|
|
| PMID |
|
|
| TITLE |
|
| Are there common genetic and environmental factors behind the endophenotypes associated with the metabolic syndrome? |
|
| ABSTRACT |
|
| AIMS/HYPOTHESIS |
NlmCategory: OBJECTIVE |
| The cluster of obesity, insulin resistance, dyslipidaemia and hypertension, called the metabolic syndrome, has been suggested as a risk factor for cardiovascular disease and type 2 diabetes. The aim of the present study was to evaluate whether there are common genetic and environmental factors influencing this cluster in a general population of twin pairs. |
| MATERIALS AND METHODS |
NlmCategory: METHODS |
| A multivariate genetic analysis was performed on nine endophenotypes associated with the metabolic syndrome from 625 adult twin pairs of the GEMINAKAR study of the Danish Twin Registry. |
| RESULTS |
NlmCategory: RESULTS |
| All endophenotypes showed moderate to high heritability (0.31-0.69) and small common environmental variance (0.05-0.21). In general, genetic and phenotypic correlations between the endophenotypes were strong only within sets of physiologically similar endophenotypes, but weak to moderate for other pairs of endophenotypes. However, moderate correlations between insulin resistance indices and either obesity-related endophenotypes or triacylglycerol levels indicated that some common genetic backgrounds are shared between those components. |
| CONCLUSIONS/INTERPRETATION |
NlmCategory: CONCLUSIONS |
| We demonstrated that, in a general population, the endophenotypes associated with the metabolic syndrome apparently do not share a substantial common genetic or familial environmental background. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2006/08/21 |
| accepted |
2007/06/05 |
| aheadofprint |
2007/07/12 |
| pubmed |
2007/07/13 09:00 |
| medline |
2008/01/08 09:00 |
| entrez |
2007/07/13 09:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Benyamin B |
|
Benyamin |
B |
B |
|
Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, Scotland, UK. |
| Sørensen TI |
|
Sørensen |
T I A |
TI |
|
|
| Schousboe K |
|
Schousboe |
K |
K |
|
|
| Fenger M |
|
Fenger |
M |
M |
|
|
| Visscher PM |
|
Visscher |
P M |
PM |
|
|
| Kyvik KO |
|
Kyvik |
K O |
KO |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 50 |
| ISSUE: 9 |
| TITLE: Diabetologia |
| ISOABBREVIATION: Diabetologia |
| YEAR: 2007 |
| MONTH: Sep |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0012-186X |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Diabetologia |
| COUNTRY: Germany |
| ISSNLINKING: 0012-186X |
| NLMUNIQUEID: 0006777 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Multicenter Study |
| Research Support, Non-U.S. Gov't |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
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| GENERAL NOTE |
|
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| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Aged |
|
| Blood Pressure |
|
| Body Mass Index |
|
| Environment |
|
| Female |
|
| Humans |
|
| Insulin Resistance |
physiology |
| Lipids |
blood |
| Lipoproteins |
blood |
| Male |
blood |
| Metabolic Syndrome X |
genetics |
| Middle Aged |
genetics |
| Obesity |
physiopathology |
| Phenotype |
physiopathology |
| Twins, Dizygotic |
physiopathology |
| Twins, Monozygotic |
physiopathology |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
Lipids |
| 0 |
Lipoproteins |
|
| OTHER ID's |
|
|
|
