Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
17606816
TITLE
Intergenerational transmission of childhood conduct problems: a Children of Twins Study.
ABSTRACT
CONTEXT NlmCategory: BACKGROUND
The familial nature of childhood conduct problems has been well documented, but few genetically informed studies have explicitly explored the processes through which parental conduct problems influence an offspring's behavior problems.
OBJECTIVE NlmCategory: OBJECTIVE
To delineate the genetic and environmental processes underlying the intergenerational transmission of childhood conduct problems.
DESIGN NlmCategory: METHODS
We used hierarchical linear models to analyze data from a Children of Twins Study, a quasiexperimental design, to explore the extent to which genetic factors common to both generations, unmeasured environmental factors that are shared by twins, or measured characteristics of both parents confound the intergenerational association.
SETTING NlmCategory: METHODS
Participants were recruited from the community and completed a semistructured diagnostic telephone interview.
PARTICIPANTS NlmCategory: METHODS
The research used a high-risk sample of twins, their spouses, and their young adult offspring (n = 2554) from 889 twin families in the Australian Twin Registry, but the analyses used sample weights to produce parameter estimates for the community-based volunteer sample of twins. Main Outcome Measure Number of conduct disorder symptoms.
RESULTS NlmCategory: RESULTS
The magnitude of the intergenerational transmission was significant for all offspring, though it was stronger for males (effect size [Cohen d] = 0.21; 95% confidence interval, 0.15-0.17) than females (d = 0.09; 95% confidence interval, 0.05-0.14). The use of the Children of Twins design and measured covariates indicated that the intergenerational transmission of conduct problems for male offspring was largely mediated by environmental variables specifically related to parental conduct disorder (d = 0.13; 95% confidence interval, 0.02-0.23). In contrast, the intergenerational transmission of conduct problems was not because of environmentally mediated causal processes for female offspring (d = - 0.09; 95% confidence interval, - 0.20 to 0.03); a common genetic liability accounted for the intergenerational relations.
CONCLUSIONS NlmCategory: CONCLUSIONS
The mechanisms underlying the intergenerational transmission of conduct problems depend on the sex of the offspring. The results are consistent with an environmentally mediated causal role of parental conduct problems on behavior problems in males. Common genetic risk, however, confounds the entire intergenerational transmission in female offspring.
DATE PUBLISHED
2007 Jul
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2007/07/04 09:00
medline 2007/07/21 09:00
entrez 2007/07/04 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
D'Onofrio BM D'Onofrio Brian M BM Department of Psychological and Brain Sciences, Indiana University, 1101 E 10th St, Bloomington, IN 47405, USA. bmdonofr@indiana.edu
Slutske WS Slutske Wendy S WS
Turkheimer E Turkheimer Eric E
Emery RE Emery Robert E RE
Harden KP Harden K Paige KP
Heath AC Heath Andrew C AC
Madden PA Madden Pamela A F PA
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 64
ISSUE: 7
TITLE: Archives of general psychiatry
ISOABBREVIATION: Arch. Gen. Psychiatry
YEAR: 2007
MONTH: Jul
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0003-990X
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Arch Gen Psychiatry
COUNTRY: United States
ISSNLINKING: 0003-990X
NLMUNIQUEID: 0372435
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
AA000264 NIAAA NIH HHS United States
AA07535 NIAAA NIH HHS United States
R01 HD056354 NICHD NIH HHS United States
R01 HD056354-01 NICHD NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Australia
Child
Child of Impaired Parents statistics & numerical data
Conduct Disorder genetics
Diseases in Twins genetics
Family Characteristics genetics
Family Relations genetics
Female genetics
Genetic Predisposition to Disease genetics
Humans genetics
Linear Models genetics
Male genetics
Mental Disorders genetics
Models, Genetic genetics
Parents psychology
Registries psychology
Research Design psychology
Risk Factors psychology
Sex Factors psychology
Social Environment psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS243211 NLM
PMC2965630 NLM
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Last Modified: Oct 15 2007