Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
18226290
TITLE
Shared and unique risk factors between lifetime purging and objective binge eating: a twin study.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Objective binge eating (OBE) and self-induced vomiting (SIV) occur and co-occur across a range of eating disorders but the extent to which the risk factors for these two behaviours overlap is unclear. Examination of this overlap was the focus of the current report.
METHOD NlmCategory: METHODS
A population of female Australian twins (n=1002), mean age 35 years (s.d.=2.11, range 28-40), participated in three waves of data collection and were assessed for lifetime disordered eating with a semi-structured interview at wave 3 and a self-report questionnaire at wave 1; risk factors were assessed via a self-report at waves 1 and 3.
RESULTS NlmCategory: RESULTS
Non-shared environmental influences were the largest contributor to the variance of both OBE and SIV, with a more modest contribution of genetic influences. Between 5% and 14% of the environmental risk factors for OBE and SIV were shared and 27-100% of genetic risk factors were shared. SIV initiation was predicted by higher neuroticism and novelty seeking and lower maternal and paternal care, whilst lower levels of perceived paternal care, higher lifetime BMI, and a wider BMI range predicted OBE initiation. Retrospective correlates associated with both SIV and OBE onset were parental comments about weight, whilst higher levels of parental conflict, expectations and criticism was associated with OBE onset only.
CONCLUSIONS NlmCategory: CONCLUSIONS
The substantial extent of non-overlap between risk factors for SIV and OBE suggests that each of these behavioural disturbances warrants future investigation in its own right, not only when they occur in conjunction with each other.
DATE PUBLISHED
2008 Oct
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2008/01/29
pubmed 2008/01/30 09:00
medline 2009/01/07 09:00
entrez 2008/01/30 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Wade TD Wade T D TD School of Psychology, Flinders University, South Australia, Australia. tracey.wade@flinders.edu.au
Treloar S Treloar S S
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 38
ISSUE: 10
TITLE: Psychological medicine
ISOABBREVIATION: Psychol Med
YEAR: 2008
MONTH: Oct
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0033-2917
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Psychol Med
COUNTRY: England
ISSNLINKING: 0033-2917
NLMUNIQUEID: 1254142
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Bulimia Nervosa psychology
Comorbidity psychology
Diagnostic and Statistical Manual of Mental Disorders psychology
Female psychology
Humans psychology
Interviews as Topic psychology
Parent-Child Relations psychology
Prevalence psychology
Prospective Studies psychology
Questionnaires psychology
Risk Factors psychology
Twins psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's