Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
18286631
TITLE
Externalizing disorders in American Indians: comorbidity and a genome wide linkage analysis.
ABSTRACT
Alcohol dependence is one of the leading causes of morbidity and mortality in Native Americans. Externalizing disorders such as conduct disorder (CD) and antisocial personality disorder (ASPD) have been demonstrated to have significant comorbidity with alcohol dependence in the general population. This study's aims were to: assess the comorbidity of DSM-III-R ASPD and CD with alcohol dependence, to map susceptibility loci for ASPD and CD, and to see if there is overlap with loci previously mapped for alcohol dependence phenotypes in 587 American Indians. Alcohol dependence was found to be comorbid with DSM-III-R ASPD but not CD. However, the amount of alcohol dependence in the population attributable to ASPD and/or CD is low. ASPD and the combined phenotype of participants with ASPD or CD were both found to have significant heritability, whereas no significant evidence was found for CD alone. Genotypes were determined for a panel of 791 micro-satellite polymorphisms in 251 of the participants. Analyses of multipoint variance component LOD scores, for ASPD and ASPD/CD, revealed six locations that had a LOD score of 2.0 or above: on chromosome 13 for ASPD and on chromosomes 1, 3, 4, 14, 17, and 20 for ASPD/CD. These results corroborate the importance of several chromosomal regions highlighted in prior segregation studies for externalizing diagnoses. These results also further identify new regions of the genome, that do not overlap with alcohol dependence phenotypes previously identified in this population, that may be unique to either the phenotypes evaluated or this population of American Indians.
2008 Wiley-Liss, Inc.
DATE PUBLISHED
2008 Sep 5
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2008/02/21 09:00
medline 2008/12/17 09:00
entrez 2008/02/21 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Ehlers CL Ehlers Cindy L CL Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA. cindye@scripps.edu
Gilder DA Gilder David A DA
Slutske WS Slutske Wendy S WS
Lind PA Lind Penelope A PA
Wilhelmsen KC Wilhelmsen Kirk C KC
INVESTIGATORS
JOURNAL
VOLUME: 147B
ISSUE: 6
TITLE: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
ISOABBREVIATION: Am. J. Med. Genet. B Neuropsychiatr. Genet.
YEAR: 2008
MONTH: Sep
DAY: 5
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1552-485X
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Am J Med Genet B Neuropsychiatr Genet
COUNTRY: United States
ISSNLINKING: 1552-4841
NLMUNIQUEID: 101235742
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
AA010201 NIAAA NIH HHS United States
DA019333 NIDA NIH HHS United States
R01 AA010201 NIAAA NIH HHS United States
R01 AA010201-11A1 NIAAA NIH HHS United States
R01 DA019333 NIDA NIH HHS United States
R01 DA019333-04 NIDA NIH HHS United States
R37 AA010201 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Acting Out
Adolescent
Adult
Aged
Chromosome Mapping
Comorbidity
Family Health
Female
Gene Frequency
Genetic Linkage
Genome, Human
Humans
Indians, North American statistics & numerical data
Male statistics & numerical data
Mental Disorders genetics
Middle Aged genetics
Prevalence genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS180917 NLM
PMC2839892 NLM