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| PMID |
|
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| TITLE |
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| Association between single nucleotide polymorphisms in the cannabinoid receptor gene (CNR1) and impulsivity in southwest California Indians. |
|
| ABSTRACT |
|
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| Impulsivity is a personality trait characterized by acting suddenly in an unplanned manner in order to satisfy a desire without consideration for the consequences of such behavior. There are several psychiatric disorders that include the term impulsivity as a criterion and, therefore, it has been suggested that impulsivity may be an important phenotype that may link a number of different behavioral disorders, including substance abuse. This study's aims were to determine if a significant association could be detected between the (AAT)n triplet repeat polymorphism as well as 5 single nucleotide polymorphisms (SNPs) in or near the CNR1 receptor gene and impulsivity in Southwest California 'Mission' Indians (SWC). Impulsivity was assessed using a scale derived from the Maudsley personality inventory, and blood samples were collected for DNA analyses from 251 individuals recruited from local Indian reservations. The estimated heritability (h(2)) for the impulsivity phenotype was 0.20 + 0.12 (p < .004). Impulsivity was significantly associated with the 6-repeat allele of the triplet repeat polymorphism (AATn/A6; p < .0001), as well as four SNPs in or near the CNR1 receptor gene: rs1535255 (p = .001), rs2023239 (p = .004), rs1049353 (p < .001) and rs806368 (p < .0006). These studies provide data to suggest that the CNR1 receptor gene may be significantly associated with impulsivity in SWC Indians. |
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| DATE PUBLISHED |
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| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2008/01/09 09:00 |
| medline |
2008/02/02 09:00 |
| entrez |
2008/01/09 09:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Ehlers CL |
|
Ehlers |
Cindy L |
CL |
|
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA. cindye@scripps.edu |
| Slutske WS |
|
Slutske |
Wendy S |
WS |
|
|
| Lind PA |
|
Lind |
Penelope A |
PA |
|
|
| Wilhelmsen KC |
|
Wilhelmsen |
K C |
KC |
|
|
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| INVESTIGATORS |
|
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| JOURNAL |
|
| VOLUME: 10 |
| ISSUE: 6 |
| TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res Hum Genet |
| YEAR: 2007 |
| MONTH: Dec |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1832-4274 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Twin Res Hum Genet |
| COUNTRY: England |
| ISSNLINKING: 1832-4274 |
| NLMUNIQUEID: 101244624 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
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| COMMENTS AND CORRECTIONS |
|
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| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| 5 R01 DA019333 |
NIDA NIH HHS |
United States |
| 5 R37 AA010201 |
NIAAA NIH HHS |
United States |
| R01 AA010201 |
NIAAA NIH HHS |
United States |
| R01 DA019333 |
NIDA NIH HHS |
United States |
|
| GENERAL NOTE |
|
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| KEYWORDS |
|
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| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Base Sequence |
|
| California |
|
| DNA Primers |
genetics |
| Female |
genetics |
| Humans |
genetics |
| Impulsive Behavior |
genetics |
| Indians, North American |
psychology |
| Linkage Disequilibrium |
psychology |
| Male |
psychology |
| Polymorphism, Single Nucleotide |
psychology |
| Receptor, Cannabinoid, CB1 |
genetics |
| Trinucleotide Repeats |
genetics |
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| SUPPLEMENTARY MESH |
|
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| GENE SYMBOLS |
|
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| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
DNA Primers |
| 0 |
Receptor, Cannabinoid, CB1 |
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| OTHER ID's |
|
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|
