Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
18053258
TITLE
The Lothian Birth Cohort 1936: a study to examine influences on cognitive ageing from age 11 to age 70 and beyond.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Cognitive ageing is a major burden for society and a major influence in lowering people's independence and quality of life. It is the most feared aspect of ageing. There are large individual differences in age-related cognitive changes. Seeking the determinants of cognitive ageing is a research priority. A limitation of many studies is the lack of a sufficiently long period between cognitive assessments to examine determinants. Here, the aim is to examine influences on cognitive ageing between childhood and old age.
METHODS/DESIGN NlmCategory: METHODS
The study is designed as a follow-up cohort study. The participants comprise surviving members of the Scottish Mental Survey of 1947 (SMS1947; N = 70,805) who reside in the Edinburgh area (Lothian) of Scotland. The SMS1947 applied a valid test of general intelligence to all children born in 1936 and attending Scottish schools in June 1947. A total of 1091 participants make up the Lothian Birth Cohort 1936. They undertook: a medical interview and examination; physical fitness testing; extensive cognitive testing (reasoning, memory, speed of information processing, and executive function); personality, quality of life and other psycho-social questionnaires; and a food frequency questionnaire. They have taken the same mental ability test (the Moray House Test No. 12) at age 11 and age 70. They provided blood samples for DNA extraction and testing and other biomarker analyses. Here we describe the background and aims of the study, the recruitment procedures and details of numbers tested, and the details of all examinations.
DISCUSSION NlmCategory: CONCLUSIONS
The principal strength of this cohort is the rarely captured phenotype of lifetime cognitive change. There is additional rich information to examine the determinants of individual differences in this lifetime cognitive change. This protocol report is important in alerting other researchers to the data available in the cohort.
DATE PUBLISHED
2007
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2007/11/15
accepted 2007/12/05
aheadofprint 2007/12/05
pubmed 2007/12/07 09:00
medline 2008/03/01 09:00
entrez 2007/12/07 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Deary IJ Deary Ian J IJ Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK. I.Deary@ed.ac.uk
Gow AJ Gow Alan J AJ
Taylor MD Taylor Michelle D MD
Corley J Corley Janie J
Brett C Brett Caroline C
Wilson V Wilson Valerie V
Campbell H Campbell Harry H
Whalley LJ Whalley Lawrence J LJ
Visscher PM Visscher Peter M PM
Porteous DJ Porteous David J DJ
Starr JM Starr John M JM
INVESTIGATORS
JOURNAL
VOLUME: 7
ISSUE:
TITLE: BMC geriatrics
ISOABBREVIATION: BMC Geriatr
YEAR: 2007
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1471-2318
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: BMC Geriatr
COUNTRY: England
ISSNLINKING: 1471-2318
NLMUNIQUEID: 100968548
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Review
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
G0701120 Medical Research Council United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Age Distribution
Aged
Aging physiology
Child physiology
Cognition physiology
Cognition Disorders epidemiology
Cohort Studies epidemiology
Female epidemiology
Follow-Up Studies epidemiology
Great Britain epidemiology
Humans epidemiology
Incidence epidemiology
Intelligence Tests epidemiology
Male epidemiology
Middle Aged epidemiology
Questionnaires epidemiology
Registries epidemiology
Risk Assessment epidemiology
Sex Distribution epidemiology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC2222601 NLM
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