Psychiatry. 1993 Jul-Aug;34(4):235-42 8348801
Cites Arch Gen Psychiatry. 1994 Jan;51(1):8-19 8279933
Cites Public Health Rep. 1994 Mar-Apr;109(2):235-42 8153275
Cites J Stud Alcohol. 1994 Mar;55(2):149-58 8189735
Cites Science. 1994 Sep 30;265(5181):2037-48 8091226
Cites Arch Gen Psychiatry. 1995 Nov;52(11):906-15 7487339
Cites Am J Hum Genet. 1996 Jun;58(6):1347-63 8651312
Cites Subst Use Misuse. 1996 Apr;31(5):581-98 8777740
Cites Alcohol Alcohol Suppl. 1994;2:479-84 8974371
GRANTS
GRANTID AGENCY COUNTRY
AA010201 NIAAA NIH HHS United States
DA019333 NIDA NIH HHS United States
R01 AA010201 NIAAA NIH HHS United States
R01 AA010201-11A1 NIAAA NIH HHS United States
R01 DA019333 NIDA NIH HHS United States
R01 DA019333-04 NIDA NIH HHS United States
R37 AA010201 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Acting Out
Adolescent
Adult
Aged
Chromosome Mapping
Comorbidity
Family Health
Female
Gene Frequency
Genetic Linkage
Genome, Human
Humans
Indians, North American statistics & numerical data
Male statistics & numerical data
Mental Disorders genetics
Middle Aged genetics
Prevalence genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS180917 NLM
PMC2839892 NLM
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