|
|
| PMID |
|
|
| TITLE |
|
| Linkage analysis of a model quantitative trait in humans: finger ridge count shows significant multivariate linkage to 5q14.1. |
|
| ABSTRACT |
|
|
|
| The finger ridge count (a measure of pattern size) is one of the most heritable complex traits studied in humans and has been considered a model human polygenic trait in quantitative genetic analysis. Here, we report the results of the first genome-wide linkage scan for finger ridge count in a sample of 2,114 offspring from 922 nuclear families. Both univariate linkage to the absolute ridge count (a sum of all the ridge counts on all ten fingers), and multivariate linkage analyses of the counts on individual fingers, were conducted. The multivariate analyses yielded significant linkage to 5q14.1 (Logarithm of odds [LOD] = 3.34, pointwise-empirical p-value = 0.00025) that was predominantly driven by linkage to the ring, index, and middle fingers. The strongest univariate linkage was to 1q42.2 (LOD = 2.04, point-wise p-value = 0.002, genome-wide p-value = 0.29). In summary, the combination of univariate and multivariate results was more informative than simple univariate analyses alone. Patterns of quantitative trait loci factor loadings consistent with developmental fields were observed, and the simple pleiotropic model underlying the absolute ridge count was not sufficient to characterize the interrelationships between the ridge counts of individual fingers. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2007/05/08 |
| accepted |
2007/08/08 |
| pubmed |
2007/10/03 09:00 |
| medline |
2007/11/02 09:00 |
| entrez |
2007/10/03 09:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Medland SE |
|
Medland |
Sarah E |
SE |
|
Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia. smedland@vcu.edu |
| Loesch DZ |
|
Loesch |
Danuta Z |
DZ |
|
|
| Mdzewski B |
|
Mdzewski |
Bogdan |
B |
|
|
| Zhu G |
|
Zhu |
Gu |
G |
|
|
| Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 3 |
| ISSUE: 9 |
| TITLE: PLoS genetics |
| ISOABBREVIATION: PLoS Genet |
| YEAR: 2007 |
| MONTH: Sep |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1553-7404 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: PLoS Genet |
| COUNTRY: United States |
| ISSNLINKING: 1553-7390 |
| NLMUNIQUEID: 101239074 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Comparative Study |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
| CommentIn |
Forensic Sci Int Genet. 2018 Sep;36:e14-e16 |
29941291 |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| R01 AA007535 |
NIAAA NIH HHS |
United States |
| R01 AA014041 |
NIAAA NIH HHS |
United States |
| N01HG65403 |
NHGRI NIH HHS |
United States |
| AA013320 |
NIAAA NIH HHS |
United States |
| P50 AA011998 |
NIAAA NIH HHS |
United States |
| R01 AA007728 |
NIAAA NIH HHS |
United States |
| R01 AA013326 |
NIAAA NIH HHS |
United States |
| AA013326 |
NIAAA NIH HHS |
United States |
| AA07728 |
NIAAA NIH HHS |
United States |
| AA11998 |
NIAAA NIH HHS |
United States |
| AA014041 |
NIAAA NIH HHS |
United States |
| R01 AA010249 |
NIAAA NIH HHS |
United States |
| R37 AA007728 |
NIAAA NIH HHS |
United States |
| R01 AA013320 |
NIAAA NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Adult |
|
| Chi-Square Distribution |
|
| Chromosomes, Human, Pair 5 |
|
| Cohort Studies |
|
| Dermatoglyphics |
|
| Female |
|
| Fingers |
|
| Genetic Linkage |
|
| Genome, Human |
|
| Humans |
|
| Likelihood Functions |
|
| Lod Score |
|
| Male |
|
| Models, Genetic |
|
| Multivariate Analysis |
|
| Quantitative Trait Loci |
|
| Twin Studies as Topic |
methods |
| Twins, Dizygotic |
methods |
| Twins, Monozygotic |
methods |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
|
