|
|
| PMID |
|
|
| TITLE |
|
| Genetic dissection of myopia: evidence for linkage of ocular axial length to chromosome 5q. |
|
| ABSTRACT |
|
| PURPOSE |
NlmCategory: OBJECTIVE |
| To estimate heritability and locate quantitative trait loci influencing axial length. |
| DESIGN |
NlmCategory: METHODS |
| Classic twin study of monozygotic and dizygotic twins reared together. |
| PARTICIPANTS |
NlmCategory: METHODS |
| Eight hundred ninety-three individuals from 460 families were recruited through the Twin Eye Study in Tasmania and the Brisbane Adolescent Twin Study (BATS) and had ocular axial length measured. |
| METHODS |
NlmCategory: METHODS |
| Structural equation modeling on the entire sample was used to estimate genetic and environmental components of variation in axial length. Analysis of existing microsatellite marker genomewide linkage scan data was performed on 318 individuals from 142 BATS families. |
| MAIN OUTCOME MEASURE |
NlmCategory: METHODS |
| Ocular axial length. |
| RESULTS |
NlmCategory: RESULTS |
| The heritability estimate for axial length, adjusted for age and sex, in the full sample was 0.81. The highest multipoint logarithm of the odds (LOD) score observed was 3.40 (genomewide P = 0.0004), on chromosome 5q (at 98 centimorgans [cM]). Additional regions with suggestive multipoint LOD scores were also identified on chromosome 6 (LOD scores, 2.13 at 76 cM and 2.05 at 83 cM), chromosome 10 (LOD score, 2.03 at 131 cM), and chromosome 14 (LOD score, 2.84 at 97 cM). |
| CONCLUSION |
NlmCategory: CONCLUSIONS |
| Axial length, a major endophenotype for refractive error, is highly heritable and is likely to be influenced by one or more genes on the long arm of chromosome 5. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2007/04/10 |
| revised |
2007/08/07 |
| accepted |
2007/08/09 |
| aheadofprint |
2007/10/26 |
| pubmed |
2007/10/30 09:00 |
| medline |
2008/06/13 09:00 |
| entrez |
2007/10/30 09:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Zhu G |
|
Zhu |
Gu |
G |
|
Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia. D.Mackey@utas.edu.au |
| Hewitt AW |
|
Hewitt |
Alex W |
AW |
|
|
| Ruddle JB |
|
Ruddle |
Jonathan B |
JB |
|
|
| Kearns LS |
|
Kearns |
Lisa S |
LS |
|
|
| Brown SA |
|
Brown |
Shayne A |
SA |
|
|
| Mackinnon JR |
|
Mackinnon |
Jane R |
JR |
|
|
| Chen CY |
|
Chen |
Christine Y |
CY |
|
|
| Hammond CJ |
|
Hammond |
Christopher J |
CJ |
|
|
| Craig JE |
|
Craig |
Jamie E |
JE |
|
|
| Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
| Mackey DA |
|
Mackey |
David A |
DA |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 115 |
| ISSUE: 6 |
| TITLE: Ophthalmology |
| ISOABBREVIATION: Ophthalmology |
| YEAR: 2008 |
| MONTH: Jun |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1549-4713 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Ophthalmology |
| COUNTRY: United States |
| ISSNLINKING: 0161-6420 |
| NLMUNIQUEID: 7802443 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| CA88363 |
NCI NIH HHS |
United States |
| N01-HG-65403 |
NHGRI NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Adult |
|
| Aged |
|
| Aged, 80 and over |
|
| Child |
|
| Child, Preschool |
|
| Chromosomes, Human, Pair 5 |
genetics |
| Diseases in Twins |
genetics |
| Eye |
pathology |
| Female |
pathology |
| Genetic Linkage |
pathology |
| Genotype |
pathology |
| Humans |
pathology |
| Lod Score |
pathology |
| Male |
pathology |
| Microsatellite Repeats |
pathology |
| Middle Aged |
pathology |
| Myopia |
genetics |
| Quantitative Trait Loci |
genetics |
| Quantitative Trait, Heritable |
genetics |
| Twins, Dizygotic |
genetics |
| Twins, Monozygotic |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
|
