Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
18193478
TITLE
Childhood sexual abuse moderates genetic influences on age at first consensual sexual intercourse in women.
ABSTRACT
We examine interactive effects of childhood sexual abuse (CSA) on heritable variation in age at first consensual sexual intercourse in a young cohort of 3,350 female and 2,724 male Australian twins. Consistent with hypotheses, genetic influences explained little if any variation in age at first consensual sexual intercourse for female twins reporting CSA (CSA(+)), with shared environment explaining 73%. For female twins reporting no history of CSA (CSA(-)), 39% of variation in age at first consensual sexual intercourse was explained by genetic effects, with shared environment accounting for 30%. For male twins, significant interactive effects of CSA on genetic and environmental variation in age at first consensual sexual intercourse were not observed. Overall genetic influences explained 51% of variation in age at first consensual sexual intercourse for male twins, with shared environment accounting for 8%. For both female and male twins, results from models that included conduct disorder as a covariate were near identical to results from models without conduct disorder.
DATE PUBLISHED
2008 Jan
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2007/03/09
accepted 2007/10/12
aheadofprint 2007/11/01
pubmed 2008/01/15 09:00
medline 2008/07/02 09:00
entrez 2008/01/15 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Waldron M Waldron Mary M Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid, Campus Box 8134, St. Louis, MO 63110, USA. maryw@matlock.wustl.edu
Heath AC Heath Andrew C AC
Turkheimer EN Turkheimer Eric N EN
Emery RE Emery Robert E RE
Nelson E Nelson Elliot E
Bucholz KK Bucholz Kathleen K KK
Madden PA Madden Pamela A F PA
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 38
ISSUE: 1
TITLE: Behavior genetics
ISOABBREVIATION: Behav. Genet.
YEAR: 2008
MONTH: Jan
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0001-8244
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Behav Genet
COUNTRY: United States
ISSNLINKING: 0001-8244
NLMUNIQUEID: 0251711
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
AA015210 NIAAA NIH HHS United States
AA07535 NIAAA NIH HHS United States
AA07720 NIAAA NIH HHS United States
AA10242 NIAAA NIH HHS United States
AA1998 NIAAA NIH HHS United States
R01 HD053550 NICHD NIH HHS United States
R01 HD053550-01A1 NICHD NIH HHS United States
R01 HD056354 NICHD NIH HHS United States
R01 HD056354-01 NICHD NIH HHS United States
T32AA0750 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Analysis of Variance
Australia
Child
Child Abuse, Sexual statistics & numerical data
Cohort Studies statistics & numerical data
Coitus psychology
Female psychology
Genetics, Medical psychology
Humans psychology
Male psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS216244 NLM
PMC2905223 NLM
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