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| PMID |
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| TITLE |
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| Information-theoretic analysis of brain white matter fiber orientation distribution functions. |
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| ABSTRACT |
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| We propose a new information-theoretic metric, the symmetric Kullback-Leibler divergence (sKL-divergence), to measure the difference between two water diffusivity profiles in high angular resolution diffusion imaging (HARDI). Water diffusivity profiles are modeled as probability density functions on the unit sphere, and the sKL-divergence is computed from a spherical harmonic series, which greatly reduces computational complexity. Adjustment of the orientation of diffusivity functions is essential when the image is being warped, so we propose a fast algorithm to determine the principal direction of diffusivity functions using principal component analysis (PCA). We compare sKL-divergence with other inner-product based cost functions using synthetic samples and real HARDI data, and show that the sKL-divergence is highly sensitive in detecting small differences between two diffusivity profiles and therefore shows promise for applications in the nonlinear registration and multisubject statistical analysis of HARDI data. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2007/07/19 09:00 |
| medline |
2007/09/01 09:00 |
| entrez |
2007/07/19 09:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Chiang MC |
|
Chiang |
Ming-Chang |
MC |
|
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA. |
| Klunder AD |
|
Klunder |
Andrea D |
AD |
|
|
| McMahon K |
|
McMahon |
Katie |
K |
|
|
| de Zubicaray GI |
|
de Zubicaray |
Greig I |
GI |
|
|
| Wright MJ |
|
Wright |
Margaret J |
MJ |
|
|
| Toga AW |
|
Toga |
Arthur W |
AW |
|
|
| Thompson PM |
|
Thompson |
Paul M |
PM |
|
|
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| INVESTIGATORS |
|
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| JOURNAL |
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| VOLUME: 20 |
| ISSUE: |
| TITLE: Information processing in medical imaging : proceedings of the ... conference |
| ISOABBREVIATION: Inf Process Med Imaging |
| YEAR: 2007 |
| MONTH: |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1011-2499 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Inf Process Med Imaging |
| COUNTRY: Germany |
| ISSNLINKING: 1011-2499 |
| NLMUNIQUEID: 9216871 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Evaluation Studies |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
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| COMMENTS AND CORRECTIONS |
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| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
| Cites |
Inf Process Med Imaging. 2005;19:246-57 |
17354700 |
|
| Cites |
Inf Process Med Imaging. 2005;19:76-87 |
17354686 |
|
| Cites |
Med Image Anal. 2006 Oct;10(5):764-85 |
16899392 |
|
| Cites |
Med Image Comput Comput Assist Interv. 2005;8(Pt 1):156-63 |
16685841 |
|
| Cites |
IEEE Trans Med Imaging. 2005 Sep;24(9):1216-30 |
16156359 |
|
| Cites |
Magn Reson Med. 2005 Apr;53(4):866-76 |
15799039 |
|
| Cites |
Magn Reson Med. 1999 Sep;42(3):515-25 |
10467296 |
|
| Cites |
Magn Reson Imaging. 1998;16(1):87-90 |
9436952 |
|
| Cites |
Magn Reson Med. 2003 Jul;50(1):175-82 |
12815692 |
|
| Cites |
Magn Reson Med. 2002 Oct;48(4):577-82 |
12353272 |
|
| Cites |
Magn Reson Med. 2002 Aug;48(2):331-40 |
12210942 |
|
| Cites |
IEEE Trans Med Imaging. 2008 Apr;27(4):442-56 |
18390342 |
|
| Cites |
IEEE Trans Med Imaging. 2001 Nov;20(11):1131-9 |
11700739 |
|
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| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| AG016570 |
NIA NIH HHS |
United States |
| EB01651 |
NIBIB NIH HHS |
United States |
| HD050735 |
NICHD NIH HHS |
United States |
| NS049194 |
NINDS NIH HHS |
United States |
| R01 HD050735 |
NICHD NIH HHS |
United States |
| R01 HD050735-01A2 |
NICHD NIH HHS |
United States |
| RR019771 |
NCRR NIH HHS |
United States |
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| GENERAL NOTE |
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| KEYWORDS |
|
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| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Algorithms |
|
| Artificial Intelligence |
|
| Brain |
cytology |
| Computer Simulation |
cytology |
| Diffusion Magnetic Resonance Imaging |
methods |
| Image Enhancement |
methods |
| Image Interpretation, Computer-Assisted |
methods |
| Imaging, Three-Dimensional |
methods |
| Information Storage and Retrieval |
methods |
| Information Theory |
methods |
| Models, Neurological |
methods |
| Models, Statistical |
methods |
| Nerve Fibers, Myelinated |
ultrastructure |
| Pattern Recognition, Automated |
methods |
| Reproducibility of Results |
methods |
| Sensitivity and Specificity |
methods |
| Statistical Distributions |
methods |
|
| SUPPLEMENTARY MESH |
|
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| GENE SYMBOLS |
|
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| CHEMICALS |
|
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| OTHER ID's |
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| OTHERID |
SOURCE |
| NIHMS46111 |
NLM |
| PMC2383324 |
NLM |
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