Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
17969472
TITLE
"No thanks, it keeps me awake": the genetics of coffee-attributed sleep disturbance.
ABSTRACT
STUDY OBJECTIVES NlmCategory: OBJECTIVE
Previous genetic investigations of sleep disturbance have shown various measures of sleep quality and sleep pattern to be heritable. But none of these studies have investigated the genetic predisposition to sleep disturbance attributed to caffeine. In this study, the heritability of coffee-attributed sleep disturbance and its relationship with other sleep measures were estimated, and chromosomal regions influencing this trait were identified.
DESIGN NlmCategory: METHODS
A classical twin design was used to estimate the heritability of coffee-attributed sleep disturbance and its genetic covariance with other measures of sleep disturbance (e.g., due to anxiety, depression) and sleep quality (e.g., variability in sleep quality). To locate quantitative trait loci influencing coffee-attributed sleep disturbance, a genome-wide linkage screen of 1395 microsatellite markers was performed.
PARTICIPANTS NlmCategory: METHODS
The study included 3808 Australian adult twin pairs (n = 1799 monozygous pairs; n = 2009 dizygous pairs). A subsample of 1989 individuals from 1175 families was used for the linkage analysis.
MEASUREMENTS AND RESULTS NlmCategory: RESULTS
The heritability of coffee-attributed sleep disturbance (measured by self report) was approximately 0.40, with three fourths of this genetic variance explained by genes unrelated to the general sleep disturbance factor. One region of significant linkage to coffee-attributed sleep disturbance was identified on chromosome 2q (LOD score of 2.9).
CONCLUSIONS NlmCategory: CONCLUSIONS
Although no candidate genes known to be related to caffeine metabolism or sleep disorder were identified in the significant linkage region, 2 candidates were found under a smaller peak on chromosome 17q.
DATE PUBLISHED
2007 Oct
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2007/11/01 09:00
medline 2008/01/25 09:00
entrez 2007/11/01 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Luciano M Luciano Michelle M Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia. michelle.luciano@qimr.edu.au
Zhu G Zhu Ghu G
Kirk KM Kirk Katherine M KM
Gordon SD Gordon Scott D SD
Heath AC Heath Andrew C AC
Montgomery GW Montgomery Grant W GW
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 30
ISSUE: 10
TITLE: Sleep
ISOABBREVIATION: Sleep
YEAR: 2007
MONTH: Oct
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0161-8105
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Sleep
COUNTRY: United States
ISSNLINKING: 0161-8105
NLMUNIQUEID: 7809084
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Drug Alcohol Depend. 1999 Nov 1;57(1):69-78 10617315
Cites Am J Hum Genet. 2007 May;80(5):856-66 17436240
Cites Nat Genet. 2002 Jan;30(1):97-101 11731797
Cites Am J Hum Genet. 2002 Mar;70(3):652-62 11836652
Cites Annu Rev Neurosci. 2002;25:283-313 12052911
Cites Nature. 2002 Aug 15;418(6899):774-8 12181566
Cites Psychopharmacology (Berl). 2002 Nov;164(3):241-9 12424547
Cites Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1322-7 12538871
Cites Psychopharmacology (Berl). 2003 Apr;167(1):54-62 12601503
Cites Hum Psychopharmacol. 2004 Jul;19(5):333-41 15252825
Cites J Psychosom Res. 1968 Oct;12(3):199-203 5686042
Cites Br J Soc Clin Psychol. 1976 Nov;15(4):387-94 1000147
Cites Ann Hum Genet. 1975 Oct;39(2):213-8 1053248
Cites Clin Pharmacol Ther. 1983 Jun;33(6):770-5 6851408
Cites Sleep. 1983;6(3):179-85 6684786
Cites Sleep. 1990 Aug;13(4):318-35 2267475
Cites Arch Gen Psychiatry. 1991 Jul;48(7):611-7 2069491
Cites Sleep. 1991 Dec;14(6):540-5 1798888
Cites Sleep. 1994 Aug;17(5):456-61 7991958
Cites Genet Epidemiol. 1997;14(3):223-9 9181352
Cites Am J Hum Genet. 1998 Apr;62(4):994-7 9529350
Cites Am J Hum Genet. 1999 Jan;64(1):259-67 9915965
Cites Am J Psychiatry. 1999 Feb;156(2):223-8 9989558
Cites Twin Res. 1998 Dec;1(4):176-88 10100809
Cites Am J Hum Genet. 1999 Aug;65(2):483-92 10417291
Cites J Pharmacol Exp Ther. 1965 Jul;149:156-9 14334284
Cites Addiction. 2005 Oct;100(10):1510-7 16185212
Cites Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15676-81 16221767
Cites Twin Res Hum Genet. 2005 Dec;8(6):616-32 16363087
Cites JAMA. 2006 Mar 8;295(10):1135-41 16522833
Cites PLoS Genet. 2006 Mar;2(3):e41 16565746
Cites Nat Med. 2000 Sep;6(9):991-7 10973318
GRANTS
GRANTID AGENCY COUNTRY
AA007535 NIAAA NIH HHS United States
AA007728 NIAAA NIH HHS United States
AA013320 NIAAA NIH HHS United States
AA013321 NIAAA NIH HHS United States
AA013326 NIAAA NIH HHS United States
AA014041 NIAAA NIH HHS United States
AA10249 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Arousal drug effects
Australia epidemiology
Central Nervous System Stimulants adverse effects
Chromosomes, Human, Pair 7 adverse effects
Coffee adverse effects
Diseases in Twins genetics
Female genetics
Genetic Predisposition to Disease genetics
Humans genetics
Male genetics
Middle Aged genetics
Multivariate Analysis genetics
Questionnaires genetics
Sleep Initiation and Maintenance Disorders genetics
Sleep Stages genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Central Nervous System Stimulants
0 Coffee
OTHER ID's
OTHERID SOURCE
PMC2266272 NLM
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