Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
About GenEpi
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
17623712
TITLE
Twin study of the heritability of recognition thresholds for sour and salty taste.
ABSTRACT
Seventy-four pairs of monozygotic (identical) twins and 35 pairs of dizygotic (fraternal) twins provided recognition thresholds (modified Harris-Kalmus test) for the sourness of citric acid and the saltiness of sodium chloride during the Twins Days Festival in Twinsburg, OH. Variance components (ACE) models were applied to the data: total variation = additive genetic (A) + common environment (C) + nonshared environment (E). The best-fit model of variation in recognition thresholds for sourness included an additive genetic factor, accounting for 53% of the variance, but no common environment component. This level of heritability, on par with that of sensitivity to the bitter compounds 6-n-propylthiouracil and phenylthiocarbamide, strongly suggests that genetic factors play a larger role than shared environment in determining individual differences in recognition thresholds for sourness. In contrast, the best-fit model for saltiness recognition included a common environment component, accounting for 22% of the variance in thresholds, but no additive component. This result suggests that environment plays a larger role than genetics in determining individual differences in recognition thresholds for saltiness.
DATE PUBLISHED
2007 Oct
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2007/07/10
pubmed 2007/07/12 09:00
medline 2008/01/08 09:00
entrez 2007/07/12 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Wise PM Wise Paul M PM Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA. pwise@monell.org
Hansen JL Hansen Jonathan L JL
Reed DR Reed Danielle R DR
Breslin PA Breslin Paul A S PA
INVESTIGATORS
JOURNAL
VOLUME: 32
ISSUE: 8
TITLE: Chemical senses
ISOABBREVIATION: Chem. Senses
YEAR: 2007
MONTH: Oct
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0379-864X
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Chem Senses
COUNTRY: England
ISSNLINKING: 0379-864X
NLMUNIQUEID: 8217190
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Nature. 2001 Oct 11;413(6856):631-5 11675786
Cites Physiol Behav. 2007 Aug 15;91(5):620-31 17490693
Cites Physiol Behav. 2002 Nov;77(2-3):277-89 12419404
Cites Science. 2003 Feb 21;299(5610):1221-5 12595690
Cites Nat Rev Neurosci. 2004 Apr;5(4):263-78 15034552
Cites J Dent Res. 2004 Jun;83(6):448-53 15153450
Cites J Neurophysiol. 2004 Sep;92(3):1928-36 15140906
Cites Acta Genet Med Gemellol (Roma). 1967 Jul;16(3):229-43 6070729
Cites Gastroenterology. 1972 Jul;63(1):67-75 5055750
Cites Ann Hum Genet. 1975 Jan;38(3):321-6 1169903
Cites J Comp Physiol Psychol. 1975 May;89(3):279-84 1171128
Cites East Afr Med J. 1986 Apr;63(4):236-43 3732110
Cites Physiol Behav. 1987;40(2):221-7 3628532
Cites Hypertension. 1991 Jan;17(1 Suppl):I129-32 1986990
Cites Appetite. 1992 Feb;18(1):77-82 1562204
Cites Physiol Behav. 1993 Jul;54(1):179-84 8327600
Cites Am J Physiol. 1996 Apr;270(4 Pt 2):R704-12 8967397
Cites Appetite. 1995 Dec;25(3):231-40 8746963
Cites Appetite. 1996 Aug;27(1):65-77 8879420
Cites Behav Genet. 1996 Nov;26(6):563-73 8990535
Cites Nature. 1998 Oct 8;395(6702):555-6 9783580
Cites Physiol Behav. 1999 Aug;67(2):181-7 10477048
Cites Proc Soc Exp Biol Med. 1952 Jan;79(1):115-8 14892057
Cites Ann Eugen. 1949 Oct;15(1):24-31 15403125
Cites Chem Senses. 2005 Jan;30(1):89-103 15647467
Cites Curr Biol. 2005 Feb 22;15(4):322-7 15723792
Cites Twin Res Hum Genet. 2006 Apr;9(2):194-7 16611487
Cites Adv Otorhinolaryngol. 2006;63:152-90 16733339
Cites Chem Senses. 2006 Jun;31(5):403-13 16527870
Cites J Neurochem. 2006 Jul;98(1):68-77 16805797
Cites Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12569-74 16891422
Cites Nature. 2006 Aug 24;442(7105):934-8 16929298
Cites J Neurosci. 2002 Oct 1;22(19):8607-13 12351734
GRANTS
GRANTID AGENCY COUNTRY
R01 DC004698 NIDCD NIH HHS United States
R01 DC004698-03 NIDCD NIH HHS United States
R01DC002995 NIDCD NIH HHS United States
R01DC004698 NIDCD NIH HHS United States
R03 DC003509 NIDCD NIH HHS United States
R03ES013969 NIEHS NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Aged
Citric Acid chemistry
Environment chemistry
Female chemistry
Humans chemistry
Hydrogen-Ion Concentration chemistry
Male chemistry
Middle Aged chemistry
Models, Genetic chemistry
Perception chemistry
Phenylthiourea chemistry
Propylthiouracil chemistry
Salts chemistry
Taste chemistry
Taste Threshold chemistry
Twins, Dizygotic chemistry
Twins, Monozygotic chemistry
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Salts
2968PHW8QP Citric Acid
6F82C6Q54C Phenylthiourea
721M9407IY Propylthiouracil
OTHER ID's
OTHERID SOURCE
NIHMS27399 NLM
PMC2085364 NLM
Designed by: GenEpi IT
Maintained by: GenEpi IT
Feedback: webmaster
Copyright © 2007 QIMR
For more information Contact Us
epiit@qimr.edu.au
Last Modified: Oct 15 2007