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| PMID |
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| TITLE |
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| A longitudinal genetic study of uric acid and liver enzymes in adolescent twins. |
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| ABSTRACT |
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| Biochemical traits such as plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyltransferase (GGT) and uric acid are associated with obesity, and with risk of cardiovascular disease, metabolic syndrome and diabetes. Each is subject to genetic influences, but little is known about changes in genetic and environmental influences on these traits over time. We investigated the contribution of genetic and environmental influences to variation in these biochemical traits in adolescent twins and their nontwin siblings from 965 twin families. Twins were studied at ages 12, 14 and 16 years. Multivariate genetic models that included effects of age and sex were fitted to determine whether the same or different genetic or environmental factors influence each trait at different ages. Results showed that the genetic factors influencing AST, ALT, GGT and uric acid change over time during adolescence, and that the magnitude of these effects differs between males and females. The nonshared environment effects were generally time specific. There are developmental changes in genes affecting these traits during adolescence. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2007/10/02 09:00 |
| medline |
2008/03/15 09:00 |
| entrez |
2007/10/02 09:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Middelberg RP |
|
Middelberg |
Rita P S |
RP |
|
Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia. rita.middelberg@qimr.edu.au |
| Medland SE |
|
Medland |
Sarah E |
SE |
|
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| Martin NG |
|
Martin |
Nicholas G |
NG |
|
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| Whitfield JB |
|
Whitfield |
John B |
JB |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 10 |
| ISSUE: 5 |
| TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res Hum Genet |
| YEAR: 2007 |
| MONTH: Oct |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1832-4274 |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: Twin Res Hum Genet |
| COUNTRY: England |
| ISSNLINKING: 1832-4274 |
| NLMUNIQUEID: 101244624 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Twin Study |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
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| Age Factors |
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| Alanine Transaminase |
metabolism |
| Aspartate Aminotransferases |
metabolism |
| Environment |
metabolism |
| Female |
metabolism |
| Genetic Variation |
metabolism |
| Humans |
metabolism |
| Liver |
enzymology |
| Longitudinal Studies |
enzymology |
| Male |
enzymology |
| Multivariate Analysis |
enzymology |
| Twins, Dizygotic |
genetics |
| Twins, Monozygotic |
genetics |
| Uric Acid |
metabolism |
| gamma-Glutamyltransferase |
metabolism |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 268B43MJ25 |
Uric Acid |
| EC 2.3.2.2 |
gamma-Glutamyltransferase |
| EC 2.6.1.1 |
Aspartate Aminotransferases |
| EC 2.6.1.2 |
Alanine Transaminase |
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| OTHER ID's |
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